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Study · Animal study (in vivo) · sheep and goats · 1986

2 results

Control of binucleate cell migration in the placenta of sheep and goats.

Wooding FB, Flint AP, Heap RB, Morgan G, Buttle HL, Young IR

Journal of reproduction and fertility1 Mar 1986Cited by 39 (Europe PMC)

PMID3486281 (opens in a new tab)DOI10.1530/jrf.0.0760499 (opens in a new tab)PepBankPUB-03486281
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In intact or hypophysectomized ruminant fetuses, tetracosactrin induced an early fall in placental binucleate cell numbers.

    In plain wordsIn sheep and goats, tetracosactrin caused an early decrease in placental binucleate cell numbers.

    Peptide
    Cosyntropin
    Outcome
    DecreasePlacental binucleate cell numbers
    Study

    sheep and goatsn: not reported in source

    Ruminant placenta
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    BNC numbers decrease normally just before parturition, and this fall could be eliminated by fetal hypophysectomy or induced early by administration of tetracosactrin to intact or hypophysectomized fetuses.
    1 context sentence
    Summary · context
    The number of BNC, their percentage migration and the potential secretory activity of the syncytium they form were estimated by semiquantitative transmission electron-microscopical techniques after several surgical techniques and hormone or drug infusions.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In ruminant twins, placental binucleate cell numbers fell with tetracosactrin treatment but not in untreated twins unless they died before sampling.

    In plain wordsIn sheep and goats, cell numbers fell in tetracosactrin-treated twins, but not untreated twins unless they died before sampling.

    Peptide
    Cosyntropin
    Outcome
    DecreasePlacental binucleate cell numbers in treated twins
    Study

    sheep and goatsn: not reported in source

    Ruminant placenta
    Comparator
    Untreated twin
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    If only one twin was treated with tetracosactrin the placenta of the untreated twin did not show the fall in BNC numbers found in the other unless it died in utero some time before sampling.
    1 context sentence
    Summary · context
    The number of BNC, their percentage migration and the potential secretory activity of the syncytium they form were estimated by semiquantitative transmission electron-microscopical techniques after several surgical techniques and hormone or drug infusions.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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