Gonadotropin therapy in men with isolated hypogonadotropic hypogonadism: the response to human chorionic gonadotropin is predicted by initial testicular size.

Burris AS, Rodbard HW, Winters SJ, Sherins RJ

The Journal of clinical endocrinology and metabolism1 Jun 1988Cited by 112 (Europe PMC)

PMID3372679DOI10.1210/jcem-66-6-1144PepBankPUB-03372679

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. 11 results from people.

01HumanNon-randomized trialEfficacy outcome
In men with isolated hypogonadotropic hypogonadism, hCG increased mean testicular volume from 5.5 to 10.8 mL.
In plain wordsIn men with hypogonadotropic hypogonadism, hCG increased testicular volume compared with pretreatment.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseTesticular volume
Study
n = 22
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Measurements
Testicular volume, pretreatment
5.5 mL
22 men, mean (SE 1.1)
Testicular volume, maximum during treatment
10.8 mL
22 men, mean (SE 1.6)
Source sentences
Summary
Their mean testicular volume increased from 5.5 +/- 1.1 (+/- SE) mL (pretreatment) to 10.8 +/- 1.6 mL (maximum) during treatment (P less than 10(-6)).
1 context sentence(design, population, supporting numbers)
Summary · context
This study was designed to determine whether exogenous hCG alone can complete spermiogenesis in men with isolated hypogonadotropic hypogonadism (IHH). hCG was administered to 22 men with IHH until maximal testicular growth was achieved.
Report a problemFND-0337267901
02HumanNon-randomized trialOther
In men receiving hCG for isolated hypogonadotropic hypogonadism, maximum testicular volume correlated positively with initial volume.
In plain wordsIn men receiving hCG, larger initial testes were linked to larger maximum testicular volume.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseMaximum volume and initial volume
Study
n = 22
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Measurements
Correlation of maximum testicular volume with initial volume (r)
0.84 r
22 men
Source sentences
Summary
The maximum mean testicular volume was highly positively correlated with initial volume (r = 0.84; P less than 10(-6)).
1 context sentence(design, population, supporting numbers)
Summary · context
This study was designed to determine whether exogenous hCG alone can complete spermiogenesis in men with isolated hypogonadotropic hypogonadism (IHH). hCG was administered to 22 men with IHH until maximal testicular growth was achieved.
Report a problemFND-0337267902
03HumanNon-randomized trialEfficacy outcome
In men with isolated hypogonadotropic hypogonadism, all men attained normal serum testosterone during hCG treatment.
In plain wordsIn men with hypogonadotropic hypogonadism, all men attained normal testosterone during hCG treatment.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseTestosterone normalization
Study
n = 22
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
All men attained normal serum testosterone levels, and 7 of 22 men achieved supraphysiological serum estradiol levels.
1 context sentence(design, population, supporting numbers)
Summary · context
This study was designed to determine whether exogenous hCG alone can complete spermiogenesis in men with isolated hypogonadotropic hypogonadism (IHH). hCG was administered to 22 men with IHH until maximal testicular growth was achieved.
Report a problemFND-0337267903
04HumanNon-randomized trialSafety outcome
In men with isolated hypogonadotropic hypogonadism, 7 of 22 men attained supraphysiological serum estradiol during hCG treatment.
In plain wordsIn men with hypogonadotropic hypogonadism, 7 of 22 developed above-normal estradiol levels during hCG treatment.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseSupraphysiological estradiol
Study
n = 22
Outcome group
Adverse events · Reproductive and sexual health
Studied dose
Dose not stated
Measurements
Men with supraphysiological serum estradiol
7 men
of 22 men on hCG
Source sentences
Summary
All men attained normal serum testosterone levels, and 7 of 22 men achieved supraphysiological serum estradiol levels.
1 context sentence(design, population, supporting numbers)
Summary · context
This study was designed to determine whether exogenous hCG alone can complete spermiogenesis in men with isolated hypogonadotropic hypogonadism (IHH). hCG was administered to 22 men with IHH until maximal testicular growth was achieved.
Report a problemFND-0337267904
05HumanNon-randomized trialEfficacy outcome
In men with isolated hypogonadotropic hypogonadism, sperm appeared in semen in 14 of 22 men during hCG treatment.
In plain wordsIn men with hypogonadotropic hypogonadism, sperm appeared in semen in 14 of 22 men during hCG treatment.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseSperm appearance
Study
n = 22
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Measurements
Men with sperm in semen
14 men
of 22 men on hCG
Source sentences
Summary
During hCG treatment, 14 of the 22 men had sperm appear in their semen.
1 context sentence(design, population, supporting numbers)
Summary · context
This study was designed to determine whether exogenous hCG alone can complete spermiogenesis in men with isolated hypogonadotropic hypogonadism (IHH). hCG was administered to 22 men with IHH until maximal testicular growth was achieved.
Report a problemFND-0337267905
06HumanNon-randomized trialEfficacy outcome
In men receiving hCG, 9 of 11 with partial deficiency produced sperm, compared with six of 11 with complete deficiency.
In plain wordsIn men receiving hCG, sperm production occurred more often with partial than complete gonadotropin deficiency.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseSperm positivity in partial deficiency
Study
n = 22
Comparator
Complete gonadotropin deficiency
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Measurements
Men sperm positive
9 men
of 11 with partial gonadotropin deficiency
Men sperm positive
6 men
of 11 with complete gonadotropin deficiency
P value
< 0.001 p value
Sperm positivity in partial versus complete gonadotropin deficiency during hCG treatment
Source sentences
Summary
