Protein and energy metabolism with biosynthetic human growth hormone after gastrointestinal surgery.

Ward HC, Halliday D, Sim AJ

Annals of surgery1 Jul 1987Cited by 134 (Europe PMC)

PMID3606231DOI10.1097/00000658-198707000-00009PepBankPUB-03606231

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. 10 results from people.

01HumanNon-randomized trialEfficacy outcome
After gastrointestinal surgery, BSHGH significantly reduced total nitrogen excretion versus placebo over six days.
In plain wordsAfter gastrointestinal surgery, BSHGH reduced nitrogen excretion more than placebo.
Peptide
HGH (somatotropin)
Outcome
DecreaseTotal nitrogen excretion
Study
n = 14
Comparator
Placebo
Outcome group
Protein and amino acid metabolism · Metabolic and weight
Studied dose
0.1 mg/kg/24 h · first six postoperative daysAs given in this study (human).
Measurements
Nitrogen excretion
31.5 g N
BSHGH; +/- 2.4
Nitrogen excretion
42.7 g N
placebo; +/- 3.1
Nitrogen excretion
2287 mmol
BSHGH; +/- 160
Nitrogen excretion
3049 mmol
placebo; +/- 219
Source sentences
Summary
Mean total nitrogen excretion was significantly lower with BSHGH (31.5 +/- 2.4 g N) (2287 +/- 160 mmol) than with placebo (42.7 +/- 3.1 g N) (3049 +/- 219 mmol) over the 6-day study period.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of biosynthetic human growth hormone (BSHGH) on postoperative protein and energy metabolism has been studied in patients who had major gastrointestinal surgery.
Summary · context
Seven patients received placebo and seven patients received BSHGH, 0.1 mg/kg/24 h, for the first six postoperative days.
Report a problemFND-0360623101
02HumanNon-randomized trialEfficacy outcome
After gastrointestinal surgery, BSHGH increased measured energy expenditure versus placebo on days 3-6.
In plain wordsAfter gastrointestinal surgery, BSHGH increased energy use compared with placebo.
Peptide
HGH (somatotropin)
Outcome
IncreaseEnergy expenditure
Study
n = 14
Comparator
Placebo
Outcome group
Energy expenditure and thermogenesis · Metabolic and weight
Studied dose
0.1 mg/kg/24 h · first six postoperative daysAs given in this study (human).
Measurements
Energy expenditure
31.3 kcal/kg LBM/24 h
BSHGH; +/- 1.8
Energy expenditure
27.6 kcal/kg LBM/24 h
placebo; +/- 0.8
Energy expenditure
131 kJ/kg LBM/24 h
BSHGH; +/- 7
Energy expenditure
114 kJ/kg LBM/24 h
placebo; +/- 2
Source sentences
Summary
The mean daily measured energy expenditure over days 3-6 was higher with BSHGH (31.3 +/- 1.8 kcal/kg LBM/24 h) (131 +/- 7 kJ/kg LBM/24 h) than with placebo (27.6 +/- 0.8 kcal/kg LBM/24 h) (114 +/- 2 kJ/kg LBM/24 h).
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of biosynthetic human growth hormone (BSHGH) on postoperative protein and energy metabolism has been studied in patients who had major gastrointestinal surgery.
Summary · context
Seven patients received placebo and seven patients received BSHGH, 0.1 mg/kg/24 h, for the first six postoperative days.
Report a problemFND-0360623102
03HumanNon-randomized trialEfficacy outcome
After gastrointestinal surgery, BSHGH increased fat oxidation versus placebo on days 1-6.
In plain wordsAfter gastrointestinal surgery, BSHGH increased fat oxidation compared with placebo.
Peptide
HGH (somatotropin)
Outcome
IncreaseFat oxidation
Study
n = 14
Comparator
Placebo
Outcome group
Lipids · Metabolic and weight
Studied dose
0.1 mg/kg/24 h · first six postoperative daysAs given in this study (human).
Measurements
Fat oxidation
2.05 mg/kg LBM/24 h
BSHGH; +/- 0.26
Fat oxidation
1.5 mg/kg LBM/24 h
placebo; +/- 0.17
Source sentences
Summary
Fat oxidation with BSHGH (2.05 +/- 0.26 mg/kg LBM/24 h) was greater than with placebo (1.5 +/- 0.17 mg/kg LBM/24 h) and protein oxidation was less with BSHGH (0.68 +/- 0.07 g/kg LBM/24 h) than with placebo (0.9 +/- 0.09 g/kg LBM/24 h) on days 1-6.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of biosynthetic human growth hormone (BSHGH) on postoperative protein and energy metabolism has been studied in patients who had major gastrointestinal surgery.
Summary · context
Seven patients received placebo and seven patients received BSHGH, 0.1 mg/kg/24 h, for the first six postoperative days.
Report a problemFND-0360623103
04HumanNon-randomized trialEfficacy outcome
