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Study · Non-randomized trial · n = 9 · 1987

7 results

Assessment of the biological effectiveness of nasal synthetic salmon calcitonin (SSCT) by comparison with intramuscular (i.m.) or placebo injection in normal subjects.

Reginster JY, Denis D, Albert A, Franchimont P

Bone and mineral1 Apr 1987Cited by 35 (Europe PMC)

PMID3504725 (opens in a new tab)PepBankPUB-03504725
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

  1. 01HumanNon-randomized trialActivity measurement

    In healthy subjects, nasal SSCT decreased serum calcium similarly to intramuscular SSCT.

    In plain wordsIn healthy subjects, nasal SSCT lowered blood calcium similarly to injected SSCT.

    Peptide
    Calcitonin-salmon
    Outcome
    DecreaseSerum calcium
    Study

    n = 9

    Comparator
    80 IU intramuscular SSCT
    Outcome group
    Calcium Metabolism · Endocrine and hormones
    Studied dose
    200 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    In nine healthy subjects, this instillation of 200 IU of SSCT into the nasal cavity caused a fall in serum calcium, a fall in serum phosphorus and a transient rise in parathyroid hormone levels similar to that observed after the intramuscular (i.m.) injection of 80 IU of SSCT.
    1 context sentence
    Summary · context
    The aim of this study was to assess, in normal subjects, the biological activity of nasal SSCT by comparing the fluctuations of parameters reflecting calcium-phosphorus metabolism after nasal instillation, injection of SSCT and injection of placebo, respectively.
  2. 02HumanNon-randomized trialActivity measurement

    In healthy subjects, nasal SSCT decreased serum phosphorus similarly to intramuscular SSCT.

    In plain wordsIn healthy subjects, nasal SSCT lowered blood phosphorus similarly to injected SSCT.

    Peptide
    Calcitonin-salmon
    Outcome
    DecreaseSerum phosphorus
    Study

    n = 9

    Comparator
    80 IU intramuscular SSCT
    Outcome group
    Calcium Metabolism · Endocrine and hormones
    Studied dose
    200 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    In nine healthy subjects, this instillation of 200 IU of SSCT into the nasal cavity caused a fall in serum calcium, a fall in serum phosphorus and a transient rise in parathyroid hormone levels similar to that observed after the intramuscular (i.m.) injection of 80 IU of SSCT.
    1 context sentence
    Summary · context
    The aim of this study was to assess, in normal subjects, the biological activity of nasal SSCT by comparing the fluctuations of parameters reflecting calcium-phosphorus metabolism after nasal instillation, injection of SSCT and injection of placebo, respectively.
  3. 03HumanNon-randomized trialActivity measurement

    In healthy subjects, nasal SSCT transiently increased parathyroid hormone similarly to intramuscular SSCT.

    In plain wordsIn healthy subjects, nasal SSCT briefly raised parathyroid hormone similarly to injected SSCT.

    Peptide
    Calcitonin-salmon
    Outcome
    IncreaseParathyroid hormone
    Study

    n = 9

    Comparator
    80 IU intramuscular SSCT
    Outcome group
    Calcium Metabolism · Endocrine and hormones
    Studied dose
    200 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    In nine healthy subjects, this instillation of 200 IU of SSCT into the nasal cavity caused a fall in serum calcium, a fall in serum phosphorus and a transient rise in parathyroid hormone levels similar to that observed after the intramuscular (i.m.) injection of 80 IU of SSCT.
    1 context sentence
    Summary · context
    The aim of this study was to assess, in normal subjects, the biological activity of nasal SSCT by comparing the fluctuations of parameters reflecting calcium-phosphorus metabolism after nasal instillation, injection of SSCT and injection of placebo, respectively.
  4. 04HumanNon-randomized trialActivity measurement

    In healthy subjects, nasal or injected SSCT did not inhibit endogenous calcitonin secretion.

    In plain wordsIn healthy subjects, nasal or injected SSCT did not suppress natural calcitonin secretion.

    Peptide
    Calcitonin-salmon
    Outcome
    Direction not reportedEndogenous calcitonin secretion
    Study

    n = 9

    Outcome group
    Calcium Metabolism · Endocrine and hormones
    Studied dose
    200 IU nasal; 80 IU intramuscular · nasal and intramuscularAs given in this study (human).

