DSIP affects adrenergic stimulation of rat pineal N-acetyltransferase in vivo and in vitro.

Graf MV, Schoenenberger GA

Peptides1 Nov 1986Cited by 8 (Europe PMC)

PMID3562314DOI10.1016/0196-9781(86)90128-2PepBankPUB-03562314

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats, subcutaneous DSIP reduced the stimulation of pineal N-acetyltransferase by isoproterenol and phenylephrine.
In plain wordsIn rats, DSIP injected under the skin reduced the rise of a pineal enzyme caused by adrenergic drugs.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseAdrenergic stimulation of pineal NAT in vivo
Study
ratn: not reported in source
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
150 and 300 micrograms/kg · subcutaneousAs given in this study (rat).
Source sentences
Summary
Stimulation of the enzyme with adrenergic drugs such as isoproterenol and phenylephrine was reduced by DSIP at doses of 150 and 300 micrograms/kg injected subcutaneously.
1 context sentence(design, population, supporting numbers)
Summary · context
The recent finding that DSIP influences the nocturnal rise of N-acetyltransferase (NAT) activity in rat pineal led us to investigate a possible effect on pharmacologically induced NAT activity in vivo and in vitro.
Report a problemFND-0356231401
02AnimalAnimal study (in vivo)Efficacy outcome
In rats, DSIP alone produced a slight stimulation of pineal N-acetyltransferase activity in vivo.
In plain wordsIn rats, DSIP alone caused a slight rise in the activity of a pineal enzyme.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseNAT activity with DSIP alone in vivo
Study
ratn: not reported in source
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
but produced a slight stimulation in vivo.
1 context sentence(design, population, supporting numbers)
Summary · context
The recent finding that DSIP influences the nocturnal rise of N-acetyltransferase (NAT) activity in rat pineal led us to investigate a possible effect on pharmacologically induced NAT activity in vivo and in vitro.
Report a problemFND-0356231405
03LabEx vivo tissueEfficacy outcome
In cultured rat pineals, DSIP attenuated isoproterenol stimulation of N-acetyltransferase.
In plain wordsIn lab tests on rat pineal glands, DSIP reduced the rise of an enzyme caused by isoproterenol.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseIsoproterenol stimulation of NAT in cultured pineals
Study
ratn: not reported in source
cultured pineals
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
6, 150 and 300 nMAs given in this study (rat).
Source sentences
Summary
In vitro, 6, 150 and 300 nM DSIP attenuated isoproterenol stimulation of the enzyme in cultured pineals
1 context sentence(design, population, supporting numbers)
Summary · context
The recent finding that DSIP influences the nocturnal rise of N-acetyltransferase (NAT) activity in rat pineal led us to investigate a possible effect on pharmacologically induced NAT activity in vivo and in vitro.
Report a problemFND-0356231402
04LabEx vivo tissueEfficacy outcome
In cultured rat pineals, 150 nM DSIP effectively reduced N-acetyltransferase stimulation induced by a combination of isoproterenol and phenylephrine.
In plain wordsIn lab tests on rat pineal glands, DSIP reduced the enzyme rise caused by two adrenergic drugs together.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseNAT stimulation by isoproterenol plus phenylephrine in cultured pineals
Study
ratn: not reported in source
cultured pineals
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
150 nMAs given in this study (rat).
Source sentences
Summary
whereas 150 nM DSIP effectively reduced stimulation induced by a combination of the two drugs.
1 context sentence(design, population, supporting numbers)
Summary · context
The recent finding that DSIP influences the nocturnal rise of N-acetyltransferase (NAT) activity in rat pineal led us to investigate a possible effect on pharmacologically induced NAT activity in vivo and in vitro.
Report a problemFND-0356231403
05LabEx vivo tissueEfficacy outcome
In cultured rat pineals, DSIP alone did not influence N-acetyltransferase activity.
In plain wordsIn lab tests on rat pineal glands, DSIP alone did not change the enzyme activity.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeNAT activity with DSIP alone in vitro
Study
ratn: not reported in source
cultured pineals
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
The peptide alone did not influence NAT activity in vitro
1 context sentence(design, population, supporting numbers)
Summary · context
The recent finding that DSIP influences the nocturnal rise of N-acetyltransferase (NAT) activity in rat pineal led us to investigate a possible effect on pharmacologically induced NAT activity in vivo and in vitro.
Report a problemFND-0356231404

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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