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Study · Animal study (in vivo) · rat · 1987

2 results

Gap junction modulation in rat uterus. III. Structure-activity relationships of estrogen receptor-binding ligands on myometrial and serosal cells.

Burghardt RC, Gaddy-Kurten D, Burghardt RL, Kurten RC, Mitchell PA

Biology of reproduction1 Apr 1987Cited by 6 (Europe PMC)

PMID3593845 (opens in a new tab)DOI10.1095/biolreprod36.3.741 (opens in a new tab)PepBankPUB-03593845
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In hypophysectomized rats, enclomiphene did not induce myometrial gap junctions.

    In plain wordsIn rats, enclomiphene did not induce gap junctions in uterine muscle cells.

    Peptide
    Enclomiphene
    Outcome
    No significant changeMyometrial gap junction induction
    Study

    ratn: not reported in source

    Hypophysectomized rat uterus
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Of the triphenylethylene derivatives and related compounds evaluated, including mixed isomers of tamoxifen and CI 628, the cis (zuclomiphene, ZUC) and trans (enclomiphene) isomers of clomiphene citrate, and a fixed-ring antiestrogen, nafoxidine, only ZUC was able to induce gap junctions in myometrial and serosal cells.
    1 context sentence
    Summary · context
    A number of steroidal and nonsteroidal estrogen receptor-binding ligands were tested for their ability to affect the formation and internalization of gap junctions in hypophysectomized rat uterine myometrial and serosal cells.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In hypophysectomized rats, enclomiphene did not induce serosal gap junctions.

    In plain wordsIn rats, enclomiphene did not induce gap junctions in uterine serosal cells.

    Peptide
    Enclomiphene
    Outcome
    No significant changeSerosal gap junction induction
    Study

    ratn: not reported in source

    Hypophysectomized rat uterus
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Of the triphenylethylene derivatives and related compounds evaluated, including mixed isomers of tamoxifen and CI 628, the cis (zuclomiphene, ZUC) and trans (enclomiphene) isomers of clomiphene citrate, and a fixed-ring antiestrogen, nafoxidine, only ZUC was able to induce gap junctions in myometrial and serosal cells.
    1 context sentence
    Summary · context
    A number of steroidal and nonsteroidal estrogen receptor-binding ligands were tested for their ability to affect the formation and internalization of gap junctions in hypophysectomized rat uterine myometrial and serosal cells.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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