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Study · Ex vivo tissue · 1986

3 results

Oxytocin in human follicular fluid and its possible role in the ovulatory process as studied in vitro.

Tjugum J, Norström A, Dennefors B, Lundin S

Human reproduction (Oxford, England)1 Aug 1986Cited by 5 (Europe PMC)

PMID3558770 (opens in a new tab)DOI10.1093/oxfordjournals.humrep.a136405 (opens in a new tab)PepBankPUB-03558770
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In isolated human follicular wall, oxytocin decreased [3H]proline incorporation in unripe and pre-ovulatory follicles, indicating inhibited collagen synthesis.

    In plain wordsIn lab tests on human follicle tissue, oxytocin reduced a marker of collagen production.

    Peptide
    Oxytocin
    Outcome
    Decrease[3H]proline incorporation in follicular wall (collagen synthesis)
    Study

    humann: not reported in source

    isolated human follicular wall
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Oxytocin induced a decrease of radiolabelling in both unripe and pre-ovulatory follicles, indicating an inhibitory effect on collagen synthesis.
    1 context sentence
    Summary · context
    The influence of oxytocin on the incorporation of [3H]proline into isolated human follicular wall was studied in vitro.
  2. 02LabEx vivo tissueMechanism

    In isolated human follicular wall, the oxytocin effect on [3H]proline incorporation was not affected by indomethacin.

    In plain wordsIn lab tests on human follicle tissue, the drug indomethacin did not change the effect of oxytocin on collagen production.

    Peptide
    Oxytocin
    Outcome
    Not applicableEffect of indomethacin on the oxytocin effect on proline incorporation
    Study

    humann: not reported in source

    isolated human follicular wall
    Comparator
    Indomethacin
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This effect of oxytocin was not affected by indomethacin.
    1 context sentence
    Summary · context
    The influence of oxytocin on the incorporation of [3H]proline into isolated human follicular wall was studied in vitro.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 03HumanEndogenous levelObservational studyOther

    In human follicular fluid, the concentration of the body's own oxytocin was highest in pre-ovulatory follicles.

    In plain wordsIn women's follicular fluid, the body's own oxytocin level was highest in follicles close to ovulation.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin concentration in follicular fluid by follicle stage
    Study

    n: not reported in source

    human follicular fluid
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    The concentration of oxytocin was highest in pre-ovulatory follicles.
    1 context sentence
    Summary · context
    Oxytocin immunoreactivity was determined in follicular fluid from human follicles at different stages of development.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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