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Study · Animal study (in vivo) · rat · 1987

1 result

Structure-activity relationship of dermorphin on gastric secretion.

Guglietta A, Irons BJ, Lazarus LH, Melchiorri P

Endocrinology1 May 1987Cited by 12 (Europe PMC)

PMID3569127 (opens in a new tab)DOI10.1210/endo-120-5-2137 (opens in a new tab)PepBankPUB-03569127
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, native dermorphin significantly reduced gastric acid output after injection.

    In plain wordsIn rats, native dermorphin reduced stomach acid output after injection.

    Peptide
    Dermorphin
    Outcome
    DecreaseGastric acid output
    Study

    ratn: not reported in source

    rats
    Outcome group
    Gastrointestinal function · Gastrointestinal
    Studied dose
    Dose not stated · intracerebroventricular · 2 hAs given in this study (rat).

    Source sentences

    Summary
    DM, DM N-terminal pentapeptide and tetrapeptide amides, [D-Met2]DM, [Sar4]DM, [Trp5]DM, [Phe5]DM, [Gly7]DM, [Ser(Bzl)7]DM, and deamidated-DM significantly (P less than 0.01) reduced gastric acid output 2 h after injection.
    2 context sentences
    Summary · context
    The amphibian skin heptapeptide dermorphin (DM) administered intracerebroventricularly to rats significantly reduces gastric secretion.
    Summary · context
    Dermorphin and 19 DM homologs and analogs were tested for their effect on gastric volume, pH, H+ ion concentration, and gastric acid output.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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