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Study · Not a test of the peptide alone · 1986

5 results

Entry of DSIP peptides into dog CSF: role of physicochemical and pharmacokinetic parameters.

Banks WA, Kastin AJ, Coy DH, Angulo E

Brain research bulletin1 Aug 1986Cited by 26 (Europe PMC)

PMID3768731 (opens in a new tab)DOI10.1016/0361-9230(86)90111-5 (opens in a new tab)PepBankPUB-03768731
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Delta sleep-inducing peptide (DSIP).

  1. 01AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Pharmacokinetics

    In dogs given DSIP or analogs intravenously, the increase in CSF peptide concentration correlated significantly with the increase in plasma concentration.

    In plain wordsIn dogs, more DSIP-like peptide in spinal fluid went with more peptide in blood.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableCSF peptide increase vs plasma concentration increase
    Study

    dogn: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    The increase in peptide concentration in the CSF correlated significantly with the increase in plasma concentration,
    1 context sentence
    Summary · context
    Delta sleep-inducing peptide (DSIP) or one of four DSIP analogs (desTrp-DSIP, D-Ala3-DSIP, D-Ala4-DSIP, D-Ala4-DSIP-NH2), was injected IV into dogs.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

  2. 02AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Pharmacokinetics

    In dogs given DSIP or analogs intravenously, the increase in CSF peptide concentration correlated significantly with plasma half-life.

    In plain wordsIn dogs, the rise of peptide in spinal fluid was linked to the peptide half-life in blood.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableCSF peptide increase vs plasma half-life
    Study

    dogn: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    The increase in peptide concentration in the CSF correlated significantly with the increase in plasma concentration, with plasma half-life,
    1 context sentence
    Summary · context
    Delta sleep-inducing peptide (DSIP) or one of four DSIP analogs (desTrp-DSIP, D-Ala3-DSIP, D-Ala4-DSIP, D-Ala4-DSIP-NH2), was injected IV into dogs.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

  3. 03AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Pharmacokinetics

    In dogs given DSIP or analogs intravenously, the increase in CSF peptide concentration correlated significantly with peptide lipophilicity.

    In plain wordsIn dogs, the rise of peptide in spinal fluid was linked to the fat solubility of the peptide.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableCSF peptide increase vs lipophilicity
    Study

    dogn: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    The increase in peptide concentration in the CSF correlated significantly with the increase in plasma concentration, with plasma half-life, and with peptide lipophilicity,
    1 context sentence
    Summary · context
    Delta sleep-inducing peptide (DSIP) or one of four DSIP analogs (desTrp-DSIP, D-Ala3-DSIP, D-Ala4-DSIP, D-Ala4-DSIP-NH2), was injected IV into dogs.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

  4. 04AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Pharmacokinetics

    In dogs given DSIP or analogs intravenously, the increase in CSF peptide concentration did not correlate with plasma protein binding or molecular weight.

    In plain wordsIn dogs, peptide levels in spinal fluid did not go with plasma protein binding or molecular weight.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeCSF peptide increase vs plasma protein binding and molecular weight
    Study

    dogn: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    but not with the degree of plasma protein binding or with molecular weight.
    1 context sentence
    Summary · context
    Delta sleep-inducing peptide (DSIP) or one of four DSIP analogs (desTrp-DSIP, D-Ala3-DSIP, D-Ala4-DSIP, D-Ala4-DSIP-NH2), was injected IV into dogs.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

  5. 05AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Pharmacokinetics

    In dogs given DSIP or analogs intravenously, a combined parameter of the three independently correlating factors correlated better with CSF peptide increase (r = 0.813).

    In plain wordsIn dogs, combining blood level, half-life and fat solubility predicted peptide levels in spinal fluid better than any one alone.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableCSF peptide increase vs combined plasma level, half-life and lipophilicity
    Study

    dogn: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology

    Measurements

    correlation coefficient r
    0.813
    combined parameter

    Source sentences

    Summary
    An even better correlation occurred when the three factors that correlated independently were combined into a single parameter (r = 0.813, p less than 0.00005).
    1 context sentence
    Summary · context
    Delta sleep-inducing peptide (DSIP) or one of four DSIP analogs (desTrp-DSIP, D-Ala3-DSIP, D-Ala4-DSIP, D-Ala4-DSIP-NH2), was injected IV into dogs.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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