Human parathyroid hormone-(1-34) increases bone mass in ovariectomized and orchidectomized rats.

Hock JM, Gera I, Fonseca J, Raisz LG

Endocrinology1 Jun 1988Cited by 154 (Europe PMC)

PMID3371266DOI10.1210/endo-122-6-2899PepBankPUB-03371266

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In sham-operated female rats, PTH increased total bone calcium per body weight by 16% versus controls.
In plain wordsIn sham-operated female rats, PTH increased bone calcium relative to body weight versus controls.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseBone calcium in sham-operated females
Study
ratn: not reported in source
sham-operated or gonadectomized rats
Comparator
corresponding vehicle control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
8 micrograms/100 g daily · subcutaneous · 12 daysAs given in this study (rat).
Source sentences
Summary
In PTH-treated females, total bone Ca and DW per 100 g BW increased significantly by 16% and 21%, respectively, in sham-operated rats and by 21% and 25%, respectively, in OVX rats compared to the appropriate control values.
2 context sentences(design, population, supporting numbers)
Summary · context
Two weeks after ovariectomy, orchidectomy, or sham operations, 5-week-old rats (eight per group) were given daily sc injections of human PTH (1-34) (8 micrograms/100 g) or vehicle.
Summary · context
After 12 days of treatment, all rats were killed; castration was confirmed, and sera, femurs, tibias, and kidneys were collected.
Report a problemFND-0337126601
02AnimalAnimal study (in vivo)Efficacy outcome
In sham-operated female rats, PTH increased bone dry weight per body weight by 21% versus controls.
In plain wordsIn sham-operated female rats, PTH increased bone dry weight relative to body weight versus controls.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseBone dry weight in sham-operated females
Study
ratn: not reported in source
sham-operated or gonadectomized rats
Comparator
corresponding vehicle control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
8 micrograms/100 g daily · subcutaneous · 12 daysAs given in this study (rat).
Source sentences
Summary
In PTH-treated females, total bone Ca and DW per 100 g BW increased significantly by 16% and 21%, respectively, in sham-operated rats and by 21% and 25%, respectively, in OVX rats compared to the appropriate control values.
2 context sentences(design, population, supporting numbers)
Summary · context
Two weeks after ovariectomy, orchidectomy, or sham operations, 5-week-old rats (eight per group) were given daily sc injections of human PTH (1-34) (8 micrograms/100 g) or vehicle.
Summary · context
After 12 days of treatment, all rats were killed; castration was confirmed, and sera, femurs, tibias, and kidneys were collected.
Report a problemFND-0337126602
03AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized female rats, PTH increased total bone calcium per body weight by 21% versus controls.
In plain wordsIn ovariectomized female rats, PTH increased bone calcium relative to body weight versus controls.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseBone calcium in ovariectomized females
Study
ratn: not reported in source
sham-operated or gonadectomized rats
Comparator
corresponding vehicle control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
8 micrograms/100 g daily · subcutaneous · 12 daysAs given in this study (rat).
Source sentences
Summary
In PTH-treated females, total bone Ca and DW per 100 g BW increased significantly by 16% and 21%, respectively, in sham-operated rats and by 21% and 25%, respectively, in OVX rats compared to the appropriate control values.
2 context sentences(design, population, supporting numbers)
Summary · context
Two weeks after ovariectomy, orchidectomy, or sham operations, 5-week-old rats (eight per group) were given daily sc injections of human PTH (1-34) (8 micrograms/100 g) or vehicle.
Summary · context
After 12 days of treatment, all rats were killed; castration was confirmed, and sera, femurs, tibias, and kidneys were collected.
Report a problemFND-0337126603
04AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized female rats, PTH increased bone dry weight per body weight by 25% versus controls.
In plain wordsIn ovariectomized female rats, PTH increased bone dry weight relative to body weight versus controls.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseBone dry weight in ovariectomized females
Study
ratn: not reported in source
sham-operated or gonadectomized rats
Comparator
corresponding vehicle control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
8 micrograms/100 g daily · subcutaneous · 12 daysAs given in this study (rat).
Source sentences
Summary
In PTH-treated females, total bone Ca and DW per 100 g BW increased significantly by 16% and 21%, respectively, in sham-operated rats and by 21% and 25%, respectively, in OVX rats compared to the appropriate control values.
2 context sentences(design, population, supporting numbers)
Summary · context
Two weeks after ovariectomy, orchidectomy, or sham operations, 5-week-old rats (eight per group) were given daily sc injections of human PTH (1-34) (8 micrograms/100 g) or vehicle.
Summary · context
After 12 days of treatment, all rats were killed; castration was confirmed, and sera, femurs, tibias, and kidneys were collected.
Report a problemFND-0337126604
05AnimalAnimal study (in vivo)Efficacy outcome
In sham-operated male rats, PTH increased total bone calcium per body weight by 34% versus controls.
In plain wordsIn sham-operated male rats, PTH increased bone calcium relative to body weight versus controls.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseBone calcium in sham-operated males
Study
ratn: not reported in source
