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Study · Animal study (in vivo) · mouse · 1987

4 results

Oxytocin acts as an antidepressant in two animal models of depression.

Arletti R, Bertolini A

Life sciences1 Oct 1987Cited by 165 (Europe PMC)

PMID3657379 (opens in a new tab)DOI10.1016/0024-3205(87)90600-x (opens in a new tab)PepBankPUB-03657379
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In the mouse behavioral despair test, oxytocin significantly reduced immobility time at 0.250-1.0 mg/Kg, with an effect similar to imipramine.

    In plain wordsIn mice, oxytocin shortened the time spent immobile in a despair test, similar to imipramine.

    Peptide
    Oxytocin
    Outcome
    DecreaseImmobility duration in behavioral despair test
    Study

    micen: not reported in source

    Behavioral despair test
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    0.250-1.0 mg/Kg · intraperitoneal · single dose 60 min before testingAs given in this study (mice).

    Source sentences

    Summary
    In the behavioral despair test in mice, oxytocin, i.p. injected 60 min before testing, significantly reduced the duration of immobility at doses of 0.250-1.0 mg/Kg; the effect being similar to that of imipramine (7.5-30 mg/Kg i.p.).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In the mouse behavioral despair test, a 10-day oxytocin treatment schedule gave a more powerful effect than the single dose.

    In plain wordsIn mice, ten days of oxytocin treatment had a stronger effect in the despair test than a single dose.

    Peptide
    Oxytocin
    Outcome
    DecreaseImmobility duration after 10-day treatment
    Study

    micen: not reported in source

    Behavioral despair test
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · intraperitoneal · 10 daysAs given in this study (mice).

    Source sentences

    Summary
    A more powerful effect was obtained with a 10-day treatment schedule.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In the learned helplessness test, oxytocin significantly reduced escape failures, more strongly than imipramine.

    In plain wordsIn a test of learned helplessness in animals, oxytocin cut escape failures, more than imipramine did.

    Peptide
    Oxytocin
    Outcome
    DecreaseEscape failures in learned helplessness test
    Study

    n: not reported in source

    Learned helplessness test
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    0.500 mg/Kg/day · intraperitoneal · 8 daysAs given in this study.

    Source sentences

    Summary
    In the learned helplessness test, oxytocin (0.500 mg/Kg/day i.p. for 8 days) significantly reduced the escape failures and the latency to escape, the effect being even more intense than that of imipramine (20 mg/Kg/day i.p. for 8 days).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In the learned helplessness test, oxytocin significantly reduced the latency to escape, more strongly than imipramine.

    In plain wordsIn a test of learned helplessness in animals, oxytocin shortened the time to escape, more than imipramine did.

    Peptide
    Oxytocin
    Outcome
    DecreaseEscape latency in learned helplessness test
    Study

    n: not reported in source

    Learned helplessness test
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    0.500 mg/Kg/day · intraperitoneal · 8 daysAs given in this study.

    Source sentences

    Summary
    In the learned helplessness test, oxytocin (0.500 mg/Kg/day i.p. for 8 days) significantly reduced the escape failures and the latency to escape, the effect being even more intense than that of imipramine (20 mg/Kg/day i.p. for 8 days).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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