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Study · Measured the body's own peptide · 1987

6 results

Oxytocin responses to stress in lactating and hyperprolactinaemic rats.

Carter DA, Lightman SL

Neuroendocrinology1 Dec 1987Cited by 59 (Europe PMC)

PMID3696384 (opens in a new tab)DOI10.1159/000124876 (opens in a new tab)PepBankPUB-03696384
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Natural levels measured6

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In virgin female rats, brief immobilization raised plasma oxytocin compared with controls.

    In plain wordsIn virgin female rats, stress raised the body's own oxytocin in blood compared with unstressed rats.

    Peptide
    Oxytocin
    Outcome
    IncreasePlasma oxytocin response to brief immobilization in virgin rats
    Study

    ratn: not reported in source

    Comparator
    Non-immobilized controls
    Outcome group
    Stress hormones · Endocrine and hormones

    Measurements

    Plasma OT, immobilized
    24.7 pmol/l
    virgin rats
    Plasma OT, controls
    7.7 pmol/l
    virgin rats

    Source sentences

    Summary
    In virgin rats, brief immobilization was associated with a significant elevation of plasma OT to 24.7 +/- 3.7 pmol/l compared with 7.7 +/- 1.1 pmol/l in controls.
    1 context sentence
    Summary · context
    The plasma oxytocin (OT) response to acute stress was compared between virgin, lactating, and hyperprolactinaemic female rats.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In lactating rats 6 days post-partum, the oxytocin stress response was absent.

    In plain wordsIn lactating rats, stress did not raise the body's own oxytocin in blood.

    Peptide
    Oxytocin
    Outcome
    No significant changePlasma oxytocin stress response in lactating rats
    Study

    ratn: not reported in source

    Comparator
    Non-immobilized controls
    Outcome group
    Stress hormones · Endocrine and hormones

    Measurements

    Plasma OT, controls
    9.4 pmol/l
    lactating rats
    Plasma OT, immobilized
    9 pmol/l
    lactating rats

    Source sentences

    Summary
    In contrast, the stress response was absent in lactating (6 days post-partum) animals: control OT 9.4 +/- 2.2, immobilized OT 9.0 +/- 1.1 pmol/l.
    1 context sentence
    Summary · context
    The plasma oxytocin (OT) response to acute stress was compared between virgin, lactating, and hyperprolactinaemic female rats.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In intact female rats, hyperprolactinaemia produced by dopamine antagonists or ovine prolactin was associated with an impaired oxytocin stress response.

    In plain wordsIn female rats, high prolactin was linked to a weaker rise in the body's own oxytocin under stress.

    Peptide
    Oxytocin
    Outcome
    DecreaseOxytocin stress response with hyperprolactinaemia in intact females
    Study

    ratn: not reported in source

    Comparator
    Untreated females
    Outcome group
    Stress hormones · Endocrine and hormones

    Source sentences

    Summary
    Hyperprolactinaemia produced by treatment with either dopamine antagonists (domperidone or haloperidol) or ovine prolactin was also associated with an impairment of the OT stress response in intact females
    1 context sentence
    Summary · context
    The plasma oxytocin (OT) response to acute stress was compared between virgin, lactating, and hyperprolactinaemic female rats.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04AnimalEndogenous levelAnimal study (in vivo)Other

    In ovariectomized rats, domperidone treatment failed to modify the oxytocin stress response.

    In plain wordsIn rats with ovaries removed, domperidone did not change the rise in the body's own oxytocin under stress.

    Peptide
    Oxytocin
    Outcome
    No significant changeOxytocin stress response after domperidone in ovariectomized rats
    Study

    ratn: not reported in source

    Comparator
    Untreated ovariectomized rats
    Outcome group
    Stress hormones · Endocrine and hormones

    Source sentences

    Summary
    whereas domperidone treatment failed to modify the response in ovariectomized (OVX) rats.
    1 context sentence
    Summary · context
    The plasma oxytocin (OT) response to acute stress was compared between virgin, lactating, and hyperprolactinaemic female rats.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  5. 05AnimalEndogenous levelAnimal study (in vivo)Other

    In ovariectomized rats given oestradiol and progesterone, the inhibitory effect of domperidone on the oxytocin stress response was observed.

    In plain wordsIn rats with ovaries removed and given hormone replacement, domperidone weakened the rise in the body's own oxytocin under stress.

    Peptide
    Oxytocin
    Outcome
    DecreaseOxytocin stress response with domperidone after steroid replacement
    Study

    ratn: not reported in source

    Outcome group
    Stress hormones · Endocrine and hormones

    Measurements

    Plasma OT, controls
    11.1 pmol/l
    OVX, steroids
    Plasma OT, immobilized
    16 pmol/l
    OVX, steroids

    Source sentences

    Summary
    Following ovarian steroid replacement with oestradiol and progesterone, the inhibitory effect of domperidone was observed in OVX rats: control OT 11.1 +/- 2.5, immobilized OT 16.0 +/- 3.7 pmol/l.
    1 context sentence
    Summary · context
    The plasma oxytocin (OT) response to acute stress was compared between virgin, lactating, and hyperprolactinaemic female rats.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  6. 06AnimalEndogenous levelAnimal study (in vivo)Other

    In ovariectomized rats, oestradiol and progesterone, separately or combined, did not modify the oxytocin stress response.

    In plain wordsIn rats with ovaries removed, oestradiol and progesterone did not change the rise in the body's own oxytocin under stress.

    Peptide
    Oxytocin
    Outcome
    No significant changeOxytocin stress response after oestradiol and progesterone
    Study

    ratn: not reported in source

    Comparator
    Untreated ovariectomized rats
    Outcome group
    Stress hormones · Endocrine and hormones

    Source sentences

    Summary
    Treatment of OVX rats with oestradiol and progesterone, either separately or combined, did not modify the OT stress response.
    1 context sentence
    Summary · context
    The plasma oxytocin (OT) response to acute stress was compared between virgin, lactating, and hyperprolactinaemic female rats.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:53 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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