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Study · Animal study (in vivo) · rabbit and sheep · 1988

3 results

Passage of delta sleep-inducing peptide (DSIP) across the blood-cerebrospinal fluid barrier.

Zlokovic BV, Segal MB, Davson H, Jankov RM

Peptides1 May 1988Cited by 15 (Europe PMC)

PMID3420012 (opens in a new tab)DOI10.1016/0196-9781(88)90160-x (opens in a new tab)PepBankPUB-03420012
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In perfused sheep choroid plexus, arterio-venous loss of 125I radioactivity suggested low-to-moderate permeability of the choroid epithelium to intact DSIP from the blood side.

    In plain wordsIn sheep, DSIP crossed the choroid plexus barrier from blood at a low-to-moderate rate.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableChoroid epithelium permeability to intact DSIP
    Study

    sheepn: not reported in source

    Perfused in situ choroid plexus of lateral ventricles
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · perfusionAs given in this study (sheep).

    Source sentences

    Summary
    Arterio-venous loss of 125I-radioactivity suggested a low-to-moderate permeability of the choroid epithelium to the intact peptide from the blood side.
    1 context sentence
    Summary · context
    Unidirectional flux of 125I-labeled DSIP at the blood-tissue interface of the blood-cerebrospinal fluid (CSF) barrier was studied in the perfused in situ choroid plexuses of the lateral ventricles of the sheep.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In perfused sheep choroid plexus, a saturable, high-affinity, very low-capacity Michaelis-Menten transport of DSIP was shown at the blood-tissue interface.

    In plain wordsIn sheep, a saturable transport system moved DSIP across the choroid plexus, with high affinity but very low capacity.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableSaturable DSIP transport kinetics
    Study

    sheepn: not reported in source

    Perfused in situ choroid plexus of lateral ventricles
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · perfusionAs given in this study (sheep).

    Measurements

    Kt
    5 nM
    sheep choroid plexus blood-tissue interface
    Vmax
    272 fmol.min-1
    sheep choroid plexus blood-tissue interface

    Source sentences

    Summary
    A saturable mechanism with Michaelis-Menten type kinetics with high affinity and very low capacity (approximate values: Kt = 5.0 +/- 0.4 nM; Vmax = 272 +/- 10 fmol.min-1) was demonstrated at the blood-tissue interface of the choroid plexus.
    1 context sentence
    Summary · context
    Unidirectional flux of 125I-labeled DSIP at the blood-tissue interface of the blood-cerebrospinal fluid (CSF) barrier was studied in the perfused in situ choroid plexuses of the lateral ventricles of the sheep.
  3. 03AnimalAnimal study (in vivo)Pharmacokinetics

    In rabbits, ventriculo-cisternal perfusion showed no significant flux of intact DSIP out of the cerebrospinal fluid.

    In plain wordsIn rabbits, intact DSIP was not removed from the cerebrospinal fluid in any significant amount.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeClearance of DSIP out of the CSF
    Study

    rabbitn: not reported in source

    Ventriculo-cisternal perfusion
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · perfusionAs given in this study (rabbit).

    Source sentences

    Summary
    The clearance of DSIP from the ventricles during ventriculo-cisternal perfusion in the rabbit indicated no significant flux of the intact peptide out of the CSF.
    1 context sentence
    Summary · context
    Unidirectional flux of 125I-labeled DSIP at the blood-tissue interface of the blood-cerebrospinal fluid (CSF) barrier was studied in the perfused in situ choroid plexuses of the lateral ventricles of the sheep.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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