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Study · Animal study (in vivo) · rat · 1986

4 results

Influence of delta-sleep inducing peptide on melatonin synthesis in the rat pineal gland.

Oaknin S, Troiani ME, Webb SM, Reiter RJ

Neuroscience letters1 Sept 1986Cited by 3 (Europe PMC)

PMID3774211 (opens in a new tab)DOI10.1016/0304-3940(86)90450-7 (opens in a new tab)PepBankPUB-03774211
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, DSIP at 15 nmol/kg significantly retarded the nighttime rise of pineal N-acetyltransferase activity at 3 h into the dark phase.

    In plain wordsIn rats, a DSIP dose delayed the night-time rise of a pineal enzyme.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseNighttime rise of pineal NAT activity at 3 h into dark
    Study

    ratn: not reported in source

    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    15 nmol/kgAs given in this study (rat).

    Source sentences

    Summary
    DSIP at a dose of 15 nmol/kg significantly retarded the nighttime rise of pineal NAT activity
    1 context sentence
    Summary · context
    Young adult rats received an injection of either saline or DSIP (either 15, 30 or 60 nmol/kg) at 20:00 h, immediately before lights out.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, DSIP at 15 nmol/kg significantly retarded the nighttime rise of pineal melatonin levels at 3 h into the dark phase.

    In plain wordsIn rats, a DSIP dose delayed the night-time rise of melatonin.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseNighttime rise of melatonin levels at 3 h into dark
    Study

    ratn: not reported in source

    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    15 nmol/kgAs given in this study (rat).

    Source sentences

    Summary
    DSIP at a dose of 15 nmol/kg significantly retarded the nighttime rise of pineal NAT activity and melatonin levels at 3 h into the dark phase.
    1 context sentence
    Summary · context
    Young adult rats received an injection of either saline or DSIP (either 15, 30 or 60 nmol/kg) at 20:00 h, immediately before lights out.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, pineal N-acetyltransferase activity at 01:00, 03:00 and 08:00 h was similar in all DSIP and saline groups.

    In plain wordsIn rats, the pineal enzyme activity at later time points did not differ between DSIP and saline groups.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changePineal NAT activity at later time points
    Study

    ratn: not reported in source

    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    15, 30 or 60 nmol/kgAs given in this study (rat).

    Source sentences

    Summary
    At the other two nocturnal time points (01:00 and 03:00 h) and the following morning (08:00 h) pineal NAT activity and melatonin levels were similar in all groups.
    1 context sentence
    Summary · context
    Young adult rats received an injection of either saline or DSIP (either 15, 30 or 60 nmol/kg) at 20:00 h, immediately before lights out.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats, pineal melatonin levels at 01:00, 03:00 and 08:00 h were similar in all DSIP and saline groups.

    In plain wordsIn rats, melatonin levels at later time points did not differ between DSIP and saline groups.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changePineal melatonin levels at later time points
    Study

    ratn: not reported in source

    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    15, 30 or 60 nmol/kgAs given in this study (rat).

    Source sentences

    Summary
    At the other two nocturnal time points (01:00 and 03:00 h) and the following morning (08:00 h) pineal NAT activity and melatonin levels were similar in all groups.
    1 context sentence
    Summary · context
    Young adult rats received an injection of either saline or DSIP (either 15, 30 or 60 nmol/kg) at 20:00 h, immediately before lights out.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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