After gastrointestinal surgery, BSHGH reduced protein oxidation versus placebo on days 1-6.
In plain wordsAfter gastrointestinal surgery, BSHGH reduced protein oxidation compared with placebo.
Peptide
HGH (somatotropin)
Outcome
DecreaseProtein oxidation
Study
n = 14
Comparator
Placebo
Outcome group
Protein and amino acid metabolism · Metabolic and weight
Studied dose
0.1 mg/kg/24 h · first six postoperative daysAs given in this study (human).
Measurements
Protein oxidation
0.68 g/kg LBM/24 h
BSHGH; +/- 0.07
Protein oxidation
0.9 g/kg LBM/24 h
placebo; +/- 0.09
Source sentences
Summary
Fat oxidation with BSHGH (2.05 +/- 0.26 mg/kg LBM/24 h) was greater than with placebo (1.5 +/- 0.17 mg/kg LBM/24 h) and protein oxidation was less with BSHGH (0.68 +/- 0.07 g/kg LBM/24 h) than with placebo (0.9 +/- 0.09 g/kg LBM/24 h) on days 1-6.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of biosynthetic human growth hormone (BSHGH) on postoperative protein and energy metabolism has been studied in patients who had major gastrointestinal surgery.
Summary · context
Seven patients received placebo and seven patients received BSHGH, 0.1 mg/kg/24 h, for the first six postoperative days.
Report a problemFND-0360623104
05HumanNon-randomized trialEfficacy outcome
After gastrointestinal surgery, BSHGH increased nitrogen turnover versus placebo.
In plain wordsAfter gastrointestinal surgery, BSHGH increased nitrogen turnover compared with placebo.
Peptide
HGH (somatotropin)
Outcome
IncreaseNitrogen turnover
Study
n = 14
Comparator
Placebo
Outcome group
Protein and amino acid metabolism · Metabolic and weight
Studied dose
0.1 mg/kg/24 h · first six postoperative daysAs given in this study (human).
Measurements
Nitrogen turnover
943 mg N/kg LBM/24 h
BSHGH; +/- 174
Nitrogen turnover
557 mg N/kg LBM/24 h
placebo; +/- 50
Nitrogen turnover
67 mmol/kg LBM/24 h
BSHGH; +/- 13
Nitrogen turnover
40 mmol/kg LBM/24 h
placebo; +/- 4
Source sentences
Summary
Postoperative nitrogen turnover (BSHGH 943 +/- 174 mg N/kg LBM/24 h, placebo 557 +/- 50 mg N/kg LBM/24 h) (BSHGH 67 +/- 13 mmol/kg LBM/24 h, placebo 40 +/- 4 mmol/kg LBM/24 h)
3 context sentences(design, population, supporting numbers)
Summary · context
were greater with BSHGH.
Summary · context
The effect of biosynthetic human growth hormone (BSHGH) on postoperative protein and energy metabolism has been studied in patients who had major gastrointestinal surgery.
Summary · context
Seven patients received placebo and seven patients received BSHGH, 0.1 mg/kg/24 h, for the first six postoperative days.
Report a problemFND-0360623105
06HumanNon-randomized trialEfficacy outcome
After gastrointestinal surgery, BSHGH increased protein synthesis versus placebo.
In plain wordsAfter gastrointestinal surgery, BSHGH increased protein synthesis compared with placebo.
Peptide
HGH (somatotropin)
Outcome
IncreaseProtein synthesis
Study
n = 14
Comparator
Placebo
Outcome group
Protein and amino acid metabolism · Metabolic and weight
Studied dose
0.1 mg/kg/24 h · first six postoperative daysAs given in this study (human).
Measurements
Protein synthesis
5.31 g prot/kg LBM/24 h
BSHGH; +/- 1.09
Protein synthesis
2.54 g prot/kg LBM/24 h
placebo; +/- 0.33
Source sentences
Summary
protein synthesis (BSHGH 5.31 +/- 1.09 g prot/kg LBM/24 h, placebo 2.54 +/- 0.33 g prot/kg LBM/24 h) and protein breakdown (BSHGH 5.90 +/- 1.09 g prot/kg LBM/24 h, placebo 3.48 +/- 0.31 g prot/kg LBM/24 h) were greater with BSHGH.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of biosynthetic human growth hormone (BSHGH) on postoperative protein and energy metabolism has been studied in patients who had major gastrointestinal surgery.
Summary · context
Seven patients received placebo and seven patients received BSHGH, 0.1 mg/kg/24 h, for the first six postoperative days.
Report a problemFND-0360623106
07HumanNon-randomized trialEfficacy outcome
After gastrointestinal surgery, BSHGH increased protein breakdown versus placebo.
In plain wordsAfter gastrointestinal surgery, BSHGH increased protein breakdown compared with placebo.
Peptide
HGH (somatotropin)
Outcome
IncreaseProtein breakdown
Study
n = 14
Comparator
Placebo
Outcome group
Protein and amino acid metabolism · Metabolic and weight
