In rat liver nuclear binding assays, enclomiphene relative binding affinity at TABS did not differ from tamoxifen.
In plain wordsIn lab tests with rat liver binding sites, enclomiphene binding affinity did not differ from tamoxifen.
- Peptide
- Enclomiphene
- Outcome
- No significant changeRelative binding affinity at TABS
- Study
ratn: not reported in source
Liver nuclear triphenylethylene antiestrogen binding sites- Comparator
- Tamoxifen
- Outcome group
- Receptor activity and mechanism · Pharmacology
- Studied dose
- Dose not stated
Source sentences
Nafoxidine was the most effective triphenylethylene compound used (RBA 333; Kd approximately 0.3 nM) whereas the RBA of zuclomiphene and enclomiphene was not different from tamoxifen.
1 context sentence(design, population, supporting numbers)
The ability of tamoxifen to inhibit the binding of [3H]tamoxifen to salt extracted (0.4 M KCl) TABS from rat liver nuclei was used as a standard by which other compounds were compared (tamoxifen RBA, 100; Kd approximately 1 nM).