    Source sentences

    Summary
    SSCT whether administered by the nasal route or by injection, does not inhibit endogenous calcitonin secretion.
    Summary
    In nine healthy subjects, this instillation of 200 IU of SSCT into the nasal cavity caused a fall in serum calcium, a fall in serum phosphorus and a transient rise in parathyroid hormone levels similar to that observed after the intramuscular (i.m.) injection of 80 IU of SSCT.
    1 context sentence
    Summary · context
    The aim of this study was to assess, in normal subjects, the biological activity of nasal SSCT by comparing the fluctuations of parameters reflecting calcium-phosphorus metabolism after nasal instillation, injection of SSCT and injection of placebo, respectively.
  5. 05HumanNon-randomized trialActivity measurement

    In healthy subjects, serum beta-endorphin did not change after nasal or injected calcitonin.

    In plain wordsIn healthy subjects, nasal or injected calcitonin did not change blood beta-endorphin.

    Peptide
    Calcitonin-salmon
    Outcome
    No significant changeSerum beta-endorphin
    Study

    n = 9

    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    200 IU nasal; 80 IU intramuscular · nasal and intramuscularAs given in this study (human).

    Source sentences

    Summary
    There were no changes in serum beta-endorphin, magnesium or erythrocyte magnesium levels after administration of calcitonin by the intranasal route or by injection.
    Summary
    In nine healthy subjects, this instillation of 200 IU of SSCT into the nasal cavity caused a fall in serum calcium, a fall in serum phosphorus and a transient rise in parathyroid hormone levels similar to that observed after the intramuscular (i.m.) injection of 80 IU of SSCT.
    1 context sentence
    Summary · context
    The aim of this study was to assess, in normal subjects, the biological activity of nasal SSCT by comparing the fluctuations of parameters reflecting calcium-phosphorus metabolism after nasal instillation, injection of SSCT and injection of placebo, respectively.
  6. 06HumanNon-randomized trialActivity measurement

    In healthy subjects, serum magnesium did not change after nasal or injected calcitonin.

    In plain wordsIn healthy subjects, nasal or injected calcitonin did not change blood magnesium.

    Peptide
    Calcitonin-salmon
    Outcome
    No significant changeSerum magnesium
    Study

    n = 9

    Outcome group
    Calcium Metabolism · Endocrine and hormones
    Studied dose
    200 IU nasal; 80 IU intramuscular · nasal and intramuscularAs given in this study (human).

    Source sentences

    Summary
    There were no changes in serum beta-endorphin, magnesium or erythrocyte magnesium levels after administration of calcitonin by the intranasal route or by injection.
    Summary
    In nine healthy subjects, this instillation of 200 IU of SSCT into the nasal cavity caused a fall in serum calcium, a fall in serum phosphorus and a transient rise in parathyroid hormone levels similar to that observed after the intramuscular (i.m.) injection of 80 IU of SSCT.
    1 context sentence
    Summary · context
    The aim of this study was to assess, in normal subjects, the biological activity of nasal SSCT by comparing the fluctuations of parameters reflecting calcium-phosphorus metabolism after nasal instillation, injection of SSCT and injection of placebo, respectively.
  7. 07HumanNon-randomized trialActivity measurement

    In healthy subjects, erythrocyte magnesium did not change after nasal or injected calcitonin.

    In plain wordsIn healthy subjects, nasal or injected calcitonin did not change magnesium in red blood cells.

    Peptide
    Calcitonin-salmon
    Outcome
    No significant changeErythrocyte magnesium
    Study

    n = 9

    Outcome group
    Calcium Metabolism · Endocrine and hormones
    Studied dose
    200 IU nasal; 80 IU intramuscular · nasal and intramuscularAs given in this study (human).

    Source sentences

    Summary
    There were no changes in serum beta-endorphin, magnesium or erythrocyte magnesium levels after administration of calcitonin by the intranasal route or by injection.
    Summary
    In nine healthy subjects, this instillation of 200 IU of SSCT into the nasal cavity caused a fall in serum calcium, a fall in serum phosphorus and a transient rise in parathyroid hormone levels similar to that observed after the intramuscular (i.m.) injection of 80 IU of SSCT.
    1 context sentence
    Summary · context
    The aim of this study was to assess, in normal subjects, the biological activity of nasal SSCT by comparing the fluctuations of parameters reflecting calcium-phosphorus metabolism after nasal instillation, injection of SSCT and injection of placebo, respectively.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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