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Study · Ex vivo tissue · guinea pig and rat · 1987

5 results

Neurons in the dorsal motor nucleus of the vagus nerve are excited by oxytocin in the rat but not in the guinea pig.

Raggenbass M, Dubois-Dauphin M, Charpak S, Dreifuss JJ

Proceedings of the National Academy of Sciences of the United States of America1 Jun 1987Cited by 43 (Europe PMC)

PMID3473490 (opens in a new tab)PMCIDPMC304989 (opens in a new tab)DOI10.1073/pnas.84.11.3926 (opens in a new tab)PepBankPUB-03473490
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In rat brainstem slices, oxytocin at 10-1000 nM increased the firing rate of virtually all neurons in the dorsal motor nucleus of the vagus nerve.

    In plain wordsIn rat brain slices, oxytocin made nearly all neurons in the vagus nerve's motor nucleus fire faster.

    Peptide
    Oxytocin
    Outcome
    IncreaseVagal neuron firing rate (rat)
    Study

    ratn: not reported in source

    Brainstem slices, dorsal motor nucleus of the vagus
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    10-1000 nMAs given in this study (rat).

    Source sentences

    Summary
    In the rat, virtually all neurons throughout the rostrocaudal extent of the dmnX increased their rate of firing in the presence of 10-1000 nM oxytocin and their membrane depolarized in a reversible concentration-dependent manner.
    1 context sentence
    Summary · context
    Intracellular recordings were obtained from vagal neurons and their response to oxytocin was investigated in slices from the rat and the guinea pig brainstem.
  2. 02LabEx vivo tissueActivity measurement

    In rat brainstem slices, oxytocin depolarized the membrane of dorsal motor nucleus neurons in a reversible, concentration-dependent manner.

    In plain wordsIn rat brain slices, oxytocin reversibly depolarized vagal neurons, and a higher concentration gave a larger effect.

    Peptide
    Oxytocin
    Outcome
    IncreaseVagal neuron membrane depolarization (rat)
    Study

    ratn: not reported in source

    Brainstem slices, dorsal motor nucleus of the vagus
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    10-1000 nMAs given in this study (rat).

    Source sentences

    Summary
    In the rat, virtually all neurons throughout the rostrocaudal extent of the dmnX increased their rate of firing in the presence of 10-1000 nM oxytocin and their membrane depolarized in a reversible concentration-dependent manner.
    1 context sentence
    Summary · context
    Intracellular recordings were obtained from vagal neurons and their response to oxytocin was investigated in slices from the rat and the guinea pig brainstem.
  3. 03LabEx vivo tissueMechanism

    In rat brainstem slices, the oxytocin excitation of vagal neurons persisted in low calcium/high magnesium medium or with tetrodotoxin, which suggests a direct action on the recorded cells.

    In plain wordsIn rat brain slices, oxytocin still excited vagal neurons when synaptic signalling was blocked, so it probably acts directly on them.

    Peptide
    Oxytocin
    Outcome
    IncreasePersistence of excitation under synaptic blockade
    Study

    ratn: not reported in source

    Brainstem slices, dorsal motor nucleus of the vagus
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This excitation was probably exerted directly on the impaled cells rather than being synaptically mediated, since it persisted in a low calcium/high magnesium medium or in the presence of tetrodotoxin.
    1 context sentence
    Summary · context
    Intracellular recordings were obtained from vagal neurons and their response to oxytocin was investigated in slices from the rat and the guinea pig brainstem.
  4. 04LabEx vivo tissueActivity measurement

    In guinea pig brainstem slices, vagal neurons were excited by glutamate but not by oxytocin.

    In plain wordsIn guinea pig brain slices, oxytocin did not excite vagal neurons, although glutamate did.

    Peptide
    Oxytocin
    Outcome
    No significant changeVagal neuron excitation (guinea pig)
    Study

    guinea pign: not reported in source

    Brainstem slices, dorsal motor nucleus of the vagus
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the guinea pig, vagal neurons were fired by glutamate but were not excited by oxytocin
    1 context sentence
    Summary · context
    Intracellular recordings were obtained from vagal neurons and their response to oxytocin was investigated in slices from the rat and the guinea pig brainstem.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 05LabEndogenous levelEx vivo tissueOther

    The guinea pig dorsal motor nucleus of the vagus nerve contained many more oxytocin-immunoreactive structures than the rat nucleus.

    In plain wordsGuinea pig brain tissue held more of the body's own oxytocin-containing structures in this nucleus than rat tissue.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin-immunoreactive structures in dmnX
    Study

    guinea pign: not reported in source

    Brainstem slices, dorsal motor nucleus of the vagus
    Comparator
    Rat
    Outcome group
    Brain and neuronal activity · Nervous system and cognition

    Source sentences

    Summary
    we detected many more oxytocin-immunoreactive structures in the guinea pig dmnX than in the rat dmnX.
    1 context sentence
    Summary · context
    Intracellular recordings were obtained from vagal neurons and their response to oxytocin was investigated in slices from the rat and the guinea pig brainstem.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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