[Effects of intraventricular injection of anti-DSIP serum on sleep in rats].

Nakagaki K, Ebihara S, Usui S, Honda Y, Takahashi Y, Kato N

Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology1 Jun 1986Cited by 1 (Europe PMC)

PMID3776352PepBankPUB-03776352

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Delta sleep-inducing peptide (DSIP).

01AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome
In rats, injection of anti-DSIP serum into the lateral ventricle did not significantly change the latencies of slow wave sleep and paradoxical sleep compared with normal serum.
In plain wordsIn rats, blocking natural DSIP in the brain with antiserum did not change how fast slow wave or paradoxical sleep began, compared with normal serum.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeLatencies of slow wave sleep and paradoxical sleep
Study
ratn = 16
Comparator
Normal rabbit serum
Outcome group
Sleep · Sleep
Source sentences
Summary
ADS exerted no significant effect on the latencies of SWS and PS after injection in the light or dark period.
3 context sentences(design, population, supporting numbers)
Summary · context
A high titer of the rabbit antiserum specific for the C-terminal of DSIP was used.
Summary · context
Sixteen male SD rats were chronically implanted with electrodes for EEG and EMG and with a cannula into the lateral ventricle.
Summary · context
The rats were injected with anti-DSIP (ADS) or normal rabbit serum as a control at 10 microliter for 10 min immediately before the onset of the light or dark period, and thereafter the polygraphic recordings were performed for a 24-hr period.
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).
Report a problemFND-0377635201
02AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome
In rats, anti-DSIP serum did not affect the 10-minute distributions over the first 4 hours or the hourly distributions over 24 hours of slow wave sleep and paradoxical sleep.
In plain wordsIn rats, blocking natural DSIP with antiserum did not change slow wave or paradoxical sleep patterns over 24 hours, compared with normal serum.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeHourly and 10-minute distributions of slow wave sleep and paradoxical sleep
Study
ratn = 16
Comparator
Normal rabbit serum
Outcome group
Sleep · Sleep
Source sentences
Summary
For SWS and PS, neither the distributions measured each 10 min for the first 4 hr nor the hourly distributions for 24 hr were affected by ADS.
3 context sentences(design, population, supporting numbers)
Summary · context
A high titer of the rabbit antiserum specific for the C-terminal of DSIP was used.
Summary · context
Sixteen male SD rats were chronically implanted with electrodes for EEG and EMG and with a cannula into the lateral ventricle.
Summary · context
The rats were injected with anti-DSIP (ADS) or normal rabbit serum as a control at 10 microliter for 10 min immediately before the onset of the light or dark period, and thereafter the polygraphic recordings were performed for a 24-hr period.
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).
Report a problemFND-0377635202
03AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome
In rats, the first 12-hour amounts of slow wave sleep and paradoxical sleep were unaffected by anti-DSIP serum compared with normal serum.
In plain wordsIn rats, blocking natural DSIP with antiserum did not change slow wave or paradoxical sleep in the first 12 hours, compared with normal serum.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeAmounts of slow wave sleep and paradoxical sleep in the first 12 hours
Study
ratn = 16
Comparator
Normal rabbit serum
Outcome group
Sleep · Sleep
Source sentences
Summary
The first 12-hr amounts of SWS and PS were also unaffected by ADS.
3 context sentences(design, population, supporting numbers)
Summary · context
A high titer of the rabbit antiserum specific for the C-terminal of DSIP was used.
Summary · context
Sixteen male SD rats were chronically implanted with electrodes for EEG and EMG and with a cannula into the lateral ventricle.
Summary · context
The rats were injected with anti-DSIP (ADS) or normal rabbit serum as a control at 10 microliter for 10 min immediately before the onset of the light or dark period, and thereafter the polygraphic recordings were performed for a 24-hr period.
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).
Report a problemFND-0377635203

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 17:28 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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