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Study · Animal study (in vivo) · mouse · 1986

5 results

Thymosin alpha 1 enhances haemopoietic colony formation by stimulating the production of interleukin 3 in nu/nu mice.

Ohta Y, Tamura S, Nihira S, Tezuka E, Imai S, Yagi Y

International journal of immunopharmacology1 Jan 1986Cited by 7 (Europe PMC)

PMID3491057 (opens in a new tab)DOI10.1016/0192-0561(86)90014-7 (opens in a new tab)PepBankPUB-03491057
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In nu/nu mice, thymosin alpha‑1 increased haemopoietic colony formation measured as CFU-s.

    In plain wordsIn nude mice, thymosin alpha‑1 increased the number of blood stem cell colonies (CFU-s).

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseCFU-s colony formation
    Study

    mousen: not reported in source

    nu/nu mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · Twice a week, six or twelve administrationsAs given in this study (mouse).

    Source sentences

    Summary
    thymosin alpha 1 enhanced the colony formation as determined by CFU-s, GM-CFU and T-CFU, as well as the production of IL-3, when administered twice a week for a total of six or twelve times into nu/nu mice.
    1 context sentence
    Summary · context
    We have studied the action mechanism of thymosin alpha 1 in modulation of haemopoietic system.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In nu/nu mice, thymosin alpha‑1 increased haemopoietic colony formation measured as GM-CFU.

    In plain wordsIn nude mice, thymosin alpha‑1 increased the number of granulocyte-macrophage colonies (GM-CFU).

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseGM-CFU colony formation
    Study

    mousen: not reported in source

    nu/nu mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · Twice a week, six or twelve administrationsAs given in this study (mouse).

    Source sentences

    Summary
    thymosin alpha 1 enhanced the colony formation as determined by CFU-s, GM-CFU and T-CFU, as well as the production of IL-3, when administered twice a week for a total of six or twelve times into nu/nu mice.
    1 context sentence
    Summary · context
    We have studied the action mechanism of thymosin alpha 1 in modulation of haemopoietic system.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In nu/nu mice, thymosin alpha‑1 increased haemopoietic colony formation measured as T-CFU.

    In plain wordsIn nude mice, thymosin alpha‑1 increased the number of T cell colonies (T-CFU).

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseT-CFU colony formation
    Study

    mousen: not reported in source

    nu/nu mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · Twice a week, six or twelve administrationsAs given in this study (mouse).

    Source sentences

    Summary
    thymosin alpha 1 enhanced the colony formation as determined by CFU-s, GM-CFU and T-CFU, as well as the production of IL-3, when administered twice a week for a total of six or twelve times into nu/nu mice.
    1 context sentence
    Summary · context
    We have studied the action mechanism of thymosin alpha 1 in modulation of haemopoietic system.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In nu/nu mice, thymosin alpha‑1 increased the production of interleukin-3.

    In plain wordsIn nude mice, thymosin alpha‑1 increased production of interleukin-3.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseInterleukin-3 production
    Study

    mousen: not reported in source

    nu/nu mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · Twice a week, six or twelve administrationsAs given in this study (mouse).

    Source sentences

    Summary
    thymosin alpha 1 enhanced the colony formation as determined by CFU-s, GM-CFU and T-CFU, as well as the production of IL-3, when administered twice a week for a total of six or twelve times into nu/nu mice.
    1 context sentence
    Summary · context
    We have studied the action mechanism of thymosin alpha 1 in modulation of haemopoietic system.
  5. 05LabIn vitro (cells)Efficacy outcome

    Incubating bone marrow cells with thymosin alpha‑1 in vitro did not increase CFU-s, whereas IL-3 caused a marked increase.

    In plain wordsIn cells, thymosin alpha‑1 did not increase blood stem cell colonies directly, while interleukin-3 did.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeCFU-s after in vitro incubation of bone marrow cells
    Study

    mousen: not reported in source

    Mouse bone marrow cells
    Comparator
    Interleukin-3
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · 72 hAs given in this study (mouse).

    Source sentences

    Summary
    The incubation of bone marrow cells with thymosin alpha 1 in vitro did not cause an increase of CFU-s, in contrast to IL-3 which caused a marked increase of CFU-s during the incubation of 72 h.
    1 context sentence
    Summary · context
    We have studied the action mechanism of thymosin alpha 1 in modulation of haemopoietic system.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

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