Suppression of cellular immunity by head and neck irradiation. Precipitating factors and reparative mechanisms in an experimental model.

Gray WC, Hasslinger BJ, Suter CM, Blanchard CL, Goldstein AL, Chretien PB

Archives of otolaryngology--head & neck surgery1 Nov 1986Cited by 6 (Europe PMC)

PMID3489472DOI10.1001/archotol.1986.03780110061008PepBankPUB-03489472

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In C3H mice depressed by head and neck irradiation, optimal doses of thymosin alpha‑1 significantly increased delayed-type hypersensitivity.
In plain wordsIn irradiated mice, thymosin alpha‑1 improved a weakened delayed-type immune response.
Peptide
Thymosin alpha-1
Outcome
IncreaseDelayed-type hypersensitivity after head and neck irradiation
Study
mousen: not reported in source
C3H mice with head and neck irradiation (12 Gy)
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Mice receiving 1200 rad (12 Gy) of head and neck irradiation showed significant depression of delayed-type hypersensitivity, peripheral blood lymphocyte counts, spleen cell counts, and spleen cell production of interleukin-2.
2 context sentences(design, population, supporting numbers)
Summary · context
Treatment with optimal dosages of thymosin alpha 1 (T alpha-1) produced significant increases in all of these values, in some instances to levels higher than in the nonirradiated controls.
Summary · context
A model was developed in C3H mice to investigate the immunosuppressive effects of head and neck irradiation and to explore mechanisms for repair of the defects.
Report a problemFND-0348947201
02AnimalAnimal study (in vivo)Efficacy outcome
In C3H mice depressed by head and neck irradiation, optimal doses of thymosin alpha‑1 significantly increased peripheral blood lymphocyte counts.
In plain wordsIn irradiated mice, thymosin alpha‑1 raised lowered blood lymphocyte counts.
Peptide
Thymosin alpha-1
Outcome
IncreasePeripheral blood lymphocyte counts after head and neck irradiation
Study
mousen: not reported in source
C3H mice with head and neck irradiation (12 Gy)
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Mice receiving 1200 rad (12 Gy) of head and neck irradiation showed significant depression of delayed-type hypersensitivity, peripheral blood lymphocyte counts, spleen cell counts, and spleen cell production of interleukin-2.
2 context sentences(design, population, supporting numbers)
Summary · context
Treatment with optimal dosages of thymosin alpha 1 (T alpha-1) produced significant increases in all of these values, in some instances to levels higher than in the nonirradiated controls.
Summary · context
A model was developed in C3H mice to investigate the immunosuppressive effects of head and neck irradiation and to explore mechanisms for repair of the defects.
Report a problemFND-0348947202
03AnimalAnimal study (in vivo)Efficacy outcome
In C3H mice depressed by head and neck irradiation, optimal doses of thymosin alpha‑1 significantly increased spleen cell counts.
In plain wordsIn irradiated mice, thymosin alpha‑1 raised lowered spleen cell counts.
Peptide
Thymosin alpha-1
Outcome
IncreaseSpleen cell counts after head and neck irradiation
Study
mousen: not reported in source
C3H mice with head and neck irradiation (12 Gy)
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Mice receiving 1200 rad (12 Gy) of head and neck irradiation showed significant depression of delayed-type hypersensitivity, peripheral blood lymphocyte counts, spleen cell counts, and spleen cell production of interleukin-2.
2 context sentences(design, population, supporting numbers)
Summary · context
Treatment with optimal dosages of thymosin alpha 1 (T alpha-1) produced significant increases in all of these values, in some instances to levels higher than in the nonirradiated controls.
Summary · context
A model was developed in C3H mice to investigate the immunosuppressive effects of head and neck irradiation and to explore mechanisms for repair of the defects.
Report a problemFND-0348947203
04AnimalAnimal study (in vivo)Efficacy outcome
In C3H mice depressed by head and neck irradiation, optimal doses of thymosin alpha‑1 significantly increased spleen cell production of interleukin-2.
In plain wordsIn irradiated mice, thymosin alpha‑1 raised lowered interleukin-2 production by spleen cells.
Peptide
Thymosin alpha-1
Outcome
IncreaseSpleen cell interleukin-2 production after head and neck irradiation
Study
mousen: not reported in source
C3H mice with head and neck irradiation (12 Gy)
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Mice receiving 1200 rad (12 Gy) of head and neck irradiation showed significant depression of delayed-type hypersensitivity, peripheral blood lymphocyte counts, spleen cell counts, and spleen cell production of interleukin-2.
2 context sentences(design, population, supporting numbers)
Summary · context
Treatment with optimal dosages of thymosin alpha 1 (T alpha-1) produced significant increases in all of these values, in some instances to levels higher than in the nonirradiated controls.
Summary · context
A model was developed in C3H mice to investigate the immunosuppressive effects of head and neck irradiation and to explore mechanisms for repair of the defects.
Report a problemFND-0348947204
05AnimalAnimal study (in vivo)Efficacy outcome
In mice irradiated to a portal limited to the pelvic region, thymosin alpha‑1 induced only partial remission of the abnormalities.
In plain wordsIn mice irradiated only in the pelvic region, thymosin alpha‑1 partly reversed the immune abnormalities.
Peptide
Thymosin alpha-1
Outcome
MixedImmune abnormalities after pelvic irradiation
Study
mousen: not reported in source
C3H mice with pelvic-region irradiation
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
In identical experiments with mice irradiated to a portal limited to the pelvic region, T alpha-1 induced only partial remission of the abnormalities.
Report a problemFND-0348947205
06AnimalAnimal study (in vivo)Other
In mice with head and neck irradiation, the dose response of thymosin alpha‑1 showed a relatively limited dose range for immune restoration.
In plain wordsIn irradiated mice, thymosin alpha‑1 restored immune function only within a fairly narrow dose range.
Peptide
Thymosin alpha-1
Outcome
Not applicableDose range for immune restoration
Study
mousen: not reported in source
C3H mice with head and neck irradiation (12 Gy)
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
The dose response of T alpha-1 with head and neck irradiation showed a relatively limited dose range for immune restoration
1 context sentence(design, population, supporting numbers)
Summary · context
A model was developed in C3H mice to investigate the immunosuppressive effects of head and neck irradiation and to explore mechanisms for repair of the defects.
Report a problemFND-0348947206

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
10 Oct 2026, 08:55 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 03:02 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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