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Study · Animal study (in vivo) · rat · 1986

1 result

Structure-activity relationship in the effects of delta-sleep-inducing peptide (DSIP) on rat sleep.

Obál F Jr, Kovalzon VM, Kalikhevich VN, Török A, Alföldi P, Sáry G, Hajós M, Penke B

Pharmacology, biochemistry, and behavior1 Apr 1986Cited by 9 (Europe PMC)

PMID3754970 (opens in a new tab)DOI10.1016/0091-3057(86)90432-6 (opens in a new tab)PepBankPUB-03754970
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, intracerebroventricular DSIP did not increase sleep compared with baseline records after artificial CSF injection.

    In plain wordsIn rats, DSIP injected into the brain fluid did not increase sleep compared with baseline.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeSleep after DSIP injection
    Study

    ratn: not reported in source

    Comparator
    Artificial CSF baseline
    Outcome group
    Sleep · Sleep
    Studied dose
    7 nmol/kg · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    DSIP did not increase sleep, whereas both [D-Trp1]-DSIP and [D-Tyr1]-DSIP promoted sleep in the first part of the night.
    1 context sentence
    Summary · context
    DSIP and its analogues, [D-Trp1]-DSIP, [D-Tyr1]-DSIP, and [D-Trp1]-DSIP1-6, were injected ICV (7 nmol/kg) into rats at dark onset, and the sleep-wake activity was recorded during the 12-hr dark period and the subsequent 12-hr light period.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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