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Study · Animal study (in vivo) · rat · 1987

6 results

Effect of dermorphin and morphine on the sympathetic and cardiovascular system of the pithed rat.

Feuerstein G, Zukowska-Grojec Z

Neuropeptides1 Feb 1987Cited by 11 (Europe PMC)

PMID3574608 (opens in a new tab)DOI10.1016/0143-4179(87)90052-7 (opens in a new tab)PepBankPUB-03574608
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In pithed rats, dermorphin had no effect on basal heart rate.

    In plain wordsIn pithed rats, dermorphin did not change resting heart rate.

    Peptide
    Dermorphin
    Outcome
    No significant changeBasal heart rate
    Study

    ratn: not reported in source

    pithed rat
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    0.0001-10 mumol/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Dermorphin (0.0001-10 mumol/kg, i.v) or morphine (1-10 mg/kg) had no effect on basal heart rate or blood pressure and failed to modify sympatho-adreno-medullary evoked pressor and tachycardic responses.
    1 context sentence
    Summary · context
    The purpose of this study was to examine the effect of intravenous dermorphin on heart rate and blood pressure of the pithed rat in basal condition and in response to controlled sympathetic stimulation.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In pithed rats, dermorphin had no effect on basal blood pressure.

    In plain wordsIn pithed rats, dermorphin did not change resting blood pressure.

    Peptide
    Dermorphin
    Outcome
    No significant changeBasal blood pressure
    Study

    ratn: not reported in source

    pithed rat
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    0.0001-10 mumol/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Dermorphin (0.0001-10 mumol/kg, i.v) or morphine (1-10 mg/kg) had no effect on basal heart rate or blood pressure and failed to modify sympatho-adreno-medullary evoked pressor and tachycardic responses.
    1 context sentence
    Summary · context
    The purpose of this study was to examine the effect of intravenous dermorphin on heart rate and blood pressure of the pithed rat in basal condition and in response to controlled sympathetic stimulation.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In pithed rats, dermorphin did not modify sympatho-adreno-medullary evoked pressor responses.

    In plain wordsIn pithed rats, dermorphin did not change blood pressure responses to sympathetic stimulation.

    Peptide
    Dermorphin
    Outcome
    No significant changeEvoked pressor response
    Study

    ratn: not reported in source

    pithed rat
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    0.0001-10 mumol/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Dermorphin (0.0001-10 mumol/kg, i.v) or morphine (1-10 mg/kg) had no effect on basal heart rate or blood pressure and failed to modify sympatho-adreno-medullary evoked pressor and tachycardic responses.
    1 context sentence
    Summary · context
    The purpose of this study was to examine the effect of intravenous dermorphin on heart rate and blood pressure of the pithed rat in basal condition and in response to controlled sympathetic stimulation.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In pithed rats, dermorphin did not modify sympatho-adreno-medullary evoked tachycardic responses.

    In plain wordsIn pithed rats, dermorphin did not change heart rate responses to sympathetic stimulation.

    Peptide
    Dermorphin
    Outcome
    No significant changeEvoked tachycardic response
    Study

    ratn: not reported in source

    pithed rat
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    0.0001-10 mumol/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Dermorphin (0.0001-10 mumol/kg, i.v) or morphine (1-10 mg/kg) had no effect on basal heart rate or blood pressure and failed to modify sympatho-adreno-medullary evoked pressor and tachycardic responses.
    1 context sentence
    Summary · context
    The purpose of this study was to examine the effect of intravenous dermorphin on heart rate and blood pressure of the pithed rat in basal condition and in response to controlled sympathetic stimulation.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In pithed rats, dermorphin did not affect the plasma norepinephrine increase after spinal cord stimulation.

    In plain wordsIn pithed rats, dermorphin did not change the norepinephrine rise after spinal cord stimulation.

    Peptide
    Dermorphin
    Outcome
    No significant changeStimulated plasma norepinephrine increase
    Study

    ratn: not reported in source

    pithed rat
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    0.0001-10 mumol/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Furthermore, dermorphin or morphine did not affect the increase in plasma norepinephrine and epinephrine in response to spinal cord stimulation.
    1 context sentence
    Summary · context
    The purpose of this study was to examine the effect of intravenous dermorphin on heart rate and blood pressure of the pithed rat in basal condition and in response to controlled sympathetic stimulation.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In pithed rats, dermorphin did not affect the plasma epinephrine increase after spinal cord stimulation.

    In plain wordsIn pithed rats, dermorphin did not change the epinephrine rise after spinal cord stimulation.

    Peptide
    Dermorphin
    Outcome
    No significant changeStimulated plasma epinephrine increase
    Study

    ratn: not reported in source

    pithed rat
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    0.0001-10 mumol/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Furthermore, dermorphin or morphine did not affect the increase in plasma norepinephrine and epinephrine in response to spinal cord stimulation.
    1 context sentence
    Summary · context
    The purpose of this study was to examine the effect of intravenous dermorphin on heart rate and blood pressure of the pithed rat in basal condition and in response to controlled sympathetic stimulation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

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