Feedback regulation of the secretion of a thymic hormone (thymulin) by human thymic epithelial cells in culture.

Cohen S, Berrih S, Dardenne M, Bach JF

Thymus1 Jan 1986Cited by 24 (Europe PMC)

PMID3750381PepBankPUB-03750381

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

1 result from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In human thymic epithelial cultures, added synthetic thymulin significantly reduced the increase in thymulin-containing cells.
In plain wordsIn cells from human thymus tissue, added synthetic thymulin reduced the increase in cells containing thymulin.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseIncrease in thymulin-containing cells
Study
humann: not reported in source
Primary human thymic epithelial cultures
Outcome group
Receptor activity and mechanism · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Addition of synthetic thymulin to the culture medium reduced significantly the increase of thymulin-containing cells.
1 context sentence(design, population, supporting numbers)
Summary · context
The production of the thymic hormone, thymulin (FTS), was studied in primary cultures of human thymic epithelium by immunofluorescence using monoclonal anti-thymulin antibodies.
Report a problemFND-0375038103

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

02LabEndogenous levelIn vitro (cells)Activity measurement
In human thymic epithelial cultures, the number of cells containing endogenous thymulin increased gradually during culture.
In plain wordsIn cells from human thymus tissue, the number containing natural thymulin increased during culture.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseThymulin-containing cells over culture time
Study
humann: not reported in source
Primary human thymic epithelial cultures
Outcome group
Receptor activity and mechanism · Immune and inflammation
Source sentences
Summary
The number of thymulin-containing cells and the thymulin level in the culture supernatant increased gradually during the culture.
1 context sentence(design, population, supporting numbers)
Summary · context
The production of the thymic hormone, thymulin (FTS), was studied in primary cultures of human thymic epithelium by immunofluorescence using monoclonal anti-thymulin antibodies.
This result measures the body's own Thymulin (serum thymic factor). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0375038101
03LabEndogenous levelIn vitro (cells)Activity measurement
In human thymic epithelial cultures, endogenous thymulin levels in the supernatant increased gradually during culture.
In plain wordsIn lab tests, natural thymulin levels increased in fluid surrounding human thymic epithelial cells during culture.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseSupernatant thymulin level over culture time
Study
humann: not reported in source
Primary human thymic epithelial cultures
Outcome group
Receptor activity and mechanism · Immune and inflammation
Source sentences
Summary
The number of thymulin-containing cells and the thymulin level in the culture supernatant increased gradually during the culture.
1 context sentence(design, population, supporting numbers)
Summary · context
The production of the thymic hormone, thymulin (FTS), was studied in primary cultures of human thymic epithelium by immunofluorescence using monoclonal anti-thymulin antibodies.
This result measures the body's own Thymulin (serum thymic factor). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0375038102
04LabEndogenous levelIn vitro (cells)Mechanism
In human thymic epithelial cultures, anti-thymulin antibody exacerbated the spontaneous increase in cells containing endogenous thymulin.
In plain wordsIn cells from human thymus tissue, anti-thymulin antibody increased the spontaneous rise in cells containing natural thymulin.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseThymulin-containing cells after antibody treatment
Study
humann: not reported in source
Primary human thymic epithelial cultures
Outcome group
Receptor activity and mechanism · Immune and inflammation
Source sentences
Summary
Conversely, addition of monoclonal anti-thymulin antibody from the beginning of the culture exacerbated the spontaneous increase of thymulin-containing cells and abrogated the effects of thymulin.
1 context sentence(design, population, supporting numbers)
Summary · context
The production of the thymic hormone, thymulin (FTS), was studied in primary cultures of human thymic epithelium by immunofluorescence using monoclonal anti-thymulin antibodies.
This result measures the body's own Thymulin (serum thymic factor). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0375038104

Studies that did not test the peptide alone1

In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymulin (serum thymic factor).

05LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cells)Mechanism
In human thymic epithelial cultures, anti-thymulin antibody abrogated the effects of added thymulin.
In plain wordsIn cells from human thymus tissue, anti-thymulin antibody blocked the effects of added thymulin.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseAntibody blockade of thymulin effects
Study
humann: not reported in source
Primary human thymic epithelial cultures
Outcome group
Receptor activity and mechanism · Immune and inflammation
Source sentences
Summary
Conversely, addition of monoclonal anti-thymulin antibody from the beginning of the culture exacerbated the spontaneous increase of thymulin-containing cells and abrogated the effects of thymulin.
2 context sentences(design, population, supporting numbers)
Summary · context
Addition of synthetic thymulin to the culture medium reduced significantly the increase of thymulin-containing cells.
Summary · context
The production of the thymic hormone, thymulin (FTS), was studied in primary cultures of human thymic epithelium by immunofluorescence using monoclonal anti-thymulin antibodies.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-0375038105

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 2
21 Oct 2026, 13:55 UTC
Study data updated · source update from Europe PMC
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC