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Study · In vitro (cells) · chick and rat · 1987

4 results

A comparative study of disaggregated chick and rat osteoclasts in vitro: effects of calcitonin and prostaglandins.

Arnett TR, Dempster DW

Endocrinology1 Feb 1987Cited by 133 (Europe PMC)

PMID3467966 (opens in a new tab)DOI10.1210/endo-120-2-602 (opens in a new tab)PepBankPUB-03467966
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In cultured rat osteoclasts, synthetic salmon calcitonin completely abolished bone resorption at 10 pg/ml.

    In plain wordsIn lab tests, salmon calcitonin completely stopped bone resorption by rat osteoclasts at 10 pg/ml.

    Peptide
    Calcitonin-salmon
    Outcome
    DecreaseBone resorption by rat osteoclasts
    Study

    ratn: not reported in source

    Disaggregated osteoclasts on bovine cortical bone slices
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 pg/mlAs given in this study (rat).

    Source sentences

    Summary
    Bone resorption by rat osteoclasts was completely abolished by synthetic sCT at a concentration of 10 pg/ml.
    1 context sentence
    Summary · context
    Disaggregated chick osteoclasts sedimented onto bovine cortical bone slices excavate deep and sharply defined resorption lacunae that stain intensely with toluidine blue.
  2. 02LabIn vitro (cells)Activity measurement

    In cultured chick osteoclasts, salmon calcitonin up to 100 micrograms/ml did not significantly inhibit bone resorption.

    In plain wordsIn lab tests, salmon calcitonin up to 100 micrograms/ml did not significantly inhibit bone resorption by chick osteoclasts.

    Peptide
    Calcitonin-salmon
    Outcome
    No significant changeBone resorption by chick osteoclasts
    Study

    chickn: not reported in source

    Disaggregated osteoclasts on bovine cortical bone slices
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    up to 100 micrograms/mlAs given in this study (chick).

    Source sentences

    Summary
    In contrast, sCT at concentrations up to 100 micrograms/ml did not significantly inhibit bone resorption by chick osteoclasts.
    1 context sentence
    Summary · context
    Disaggregated chick osteoclasts sedimented onto bovine cortical bone slices excavate deep and sharply defined resorption lacunae that stain intensely with toluidine blue.
  3. 03LabIn vitro (cells)Activity measurement

    In cultured rat osteoclasts, salmon calcitonin at 5-50 pg/ml rapidly inhibited motility.

    In plain wordsIn lab tests, salmon calcitonin at 5-50 pg/ml rapidly inhibited rat osteoclast movement.

    Peptide
    Calcitonin-salmon
    Outcome
    DecreaseRat osteoclast motility
    Study

    ratn: not reported in source

    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    5-50 pg/mlAs given in this study (rat).

    Source sentences

    Summary
    In time-lapse video experiments, the motility of rat osteoclasts was rapidly inhibited by sCT (5-50 pg/ml), prostaglandins I2 and E2 (less than or equal to 10(-4) M), and Bu2cAMP (2.5 X 10(-4) M), whereas chick osteoclasts failed to show such a response.
  4. 04LabIn vitro (cells)Activity measurement

    In cultured chick osteoclasts, salmon calcitonin did not produce the motility inhibition observed in rat osteoclasts.

    In plain wordsIn lab tests, chick osteoclasts did not show the movement inhibition seen in rat osteoclasts with salmon calcitonin.

    Peptide
    Calcitonin-salmon
    Outcome
    Direction not reportedChick osteoclast motility
    Study

    chickn: not reported in source

    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In time-lapse video experiments, the motility of rat osteoclasts was rapidly inhibited by sCT (5-50 pg/ml), prostaglandins I2 and E2 (less than or equal to 10(-4) M), and Bu2cAMP (2.5 X 10(-4) M), whereas chick osteoclasts failed to show such a response.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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