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Study · Animal study (in vivo) · rat · 1986

10 results

Peripheral versus central components of the effects of dermorphin on intestinal motility in the fed rat.

Ferré JP, Du C, Soldani G, Ruckebusch Y

Regulatory peptides1 Jan 1986Cited by 8 (Europe PMC)

PMID3754059 (opens in a new tab)DOI10.1016/0167-0115(86)90218-1 (opens in a new tab)PepBankPUB-03754059
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In fed rats, subcutaneous dermorphin restored the duodenal fasting pattern and inhibited the fed pattern by about 40%.

    In plain wordsIn fed rats, subcutaneous dermorphin restored fasting-like duodenal activity and reduced the fed pattern by about 40%.

    Peptide
    Dermorphin
    Outcome
    DecreaseDuodenal fed activity pattern after subcutaneous injection
    Study

    ratn: not reported in source

    fed rats with chronically implanted intestinal electrodes
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    0.5 nM per rat · subcutaneous · 120 minAs given in this study (rat).

    Measurements

    Fed pattern inhibition
    ≈ 40%
    subcutaneous dermorphin

    Source sentences

    Summary
    DER s.c. restored the 'fasting' pattern of duodenal activity, i.e., the migrating myoelectric complex (MMC), corresponding to an inhibition by about 40% of the fed pattern for 120 min at a dose as small as 0.5 nM per rat.
    1 context sentence
    Summary · context
    The effects of subcutaneous (s.c.), intraperitoneal (i.p.), intrathecal (i.t.) and intracerebroventricular (i.c.v.) injection of dermorphin (DER) on intestinal myoelectrical activity were examined in fed rats with chronically implanted electrodes on the small and large bowel.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In fed rats, intraperitoneal dermorphin inhibited the fed intestinal activity pattern by about 65%.

    In plain wordsIn fed rats, intraperitoneal dermorphin reduced the fed intestinal activity pattern by about 65%.

    Peptide
    Dermorphin
    Outcome
    DecreaseFed activity pattern after intraperitoneal injection
    Study

    ratn: not reported in source

    fed rats with chronically implanted intestinal electrodes
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    Dose not stated · intraperitoneal · 120 minAs given in this study (rat).

    Measurements

    Fed pattern inhibition
    ≈ 65%
    intraperitoneal dermorphin

    Source sentences

    Summary
    DER i.p. strongly inhibited (about 65%) the fed pattern for 120 min.
    1 context sentence
    Summary · context
    The effects of subcutaneous (s.c.), intraperitoneal (i.p.), intrathecal (i.t.) and intracerebroventricular (i.c.v.) injection of dermorphin (DER) on intestinal myoelectrical activity were examined in fed rats with chronically implanted electrodes on the small and large bowel.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In fed rats, intrathecal dermorphin produced a fasting intestinal activity pattern lasting 80 min.

    In plain wordsIn fed rats, intrathecal dermorphin produced fasting-like intestinal activity for 80 min.

    Peptide
    Dermorphin
    Outcome
    Not applicableFasting activity pattern after intrathecal injection
    Study

    ratn: not reported in source

    fed rats with chronically implanted intestinal electrodes
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    0.5 nM · intrathecal · 80 minAs given in this study (rat).

    Source sentences

    Summary
    A fasting pattern lasting 80 min, or a marked inhibition lasting 150 min were recorded after 0.5 nM DER i.t. or i.c.v., respectively.
    1 context sentence
    Summary · context
    The effects of subcutaneous (s.c.), intraperitoneal (i.p.), intrathecal (i.t.) and intracerebroventricular (i.c.v.) injection of dermorphin (DER) on intestinal myoelectrical activity were examined in fed rats with chronically implanted electrodes on the small and large bowel.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In fed rats, intracerebroventricular dermorphin produced marked intestinal activity inhibition lasting 150 min.

    In plain wordsIn fed rats, intracerebroventricular dermorphin reduced intestinal activity for 150 min.

    Peptide
    Dermorphin
    Outcome
    DecreaseIntestinal activity inhibition after intracerebroventricular injection
    Study

    ratn: not reported in source

    fed rats with chronically implanted intestinal electrodes
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    0.5 nM · intracerebroventricular · 150 minAs given in this study (rat).

    Source sentences

    Summary
    A fasting pattern lasting 80 min, or a marked inhibition lasting 150 min were recorded after 0.5 nM DER i.t. or i.c.v., respectively.
    1 context sentence
    Summary · context
    The effects of subcutaneous (s.c.), intraperitoneal (i.p.), intrathecal (i.t.) and intracerebroventricular (i.c.v.) injection of dermorphin (DER) on intestinal myoelectrical activity were examined in fed rats with chronically implanted electrodes on the small and large bowel.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In fed rats, dermorphin inhibited the colonic activity pattern through every tested route, with route-dependent duration.

    In plain wordsIn fed rats, dermorphin reduced colonic activity through every tested route, with different durations.

