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Study · Animal study (in vivo) · rat · 1987

12 results

Immune-neuroendocrine interactions during aging: age-dependent thyrotropin-inhibiting activity of thymosin peptides.

Goya RG, Takahashi S, Quigley KL, Sosa YE, Goldstein AL, Meites J

Mechanisms of ageing and development1 Dec 1987Cited by 13 (Europe PMC)

PMID3431174 (opens in a new tab)DOI10.1016/0047-6374(87)90042-x (opens in a new tab)PepBankPUB-03431174
Publisher pagePubMedAsk about this study
Jump to 12 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, injected synthetic thymosin alpha‑1 at doses up to 5 µg/kg body weight had no effect on the hormones measured in the study (TSH, T4, T3, corticosterone and prolactin).

    In plain wordsIn rats, synthetic thymosin alpha‑1 did not change thyroid, stress or prolactin hormone levels at doses up to 5 micrograms per kilogram.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changePlasma TSH, T4, T3, corticosterone and prolactin after synthetic thymosin alpha-1
    Study

    ratn: not reported in source

    Sprague-Dawley male rats
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    up to 5 µg/kg body weightAs given in this study (rat).

    Source sentences

    Summary
    The synthetic peptides thymosin alpha-1 and serum thymic factor, which are components of TF-5, had no effect on the above hormones when injected in doses up to 5 micrograms/kg body wt.
    1 context sentence
    Summary · context
    We report here the effect of TF-5 on the TSH-thyroid axis in young (3 months) and old (25 months) Sprague-Dawley male rats.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, synthetic serum thymic factor did not affect TSH at doses up to 5 micrograms/kg.

    In plain wordsIn rats, synthetic thymulin did not change TSH at the tested doses.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeTSH after serum thymic factor
    Study

    ratn: not reported in source

    Sprague-Dawley male rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    up to 5 micrograms/kg body wt. · injectionAs given in this study (rat).

    Source sentences

    Summary
    The synthetic peptides thymosin alpha-1 and serum thymic factor, which are components of TF-5, had no effect on the above hormones when injected in doses up to 5 micrograms/kg body wt.
    1 context sentence
    Summary · context
    In the young rats, TF-5 induced a marked reduction of plasma thyrotropin (TSH) which was significantly greater than the normal circadian decline observed in the BSA-treated controls.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, synthetic serum thymic factor did not affect thyroxine at doses up to 5 micrograms/kg.

    In plain wordsIn rats, synthetic thymulin did not change thyroxine at the tested doses.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeThyroxine after serum thymic factor
    Study

    ratn: not reported in source

    Sprague-Dawley male rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    up to 5 micrograms/kg body wt. · injectionAs given in this study (rat).

    Source sentences

    Summary
    The synthetic peptides thymosin alpha-1 and serum thymic factor, which are components of TF-5, had no effect on the above hormones when injected in doses up to 5 micrograms/kg body wt.
    1 context sentence
    Summary · context
    Thyroxine (T4), triiodothyronine (T3), corticosterone, and prolactin levels were not affected by TF-5 at the dose levels tested.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats, synthetic serum thymic factor did not affect triiodothyronine at doses up to 5 micrograms/kg.

    In plain wordsIn rats, synthetic thymulin did not change triiodothyronine at the tested doses.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeTriiodothyronine after serum thymic factor
    Study

    ratn: not reported in source

    Sprague-Dawley male rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    up to 5 micrograms/kg body wt. · injectionAs given in this study (rat).

    Source sentences

    Summary
    The synthetic peptides thymosin alpha-1 and serum thymic factor, which are components of TF-5, had no effect on the above hormones when injected in doses up to 5 micrograms/kg body wt.
    1 context sentence
    Summary · context
    Thyroxine (T4), triiodothyronine (T3), corticosterone, and prolactin levels were not affected by TF-5 at the dose levels tested.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats, synthetic serum thymic factor did not affect corticosterone at doses up to 5 micrograms/kg.

    In plain wordsIn rats, synthetic thymulin did not change corticosterone at the tested doses.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeCorticosterone after serum thymic factor
    Study

    ratn: not reported in source

    Sprague-Dawley male rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    up to 5 micrograms/kg body wt. · injectionAs given in this study (rat).

    Source sentences

    Summary
    The synthetic peptides thymosin alpha-1 and serum thymic factor, which are components of TF-5, had no effect on the above hormones when injected in doses up to 5 micrograms/kg body wt.
    1 context sentence
    Summary · context
    Thyroxine (T4), triiodothyronine (T3), corticosterone, and prolactin levels were not affected by TF-5 at the dose levels tested.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats, synthetic serum thymic factor did not affect prolactin at doses up to 5 micrograms/kg.

    In plain wordsIn rats, synthetic thymulin did not change prolactin at the tested doses.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeProlactin after serum thymic factor
    Study

    ratn: not reported in source

    Sprague-Dawley male rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    up to 5 micrograms/kg body wt. · injectionAs given in this study (rat).

