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Study · Measured the body's own peptide · 1986

4 results

A radioimmunoassay for thymosin alpha-1.

Incefy GS, Ishimura K, Wang JG, Unson CG, Erickson BW

Journal of immunological methods1 May 1986Cited by 5 (Europe PMC)

PMID3701071 (opens in a new tab)DOI10.1016/0022-1759(86)90026-8 (opens in a new tab)PepBankPUB-03701071
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelEx vivo tissueOther

    In 6 human thymus homogenates, alpha-1-(1-28)-like immunoreactivity ranged from 0.5 to 4.5 ng/mg of protein.

    In plain wordsIn human thymus tissue samples, the body's own thymosin alpha‑1 was measured at 0.5 to 4.5 ng per mg of protein.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableAlpha-1-(1-28)-like immunoreactivity in human thymus
    Study

    humann = 6

    Outcome group
    Immune response · Immune and inflammation

    Measurements

    alpha-1-(1-28)-like immunoreactivity
    0.5 to 4.5 ng/mg protein
    human thymus homogenates

    Source sentences

    Summary
    In addition, alpha-1-(1-28)-like immunoreactivity was quantitated in 6 human thymus homogenates and ranged from 0.5 to 4.5 ng/mg of protein.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  2. 02LabEndogenous levelIn vitro (cells)Other

    The assay antiserum detected natural alpha-1 cross-reacting material in the cytoplasm of cultured human thymic epithelial cells by indirect immunofluorescence.

    In plain wordsIn cultured human thymus cells, the body's own thymosin alpha‑1-like material was detected inside the cells.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableNatural alpha-1 cross-reacting material in thymic epithelial cells
    Study

    humann: not reported in source

    cultured human thymic epithelial cells
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    It could also detect natural alpha-1 cross-reacting material in the cytoplasm of cultured human thymic epithelial cells as measured by indirect immunofluorescence.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone2

In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin alpha-1.

  1. 03LabNot a test of Thymosin alpha-1 aloneIn vitro (cell-free)Other

    A new radioimmunoassay could detect as little as 9 pg of alpha-1-(15-28) equivalents in a 50 microliter sample.

    In plain wordsA new lab test can detect very small amounts of thymosin alpha‑1 fragments in a sample.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableRadioimmunoassay detection limit
    Study

    n: not reported in source

    radioimmunoassay
    Outcome group
    Pharmacokinetics · Pharmacology

    Measurements

    detection limit
    9 pg
    alpha-1-(15-28) equivalents in 50 microliter sample

    Source sentences

    Summary
    In the RIA, as little as 9 pg of alpha-1-(15-28) equivalents in a 50 microliter sample could be detected.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  2. 04LabNot a test of Thymosin alpha-1 aloneIn vitro (cell-free)Other

    The anti-alpha-1-(15-28) antiserum recognized alpha-1-(15-28), its tyrosyl analogue and alpha-1-(1-28), but not other thymic hormones, thymopoietin segment 32-36 or unrelated peptides.

    In plain wordsIn lab tests, the antibody used in the new assay bound thymosin alpha‑1 but not other thymic hormones or unrelated peptides.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableAntiserum specificity
    Study

    n: not reported in source

    radioimmunoassay
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    An anti-alpha-1-(15-28) antiserum was raised in a rabbit and was shown to recognize alpha-1-(15-28) or its tyrosyl analogue, and the peptide, alpha-1-(1-28). But it did not recognize other thymic hormones or the biologically active segment 32-36 of thymopoietin, or structurally unrelated peptides.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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