In contrast, 9 of 11 men with partial gonadotropin deficiency (initial mean testicular volume of 4 mL or more) produced sperm during treatment (P less than 0.001).
2 context sentences(design, population, supporting numbers)
Summary · context
Six of 11 men with complete gonadotropin deficiency, defined as an initial mean testicular volume less than 4 mL, became sperm positive during hCG treatment.
Summary · context
This study was designed to determine whether exogenous hCG alone can complete spermiogenesis in men with isolated hypogonadotropic hypogonadism (IHH). hCG was administered to 22 men with IHH until maximal testicular growth was achieved.
Report a problemFND-0337267907
07HumanNon-randomized trialEfficacy outcome
In men receiving hCG for isolated hypogonadotropic hypogonadism, 7 of 13 attempting conception succeeded, with 8 pregnancies.
In plain wordsIn men receiving hCG, 7 of 13 attempting conception succeeded, with 8 pregnancies.
Peptide
hCG (human chorionic gonadotropin)
Outcome
Not applicablePartner conception
Study
n = 13
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Measurements
Men initiating conception
7 men
of 13 attempting
Pregnancies
8 pregnancies
total
Source sentences
Summary
Of 13 men attempting to impregnate their partners, 7 were successful in initiating conception; a total of 8 pregnancies ensued.
1 context sentence(design, population, supporting numbers)
Summary · context
This study was designed to determine whether exogenous hCG alone can complete spermiogenesis in men with isolated hypogonadotropic hypogonadism (IHH). hCG was administered to 22 men with IHH until maximal testicular growth was achieved.
Report a problemFND-0337267910
08HumanNon-randomized trialEfficacy outcome
In men with complete gonadotropin deficiency, six of 11 became sperm-positive during hCG treatment.
In plain wordsIn men with complete gonadotropin deficiency, six of 11 became sperm-positive during hCG treatment.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseSperm positivity in complete deficiency
Study
n = 11
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Measurements
Men sperm positive
6 men
of 11 with complete gonadotropin deficiency
Source sentences
Summary
Six of 11 men with complete gonadotropin deficiency, defined as an initial mean testicular volume less than 4 mL, became sperm positive during hCG treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
This study was designed to determine whether exogenous hCG alone can complete spermiogenesis in men with isolated hypogonadotropic hypogonadism (IHH). hCG was administered to 22 men with IHH until maximal testicular growth was achieved.
Report a problemFND-0337267906
09HumanNon-randomized trialEfficacy outcome
In hCG-treated men who achieved conception, sperm concentration was less than 10 million/mL in all but 1 man.
In plain wordsIn hCG-treated men who achieved conception, sperm concentration was below 10 million/mL in all but 1 man.
Peptide
hCG (human chorionic gonadotropin)
Outcome
Not applicableSperm concentration at conception
Study
n = 7
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Measurements
Sperm concentration at conception
< 10 million/mL
all but 1 man
Source sentences
Summary
The sperm concentration at the time of conception was less than 10 million/mL in all but 1 man.
2 context sentences(design, population, supporting numbers)
Summary · context
Of 13 men attempting to impregnate their partners, 7 were successful in initiating conception; a total of 8 pregnancies ensued.
Summary · context
This study was designed to determine whether exogenous hCG alone can complete spermiogenesis in men with isolated hypogonadotropic hypogonadism (IHH). hCG was administered to 22 men with IHH until maximal testicular growth was achieved.
Report a problemFND-0337267911
10HumanNon-randomized trialOther
In men receiving hCG for isolated hypogonadotropic hypogonadism, sperm concentration correlated positively with pretreatment testicular volume.
In plain wordsIn men receiving hCG, higher sperm concentration was linked to larger pretreatment testicular volume.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseSperm concentration and pretreatment volume
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Measurements
Correlation of sperm concentration with pretreatment testicular volume (r)
0.65 r
men on hCG
P value
< 0.01 p value
Correlation of sperm concentration with pretreatment testicular volume
Source sentences
Summary
Sperm concentration was highly positively correlated with both pretreatment (r = 0.65; P less than 0.01) and final testicular volume (r = 0.73; P less than 0.0001).
1 context sentence(design, population, supporting numbers)
Summary · context
This study was designed to determine whether exogenous hCG alone can complete spermiogenesis in men with isolated hypogonadotropic hypogonadism (IHH). hCG was administered to 22 men with IHH until maximal testicular growth was achieved.
Report a problemFND-0337267908
11HumanNon-randomized trialOther
In men receiving hCG for isolated hypogonadotropic hypogonadism, sperm concentration correlated positively with final testicular volume.
In plain wordsIn men receiving hCG, higher sperm concentration was linked to larger final testicular volume.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseSperm concentration and final volume
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Measurements
Correlation of sperm concentration with final testicular volume (r)
0.73 r
men on hCG
P value
< 0.0001 p value
Correlation of sperm concentration with final testicular volume
Source sentences
Summary
Sperm concentration was highly positively correlated with both pretreatment (r = 0.65; P less than 0.01) and final testicular volume (r = 0.73; P less than 0.0001).
1 context sentence(design, population, supporting numbers)
Summary · context
This study was designed to determine whether exogenous hCG alone can complete spermiogenesis in men with isolated hypogonadotropic hypogonadism (IHH). hCG was administered to 22 men with IHH until maximal testicular growth was achieved.
Report a problemFND-0337267909

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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