    Source sentences

    Summary
    The synthetic peptides thymosin alpha-1 and serum thymic factor, which are components of TF-5, had no effect on the above hormones when injected in doses up to 5 micrograms/kg body wt.
    1 context sentence
    Summary · context
    Thyroxine (T4), triiodothyronine (T3), corticosterone, and prolactin levels were not affected by TF-5 at the dose levels tested.

Studies that did not test the peptide alone6

In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymulin (serum thymic factor).

  1. 07AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism

    In young rats, TF-5 reduced plasma TSH more than the circadian decline in BSA-treated controls.

    In plain wordsIn young rats, the mixed TF-5 preparation reduced TSH more than the normal decline in BSA-treated controls.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseTSH in young rats after TF-5
    Study

    ratn: not reported in source

    Sprague-Dawley male rats
    Comparator
    BSA-treated controls
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    In the young rats, TF-5 induced a marked reduction of plasma thyrotropin (TSH) which was significantly greater than the normal circadian decline observed in the BSA-treated controls.
    1 context sentence
    Summary · context
    The synthetic peptides thymosin alpha-1 and serum thymic factor, which are components of TF-5, had no effect on the above hormones when injected in doses up to 5 micrograms/kg body wt.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  2. 08AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism

    In old rats, TSH did not respond to TF-5.

    In plain wordsIn old rats, the mixed TF-5 preparation did not change TSH.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeTSH in old rats after TF-5
    Study

    ratn: not reported in source

    Sprague-Dawley male rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    The old males displayed high basal levels of TSH which showed no circadian rhythmicity, and did not respond to TF-5.
    1 context sentence
    Summary · context
    The synthetic peptides thymosin alpha-1 and serum thymic factor, which are components of TF-5, had no effect on the above hormones when injected in doses up to 5 micrograms/kg body wt.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  3. 09AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism

    In rats, TF-5 did not affect thyroxine levels at the tested doses.

    In plain wordsIn rats, the mixed TF-5 preparation did not change thyroxine levels at the tested doses.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeThyroxine after TF-5
    Study

    ratn: not reported in source

    Sprague-Dawley male rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Thyroxine (T4), triiodothyronine (T3), corticosterone, and prolactin levels were not affected by TF-5 at the dose levels tested.
    1 context sentence
    Summary · context
    The synthetic peptides thymosin alpha-1 and serum thymic factor, which are components of TF-5, had no effect on the above hormones when injected in doses up to 5 micrograms/kg body wt.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  4. 10AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism

    In rats, TF-5 did not affect triiodothyronine levels at the tested doses.

    In plain wordsIn rats, the mixed TF-5 preparation did not change triiodothyronine levels at the tested doses.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeTriiodothyronine after TF-5
    Study

    ratn: not reported in source

    Sprague-Dawley male rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Thyroxine (T4), triiodothyronine (T3), corticosterone, and prolactin levels were not affected by TF-5 at the dose levels tested.
    1 context sentence
    Summary · context
    The synthetic peptides thymosin alpha-1 and serum thymic factor, which are components of TF-5, had no effect on the above hormones when injected in doses up to 5 micrograms/kg body wt.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  5. 11AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism

    In rats, TF-5 did not affect corticosterone levels at the tested doses.

    In plain wordsIn rats, the mixed TF-5 preparation did not change corticosterone levels at the tested doses.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeCorticosterone after TF-5
    Study

    ratn: not reported in source

    Sprague-Dawley male rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Thyroxine (T4), triiodothyronine (T3), corticosterone, and prolactin levels were not affected by TF-5 at the dose levels tested.
    1 context sentence
    Summary · context
    The synthetic peptides thymosin alpha-1 and serum thymic factor, which are components of TF-5, had no effect on the above hormones when injected in doses up to 5 micrograms/kg body wt.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  6. 12AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism

    In rats, TF-5 did not affect prolactin levels at the tested doses.

    In plain wordsIn rats, the mixed TF-5 preparation did not change prolactin levels at the tested doses.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeProlactin after TF-5
    Study

    ratn: not reported in source

    Sprague-Dawley male rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Thyroxine (T4), triiodothyronine (T3), corticosterone, and prolactin levels were not affected by TF-5 at the dose levels tested.
    1 context sentence
    Summary · context
    The synthetic peptides thymosin alpha-1 and serum thymic factor, which are components of TF-5, had no effect on the above hormones when injected in doses up to 5 micrograms/kg body wt.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 5 to 13Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 9 times, first on 21 Oct 2026, 15:59 UTC. The status did not change between them.

    Study results updated

  2. Version 4

    21 Oct 2026, 12:50 UTC

    Study data updated · source update from Europe PMC

  3. Version 3

    10 Oct 2026, 08:55 UTC

    Study results updated

  4. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  5. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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