In thymectomized mice, treatment with antisera to thymosin alpha‑1 did not remove dysgenic ovaries, and auto-oocyte antibody levels stayed similar to untreated Tx-3 mice.
In plain wordsIn mice, blocking thymosin alpha‑1 with antisera did not reverse ovarian damage or lower the antibody levels.
- Peptide
- Thymosin alpha-1
- Outcome
- No significant changeOvarian dysgenesis and auto-oocyte antibody after antisera to thymosin alpha 1
- Study
mousen: not reported in source
neonatally thymectomized B6A female mice (Tx-3) with autoimmune oophoritis- Comparator
- Untreated Tx-3 mice
- Outcome group
- Sex hormones and fertility · Reproductive and sexual health
Source sentences
After treatment of the Tx-3 mice, dysgenic ovaries persisted and high levels of AOA remained similar to the untreated Tx-3 mice.
1 context sentence(design, population, supporting numbers)
In the present study injections of antisera to TSN alpha 1 were given to Tx-3 mice in an attempt to decrease circulating TSN alpha 1 levels.
In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.