Interacting sleep-modulatory effects of simultaneously administered delta-sleep-inducing peptide, muramyl dipeptide and uridine in unrestrained rats.

Kimura M, Honda K, Komoda Y, Inoué S

Neuroscience research1 Dec 1987Cited by 4 (Europe PMC)

PMID3431755DOI10.1016/0168-0102(87)90031-9PepBankPUB-03431755

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone6

In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Delta sleep-inducing peptide (DSIP).

01AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome
In unrestrained rats, an intracerebroventricular infusion of DSIP combined with muramyl dipeptide produced a profound increase in slow-wave sleep only at the middle infusion period.
In plain wordsIn rats, DSIP given together with muramyl dipeptide increased deep sleep, but only in the middle of the infusion.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseSlow-wave sleep (SWS) with DSIP-MDP combination
Study
ratn: not reported in source
Outcome group
Sleep · Sleep
Source sentences
Summary
The DSIP-MDP combination was characterized by a profound increase in SWS only at the middle infusion period.
1 context sentence(design, population, supporting numbers)
Summary · context
A 10-h nocturnal intracerebroventricular infusion of 2 or 3 sleep substances such as 2.5 nmol delta-sleep-inducing peptide (DSIP), 2.0 nmol muramyl dipeptide (MDP) and 10 pmol uridine
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).
Report a problemFND-0343175501
02AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome
In unrestrained rats, paradoxical sleep was little affected by the DSIP and muramyl dipeptide combination.
In plain wordsIn rats, DSIP given together with muramyl dipeptide had little effect on paradoxical (REM-type) sleep.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeParadoxical sleep (PS) with DSIP-MDP combination
Study
ratn: not reported in source
Outcome group
Sleep · Sleep
Source sentences
Summary
PS was little affected.
1 context sentence(design, population, supporting numbers)
Summary · context
A 10-h nocturnal intracerebroventricular infusion of 2 or 3 sleep substances such as 2.5 nmol delta-sleep-inducing peptide (DSIP), 2.0 nmol muramyl dipeptide (MDP) and 10 pmol uridine
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).
Report a problemFND-0343175502
03AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome
In unrestrained rats, the DSIP and uridine combination slightly increased slow-wave sleep at the late infusion period.
In plain wordsIn rats, DSIP given together with uridine slightly increased deep sleep late in the infusion.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseSlow-wave sleep (SWS) with DSIP-uridine combination
Study
ratn: not reported in source
Outcome group
Sleep · Sleep
Source sentences
Summary
The DSIP-uridine combination exerted a slight increase in SWS at the late infusion period with little change in PS parameters.
1 context sentence(design, population, supporting numbers)
Summary · context
A 10-h nocturnal intracerebroventricular infusion of 2 or 3 sleep substances such as 2.5 nmol delta-sleep-inducing peptide (DSIP), 2.0 nmol muramyl dipeptide (MDP) and 10 pmol uridine
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).
Report a problemFND-0343175503
04AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome
In unrestrained rats, the DSIP and uridine combination caused little change in paradoxical sleep parameters.
In plain wordsIn rats, DSIP given together with uridine caused little change in paradoxical (REM-type) sleep.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeParadoxical sleep (PS) with DSIP-uridine combination
Study
ratn: not reported in source
Outcome group
Sleep · Sleep
Source sentences
Summary
The DSIP-uridine combination exerted a slight increase in SWS at the late infusion period with little change in PS parameters.
1 context sentence(design, population, supporting numbers)
Summary · context
A 10-h nocturnal intracerebroventricular infusion of 2 or 3 sleep substances such as 2.5 nmol delta-sleep-inducing peptide (DSIP), 2.0 nmol muramyl dipeptide (MDP) and 10 pmol uridine
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).
Report a problemFND-0343175504
05AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome
In unrestrained rats, the three-substance combination of DSIP, muramyl dipeptide and uridine induced an extremely large increase in slow-wave sleep at the early to middle phase of the infusion.
In plain wordsIn rats, DSIP with muramyl dipeptide and uridine together caused a very large increase in deep sleep early in the infusion.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseSlow-wave sleep (SWS) with DSIP-MDP-uridine combination
Study
ratn: not reported in source
Outcome group
Sleep · Sleep
Source sentences
Summary
The DSIP-MDP-uridine combination induced an extremely large increase in SWS at the early to middle phase of the infusion period.
1 context sentence(design, population, supporting numbers)
Summary · context
A 10-h nocturnal intracerebroventricular infusion of 2 or 3 sleep substances such as 2.5 nmol delta-sleep-inducing peptide (DSIP), 2.0 nmol muramyl dipeptide (MDP) and 10 pmol uridine
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).
Report a problemFND-0343175505
06AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome
In unrestrained rats, paradoxical sleep increased significantly with the three-substance combination of DSIP, muramyl dipeptide and uridine, only at the early phase.
In plain wordsIn rats, DSIP with muramyl dipeptide and uridine together raised paradoxical (REM-type) sleep, but only early in the infusion.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseParadoxical sleep (PS) with DSIP-MDP-uridine combination
Study
ratn: not reported in source
Outcome group
Sleep · Sleep
Source sentences
Summary
PS significantly increased only at the early phase.
1 context sentence(design, population, supporting numbers)
Summary · context
A 10-h nocturnal intracerebroventricular infusion of 2 or 3 sleep substances such as 2.5 nmol delta-sleep-inducing peptide (DSIP), 2.0 nmol muramyl dipeptide (MDP) and 10 pmol uridine
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).
Report a problemFND-0343175506

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.