    Peptide
    Dermorphin
    Outcome
    DecreaseColonic activity pattern
    Study

    ratn: not reported in source

    fed rats with chronically implanted intestinal electrodes
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    On the contrary, the colonic pattern of activity was inhibited by DER whatever the route used, although the duration of inhibition was different from each other.
    1 context sentence
    Summary · context
    The effects of subcutaneous (s.c.), intraperitoneal (i.p.), intrathecal (i.t.) and intracerebroventricular (i.c.v.) injection of dermorphin (DER) on intestinal myoelectrical activity were examined in fed rats with chronically implanted electrodes on the small and large bowel.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In fed rats, dermorphin affected small intestinal activity more efficiently through intracerebroventricular than intrathecal administration at similar doses.

    In plain wordsIn fed rats, dermorphin affected small intestinal activity more efficiently through intracerebroventricular than intrathecal administration at similar doses.

    Peptide
    Dermorphin
    Outcome
    IncreaseSmall intestinal activity effect by central route
    Study

    ratn: not reported in source

    fed rats with chronically implanted intestinal electrodes
    Comparator
    intrathecal dermorphin at similar doses
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    For both the small and large intestine, similar doses of DER were more efficient by i.c.v. than by i.t. routes, and by i.p. than by s.c. routes.
    1 context sentence
    Summary · context
    The effects of subcutaneous (s.c.), intraperitoneal (i.p.), intrathecal (i.t.) and intracerebroventricular (i.c.v.) injection of dermorphin (DER) on intestinal myoelectrical activity were examined in fed rats with chronically implanted electrodes on the small and large bowel.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In fed rats, dermorphin affected large intestinal activity more efficiently through intracerebroventricular than intrathecal administration at similar doses.

    In plain wordsIn fed rats, dermorphin affected large intestinal activity more efficiently through intracerebroventricular than intrathecal administration at similar doses.

    Peptide
    Dermorphin
    Outcome
    IncreaseLarge intestinal activity effect by central route
    Study

    ratn: not reported in source

    fed rats with chronically implanted intestinal electrodes
    Comparator
    intrathecal dermorphin at similar doses
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    For both the small and large intestine, similar doses of DER were more efficient by i.c.v. than by i.t. routes, and by i.p. than by s.c. routes.
    1 context sentence
    Summary · context
    The effects of subcutaneous (s.c.), intraperitoneal (i.p.), intrathecal (i.t.) and intracerebroventricular (i.c.v.) injection of dermorphin (DER) on intestinal myoelectrical activity were examined in fed rats with chronically implanted electrodes on the small and large bowel.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In fed rats, dermorphin affected small intestinal activity more efficiently through intraperitoneal than subcutaneous administration at similar doses.

    In plain wordsIn fed rats, dermorphin affected small intestinal activity more efficiently through intraperitoneal than subcutaneous administration at similar doses.

    Peptide
    Dermorphin
    Outcome
    IncreaseSmall intestinal activity effect by peripheral route
    Study

    ratn: not reported in source

    fed rats with chronically implanted intestinal electrodes
    Comparator
    subcutaneous dermorphin at similar doses
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    For both the small and large intestine, similar doses of DER were more efficient by i.c.v. than by i.t. routes, and by i.p. than by s.c. routes.
    1 context sentence
    Summary · context
    The effects of subcutaneous (s.c.), intraperitoneal (i.p.), intrathecal (i.t.) and intracerebroventricular (i.c.v.) injection of dermorphin (DER) on intestinal myoelectrical activity were examined in fed rats with chronically implanted electrodes on the small and large bowel.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In fed rats, dermorphin affected large intestinal activity more efficiently through intraperitoneal than subcutaneous administration at similar doses.

    In plain wordsIn fed rats, dermorphin affected large intestinal activity more efficiently through intraperitoneal than subcutaneous administration at similar doses.

    Peptide
    Dermorphin
    Outcome
    IncreaseLarge intestinal activity effect by peripheral route
    Study

    ratn: not reported in source

    fed rats with chronically implanted intestinal electrodes
    Comparator
    subcutaneous dermorphin at similar doses
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    For both the small and large intestine, similar doses of DER were more efficient by i.c.v. than by i.t. routes, and by i.p. than by s.c. routes.
    1 context sentence
    Summary · context
    The effects of subcutaneous (s.c.), intraperitoneal (i.p.), intrathecal (i.t.) and intracerebroventricular (i.c.v.) injection of dermorphin (DER) on intestinal myoelectrical activity were examined in fed rats with chronically implanted electrodes on the small and large bowel.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In fed rats, intracerebroventricular dermorphin produced a more intense immediate colonic effect than intrathecal dermorphin.

    In plain wordsIn fed rats, intracerebroventricular dermorphin affected the colon more intensely than intrathecal dermorphin.

    Peptide
    Dermorphin
    Outcome
    IncreaseImmediate colonic effect by central route
    Study

    ratn: not reported in source

    fed rats with chronically implanted intestinal electrodes
    Comparator
    intrathecal dermorphin
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    0.1 nM · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    The supraspinal component of the immediate effects of i.c.v. DER (0.1 nM) were demonstrated by a preferential effect on the colon that was even more intense than after i.t. DER.
    1 context sentence
    Summary · context
    The effects of subcutaneous (s.c.), intraperitoneal (i.p.), intrathecal (i.t.) and intracerebroventricular (i.c.v.) injection of dermorphin (DER) on intestinal myoelectrical activity were examined in fed rats with chronically implanted electrodes on the small and large bowel.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

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