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Study · Animal study (in vivo) · rat · 1987

5 results

The effects of DSIP on pain threshold during light and dark periods in rats are not naloxone-sensitive.

Yehuda S, Carasso RL

The International journal of neuroscience1 Nov 1987Cited by 3 (Europe PMC)

PMID3679693 (opens in a new tab)DOI10.3109/00207458708991805 (opens in a new tab)PepBankPUB-03679693
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, DSIP at 0.1 mg/kg intraperitoneally significantly raised the hot-plate pain threshold in both the light and dark periods.

    In plain wordsIn rats, DSIP raised the pain threshold in both the light and dark periods.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreasePain threshold (hot plate), light and dark periods, 0.1 mg/kg
    Study

    ratn: not reported in source

    Comparator
    Saline
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    0.1 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Rats treated with 0.1 mg/kg, i.p. DSIP exhibited a significantly higher pain threshold level (as measured by hot plate) both in the light and dark periods.
    1 context sentence
    Summary · context
    The effects of Delta-Sleep-Induced Peptide (DSIP) were examined in rats kept at 12:12 light:dark schedule.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, DSIP at 1.0 mg/kg raised the pain threshold during the dark period.

    In plain wordsIn rats, a higher DSIP dose raised the pain threshold during the dark period.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreasePain threshold, dark period, 1.0 mg/kg
    Study

    ratn: not reported in source

    Comparator
    Saline
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    1.0 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    A dose of 1.0 mg/kg DSIP increased the pain threshold level only during the dark period.
    1 context sentence
    Summary · context
    The effects of Delta-Sleep-Induced Peptide (DSIP) were examined in rats kept at 12:12 light:dark schedule.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, DSIP at 1.0 mg/kg did not raise the pain threshold during the light period.

    In plain wordsIn rats, a higher DSIP dose did not raise the pain threshold during the light period.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changePain threshold, light period, 1.0 mg/kg
    Study

    ratn: not reported in source

    Comparator
    Saline
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    1.0 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    A dose of 1.0 mg/kg DSIP increased the pain threshold level only during the dark period.
    1 context sentence
    Summary · context
    The effects of Delta-Sleep-Induced Peptide (DSIP) were examined in rats kept at 12:12 light:dark schedule.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats, with DSIP treatment the peak of the circadian pain threshold shifted from 10:00 to 18:00.

    In plain wordsIn rats, DSIP treatment moved the daily peak of the pain threshold to a later time.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicablePeak time of circadian pain threshold
    Study

    ratn: not reported in source

    Comparator
    Before treatment
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    With treatment the peak shifted to 18:00.
    2 context sentences
    Summary · context
    Prior to the treatment the peak was at 10:00.
    Summary · context
    The effects of Delta-Sleep-Induced Peptide (DSIP) were examined in rats kept at 12:12 light:dark schedule.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats, DSIP-induced analgesia was insensitive to naloxone pretreatment.

    In plain wordsIn rats, the pain relief from DSIP was not blocked by naloxone.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeNaloxone sensitivity of DSIP analgesia
    Study

    ratn: not reported in source

    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The analgesia induced by DSIP is insensitive to naloxone pretreatment.
    1 context sentence
    Summary · context
    The effects of Delta-Sleep-Induced Peptide (DSIP) were examined in rats kept at 12:12 light:dark schedule.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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