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Study · Ex vivo tissue · mouse · 1986

4 results

In vitro effect of thymosin alpha 1 on the expression of peanut agglutinin binding by murine thymocytes.

Rinaldi-Garaci C, Baldassarre AM, Pesce A, Frati L, Lazdins JK

Cellular immunology1 Aug 1986Cited by 1 (Europe PMC)

PMID3488822 (opens in a new tab)DOI10.1016/0008-8749(86)90181-4 (opens in a new tab)PepBankPUB-03488822
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In vitro, thymosin alpha‑1 induced loss of PNA binding ability in a subpopulation of murine thymocytes.

    In plain wordsIn mouse thymus cells in lab tests, thymosin alpha‑1 caused some cells to lose their ability to bind peanut agglutinin.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreasePeanut agglutinin (PNA) binding by thymocytes
    Study

    mousen: not reported in source

    Murine thymocytes in vitro
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymosin alpha 1 induces the loss of PNA binding ability by subpopulation of thymic cells.
  2. 02LabEx vivo tissueMechanism

    The loss of PNA binding after thymosin alpha‑1 was not permanent, suggesting recycling of the PNA binding molecule.

    In plain wordsIn mouse thymus cells in lab tests, the loss of peanut agglutinin binding after thymosin alpha‑1 was temporary.

    Peptide
    Thymosin alpha-1
    Outcome
    MixedRecovery of PNA binding after thymosin alpha 1
    Study

    mousen: not reported in source

    Murine thymocytes in vitro
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Nevertheless this disappearance is not a permanent one, suggesting a recycling of the PNA binding molecule.
  3. 03LabEx vivo tissueMechanism

    Only a small proportion of the total PNA+ thymocytes modulated their PNA binding sites after exposure to thymosin alpha‑1.

    In plain wordsIn mouse thymus cells in lab tests, only a small share of cells responded to thymosin alpha‑1.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableProportion of PNA+ thymocytes susceptible to thymosin alpha 1
    Study

    mousen: not reported in source

    Murine thymocytes in vitro
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The cells that modulate their PNA binding sites after exposure to Thymosin alpha 1 are a small proportion of the total PNA+ thymocytes, indicating that not all thymocytes are susceptible to the thymic hormone Thymosin alpha 1.
  4. 04LabEx vivo tissueMechanism

    Exposure of thymocytes to thymosin alpha‑1 induced disappearance of the binding sites for this ligand without further recycling.

    In plain wordsIn mouse thymus cells in lab tests, thymosin alpha‑1 exposure made its own binding sites disappear without return.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseThymosin alpha 1 binding sites on thymocytes
    Study

    mousen: not reported in source

    Murine thymocytes in vitro
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Conversely the exposure of thymocytes to Thymosin alpha 1 induces the disappearance of the binding sites for this ligand without further recycling, behavior expected for the receptor of a regulatory ligand.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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