Studied dose
0.1 mg/kg/24 h · first six postoperative daysAs given in this study (human).
Measurements
Protein breakdown
5.9 g prot/kg LBM/24 h
BSHGH; +/- 1.09
Protein breakdown
3.48 g prot/kg LBM/24 h
placebo; +/- 0.31
Source sentences
Summary
protein breakdown (BSHGH 5.90 +/- 1.09 g prot/kg LBM/24 h, placebo 3.48 +/- 0.31 g prot/kg LBM/24 h) were greater with BSHGH.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of biosynthetic human growth hormone (BSHGH) on postoperative protein and energy metabolism has been studied in patients who had major gastrointestinal surgery.
Summary · context
Seven patients received placebo and seven patients received BSHGH, 0.1 mg/kg/24 h, for the first six postoperative days.
Report a problemFND-0360623107
08HumanNon-randomized trialEfficacy outcome
After gastrointestinal surgery, BSHGH increased serum insulin versus placebo on the first postoperative day.
In plain wordsAfter gastrointestinal surgery, BSHGH increased insulin compared with placebo on the first postoperative day.
Peptide
HGH (somatotropin)
Outcome
IncreaseSerum insulin
Study
n = 14
Comparator
Placebo
Outcome group
Glycemic control · Metabolic and weight
Studied dose
0.1 mg/kg/24 h · first six postoperative daysAs given in this study (human).
Source sentences
Summary
On the first postoperative day serum insulin and blood glucose levels were higher with BSHGH than with placebo, and on days 4 and 7 serum somatomedin-C levels were significantly elevated.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of biosynthetic human growth hormone (BSHGH) on postoperative protein and energy metabolism has been studied in patients who had major gastrointestinal surgery.
Summary · context
Seven patients received placebo and seven patients received BSHGH, 0.1 mg/kg/24 h, for the first six postoperative days.
Report a problemFND-0360623108
09HumanNon-randomized trialEfficacy outcome
After gastrointestinal surgery, BSHGH increased blood glucose versus placebo on the first postoperative day.
In plain wordsAfter gastrointestinal surgery, BSHGH increased blood glucose compared with placebo on the first postoperative day.
Peptide
HGH (somatotropin)
Outcome
IncreaseBlood glucose
Study
n = 14
Comparator
Placebo
Outcome group
Glycemic control · Metabolic and weight
Studied dose
0.1 mg/kg/24 h · first six postoperative daysAs given in this study (human).
Source sentences
Summary
On the first postoperative day serum insulin and blood glucose levels were higher with BSHGH than with placebo, and on days 4 and 7 serum somatomedin-C levels were significantly elevated.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of biosynthetic human growth hormone (BSHGH) on postoperative protein and energy metabolism has been studied in patients who had major gastrointestinal surgery.
Summary · context
Seven patients received placebo and seven patients received BSHGH, 0.1 mg/kg/24 h, for the first six postoperative days.
Report a problemFND-0360623109
10HumanNon-randomized trialEfficacy outcome
After gastrointestinal surgery, BSHGH significantly elevated serum somatomedin-C on days 4 and 7.
In plain wordsAfter gastrointestinal surgery, BSHGH increased somatomedin-C on days 4 and 7.
Peptide
HGH (somatotropin)
Outcome
IncreaseSomatomedin-C
Study
n = 14
Comparator
Placebo
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
0.1 mg/kg/24 h · first six postoperative daysAs given in this study (human).
Source sentences
Summary
On the first postoperative day serum insulin and blood glucose levels were higher with BSHGH than with placebo, and on days 4 and 7 serum somatomedin-C levels were significantly elevated.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of biosynthetic human growth hormone (BSHGH) on postoperative protein and energy metabolism has been studied in patients who had major gastrointestinal surgery.
Summary · context
Seven patients received placebo and seven patients received BSHGH, 0.1 mg/kg/24 h, for the first six postoperative days.
Report a problemFND-0360623110

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PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:37 UTC
First added · source update from Europe PMC

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