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Study · Non-randomized trial · n = 1 · 1986

3 results

Dermorphin inhibits spinal nociceptive flexion reflex in humans.

Sandrini G, Degli Uberti EC, Salvadori S, Margutti A, Trasforini G, Tomatis R, Nappi G, Pansini R

Brain research1 Apr 1986Cited by 23 (Europe PMC)

PMID3697765 (opens in a new tab)DOI10.1016/0006-8993(86)90376-8 (opens in a new tab)PepBankPUB-03697765
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In healthy volunteers, dermorphin markedly increased the nociceptive flexion reflex threshold with a long-lasting effect.

    In plain wordsIn healthy volunteers, dermorphin raised the threshold for a pain-related reflex, with a lasting effect.

    Peptide
    Dermorphin
    Outcome
    IncreaseNociceptive flexion reflex threshold
    Study

    n: not reported in source

    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    0.16 mg/kg · intravenous infusionAs given in this study (human).

    Source sentences

    Summary
    Our study shows that i.v. infusion of 0.16 mg/kg D induces a marked and long-lasting increase in the threshold of nociceptive flexion reflex in healthy volunteers.
  2. 02HumanNon-randomized trialMechanism

    In humans, naloxone only partly reversed dermorphin-induced depression of the nociceptive spinal reflex, by approximately 50%.

    In plain wordsIn humans, naloxone only partly reversed dermorphin-induced suppression of a pain-related spinal reflex.

    Peptide
    Dermorphin
    Outcome
    Not applicablePartial naloxone reversal of spinal reflex depression
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    Reversal of depressive effect
    ≈ 50%
    naloxone after dermorphin

    Source sentences

    Summary
    Naloxone, while fully antagonizing the effects of morphine and enkephalin analogue, is able to reverse only partly (ca. 50%) the depressive effect of D on nociceptive spinal reflex.
    1 context sentence
    Summary · context
    Our study shows that i.v. infusion of 0.16 mg/kg D induces a marked and long-lasting increase in the threshold of nociceptive flexion reflex in healthy volunteers.
  3. 03HumanCase report or seriesEfficacy outcome

    In a complete chronic spinal subject, dermorphin also increased the nociceptive flexion reflex threshold.

    In plain wordsIn a person with a complete chronic spinal condition, dermorphin also raised the threshold for a pain-related reflex.

    Peptide
    Dermorphin
    Outcome
    IncreaseNociceptive flexion reflex threshold in spinal subject
    Study

    n = 1

    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    0.16 mg/kg · intravenous infusionAs given in this study (human).

    Source sentences

    Summary
    This effect is also evident in a complete chronic spinal subject, showing that D depresses the nociceptive transmission mainly acting at spinal level.
    1 context sentence
    Summary · context
    Our study shows that i.v. infusion of 0.16 mg/kg D induces a marked and long-lasting increase in the threshold of nociceptive flexion reflex in healthy volunteers.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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