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Study · Animal study (in vivo) · rabbit · 1986

3 results

[Effect of the delta-sleep peptide on parasympathetic regulation of the cardiac rhythm].

Zviagintseva MA, Kosharskaia IL, Ul'ianinskiĭ LS

Biulleten' eksperimental'noi biologii i meditsiny1 Apr 1986

PMID3754472 (opens in a new tab)PepBankPUB-03754472
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In voluntarily behaving rabbits, intravenous delta-sleep peptide reduced heart rate by an average of 16%.

    In plain wordsIn rabbits, delta-sleep peptide given into a vein slowed the heart rate by an average of 16%.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseHeart rate
    Study

    rabbitn: not reported in source

    Outcome group
    Heart function · Cardiovascular
    Studied dose
    60 nM/kg · intravenousAs given in this study (rabbit).

    Measurements

    Heart rate reduction
    16%
    rabbits

    Source sentences

    Summary
    intravenous administration of this peptide to voluntary-behaving animals results in heart rate reduction by an average of 16%
    1 context sentence
    Summary · context
    Effect of delta-sleep peptide (60 nM/kg) on the parasympathetic regulation of cardiac activity has been studied in the experiments on rabbits.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rabbits, the heart rate reduction caused by delta-sleep peptide could be eliminated by atropine.

    In plain wordsIn rabbits, the slower heart rate caused by delta-sleep peptide could be removed by atropine.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeHeart rate reduction blocked by atropine
    Study

    rabbitn: not reported in source

    Outcome group
    Heart function · Cardiovascular
    Studied dose
    60 nM/kg · intravenousAs given in this study (rabbit).

    Source sentences

    Summary
    heart rate reduction by an average of 16%, that can be eliminated by atropine.
    1 context sentence
    Summary · context
    Effect of delta-sleep peptide (60 nM/kg) on the parasympathetic regulation of cardiac activity has been studied in the experiments on rabbits.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rabbits, delta-sleep peptide intensified the negative chronotropic effect of a directly irritated vagus nerve.

    In plain wordsIn rabbits, delta-sleep peptide strengthened the heart-slowing effect of direct vagus nerve irritation.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseNegative chronotropic effect of directly irritated vagus nerve
    Study

    rabbitn: not reported in source

    Outcome group
    Heart function · Cardiovascular
    Studied dose
    60 nM/kgAs given in this study (rabbit).

    Source sentences

    Summary
    Delta-sleep peptide has been demonstrated to intensify negative chronotropic effect in the case of directly irritated wandering nerve.
    1 context sentence
    Summary · context
    Effect of delta-sleep peptide (60 nM/kg) on the parasympathetic regulation of cardiac activity has been studied in the experiments on rabbits.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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