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Study · Not a test of the peptide alone · 1986

4 results

[Active analog of the inactive "sleep peptide"].

Koval'zon VM, Kalikhevich VN, Churkina SI

Biulleten' eksperimental'noi biologii i meditsiny1 Jun 1986

PMID3730559 (opens in a new tab)DOI10.1007/bf00839580 (opens in a new tab)PepBankPUB-03730559
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Delta sleep-inducing peptide (DSIP).

  1. 01AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome

    In rabbits, intracerebrovascular administration of the DSIP analogue (D-TrpI)DSIP at 0.7, 7 and 70 micrograms/kg increased slow wave sleep by 40% versus saline.

    In plain wordsIn rabbits, a DSIP analogue given into the brain increased slow wave sleep more than saline did. This is not DSIP itself.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseSlow wave sleep after intracerebroventricular analogue
    Study

    rabbitn: not reported in source

    Comparator
    Physiologic saline
    Outcome group
    Sleep · Sleep

    Measurements

    Slow wave sleep increase
    40%
    (D-TrpI)DSIP at 0.7, 7 and 70 micrograms/kg

    Source sentences

    Summary
    Its intracerebrovascular administration in doses of 0.7, 7 and 70 micrograms/kg body weight induced a significant increase in slow wave sleep (by 40%; p less than 0.01, U-test) and rectal temperature elevation (by 0.9 degrees C; p less than 0.01) within the following 3 day-light hours, as compared t…
    1 context sentence
    Summary · context
    Its analogue (D-TrpI)DSIP was more stable against aminopeptidases.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

  2. 02AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Other

    In rabbits, intracerebrovascular administration of the DSIP analogue (D-TrpI)DSIP at 0.7, 7 and 70 micrograms/kg raised rectal temperature by 0.9 degrees C versus saline.

    In plain wordsIn rabbits, a DSIP analogue given into the brain raised body temperature more than saline did. This is not DSIP itself.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseRectal temperature after intracerebroventricular analogue
    Study

    rabbitn: not reported in source

    Comparator
    Physiologic saline
    Outcome group
    Body temperature · Whole body

    Measurements

    Rectal temperature elevation
    0.9 degrees C
    (D-TrpI)DSIP at 0.7, 7 and 70 micrograms/kg

    Source sentences

    Summary
    Its intracerebrovascular administration in doses of 0.7, 7 and 70 micrograms/kg body weight induced a significant increase in slow wave sleep (by 40%; p less than 0.01, U-test) and rectal temperature elevation (by 0.9 degrees C; p less than 0.01) within the following 3 day-light hours, as compared t…
    1 context sentence
    Summary · context
    Its analogue (D-TrpI)DSIP was more stable against aminopeptidases.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

  3. 03AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome

    In rabbits, intravenous injections of the DSIP analogue increased slow wave sleep by 25% in a narrow dose range of 30-70 micrograms/kg.

    In plain wordsIn rabbits, a DSIP analogue given into a vein increased slow wave sleep within a narrow dose range. This is not DSIP itself.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseSlow wave sleep after intravenous analogue
    Study

    rabbitn: not reported in source

    Outcome group
    Sleep · Sleep

    Measurements

    Slow wave sleep increase
    25%
    intravenous (D-TrpI)DSIP, 30-70 micrograms/kg

    Source sentences

    Summary
    Intravenous injections of the DSIP analogue increased slow wave sleep by 25% in a narrow dose range (30-70 micrograms/kg).
    1 context sentence
    Summary · context
    Its analogue (D-TrpI)DSIP was more stable against aminopeptidases.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

  4. 04LabNot a test of Delta sleep-inducing peptide (DSIP) aloneIn vitro (cell-free)Other

    The DSIP analogue (D-TrpI)DSIP was more stable against aminopeptidases than DSIP.

    In plain wordsIn lab tests, the DSIP analogue broke down less than DSIP when exposed to aminopeptidase enzymes.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableStability of the analogue against aminopeptidases
    Study

    n: not reported in source

    Comparator
    DSIP
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    Its analogue (D-TrpI)DSIP was more stable against aminopeptidases.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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