In human, guinea pig and rat lymphocyte cultures, oxytocin was inactive in all mitogenesis assays.
In plain wordsIn lab cultures of human, guinea pig and rat immune cells, oxytocin did not change cell growth.
- Peptide
- Oxytocin
- Outcome
- No significant changeLymphocyte DNA synthesis (3H-thymidine incorporation)
- Study
human, guinea pig, ratn: not reported in source
Lymphocytes from human thymus, guinea pig lymph nodes and rat spleen- Comparator
- No peptide
- Outcome group
- Immune response · Immune and inflammation
- Studied dose
- Dose not stated · 48 hAs given in this study (human, guinea pig, rat).
Source sentences
The following peptides were found to be inactive in all the above assays: substance P, cholecystokinin-octapeptide, somatostatin, galanin, oxytocin, pentagastrin and gastrin-releasing peptide 1-27 and 14-27.
2 context sentences(design, population, supporting numbers)
The effect of 15 defined neuropeptides on the mitogenic activation of lymphocytes from human thymus, guinea pig lymph nodes and rat spleen was investigated.
Lymphocytes were incubated in the absence or presence of polyclonal T and B cell activators together with increasing doses of the neuropeptides, and harvested at 48 h of culture after pulse-labeling with 3H-thymidine to assess the DNA synthesis.