sham-operated or gonadectomized rats
Comparator
corresponding vehicle control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
8 micrograms/100 g daily · subcutaneous · 12 daysAs given in this study (rat).
Source sentences
Summary
In PTH-treated males, total bone Ca and DW per 100 g BW increased significantly by 34% and 25%, respectively, in sham-operated rats by 32% and 29%, respectively, in ORCHX rats compared to their appropriate control values.
2 context sentences(design, population, supporting numbers)
Summary · context
Two weeks after ovariectomy, orchidectomy, or sham operations, 5-week-old rats (eight per group) were given daily sc injections of human PTH (1-34) (8 micrograms/100 g) or vehicle.
Summary · context
After 12 days of treatment, all rats were killed; castration was confirmed, and sera, femurs, tibias, and kidneys were collected.
Report a problemFND-0337126605
06AnimalAnimal study (in vivo)Efficacy outcome
In sham-operated male rats, PTH increased bone dry weight per body weight by 25% versus controls.
In plain wordsIn sham-operated male rats, PTH increased bone dry weight relative to body weight versus controls.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseBone dry weight in sham-operated males
Study
ratn: not reported in source
sham-operated or gonadectomized rats
Comparator
corresponding vehicle control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
8 micrograms/100 g daily · subcutaneous · 12 daysAs given in this study (rat).
Source sentences
Summary
In PTH-treated males, total bone Ca and DW per 100 g BW increased significantly by 34% and 25%, respectively, in sham-operated rats by 32% and 29%, respectively, in ORCHX rats compared to their appropriate control values.
2 context sentences(design, population, supporting numbers)
Summary · context
Two weeks after ovariectomy, orchidectomy, or sham operations, 5-week-old rats (eight per group) were given daily sc injections of human PTH (1-34) (8 micrograms/100 g) or vehicle.
Summary · context
After 12 days of treatment, all rats were killed; castration was confirmed, and sera, femurs, tibias, and kidneys were collected.
Report a problemFND-0337126606
07AnimalAnimal study (in vivo)Efficacy outcome
In orchidectomized male rats, PTH increased total bone calcium per body weight by 32% versus controls.
In plain wordsIn orchidectomized male rats, PTH increased bone calcium relative to body weight versus controls.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseBone calcium in orchidectomized males
Study
ratn: not reported in source
sham-operated or gonadectomized rats
Comparator
corresponding vehicle control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
8 micrograms/100 g daily · subcutaneous · 12 daysAs given in this study (rat).
Source sentences
Summary
In PTH-treated males, total bone Ca and DW per 100 g BW increased significantly by 34% and 25%, respectively, in sham-operated rats by 32% and 29%, respectively, in ORCHX rats compared to their appropriate control values.
2 context sentences(design, population, supporting numbers)
Summary · context
Two weeks after ovariectomy, orchidectomy, or sham operations, 5-week-old rats (eight per group) were given daily sc injections of human PTH (1-34) (8 micrograms/100 g) or vehicle.
Summary · context
After 12 days of treatment, all rats were killed; castration was confirmed, and sera, femurs, tibias, and kidneys were collected.
Report a problemFND-0337126607
08AnimalAnimal study (in vivo)Efficacy outcome
In orchidectomized male rats, PTH increased bone dry weight per body weight by 29% versus controls.
In plain wordsIn orchidectomized male rats, PTH increased bone dry weight relative to body weight versus controls.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseBone dry weight in orchidectomized males
Study
ratn: not reported in source
sham-operated or gonadectomized rats
Comparator
corresponding vehicle control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
8 micrograms/100 g daily · subcutaneous · 12 daysAs given in this study (rat).
Source sentences
Summary
In PTH-treated males, total bone Ca and DW per 100 g BW increased significantly by 34% and 25%, respectively, in sham-operated rats by 32% and 29%, respectively, in ORCHX rats compared to their appropriate control values.
2 context sentences(design, population, supporting numbers)
Summary · context
Two weeks after ovariectomy, orchidectomy, or sham operations, 5-week-old rats (eight per group) were given daily sc injections of human PTH (1-34) (8 micrograms/100 g) or vehicle.
Summary · context
After 12 days of treatment, all rats were killed; castration was confirmed, and sera, femurs, tibias, and kidneys were collected.
Report a problemFND-0337126608
09AnimalAnimal study (in vivo)Safety outcome
In rats, serum calcium was normal and comparable across all groups, including PTH groups.
In plain wordsIn rats, serum calcium was normal and similar across PTH and control groups.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeSerum calcium
Study
ratn: not reported in source
sham-operated or gonadectomized rats
Comparator
corresponding vehicle control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
8 micrograms/100 g daily · subcutaneous · 12 daysAs given in this study (rat).
Source sentences
Summary
Serum Ca, creatinine, and alkaline phosphatase levels were normal and comparable in all rats.
2 context sentences(design, population, supporting numbers)
Summary · context
Two weeks after ovariectomy, orchidectomy, or sham operations, 5-week-old rats (eight per group) were given daily sc injections of human PTH (1-34) (8 micrograms/100 g) or vehicle.
Summary · context
After 12 days of treatment, all rats were killed; castration was confirmed, and sera, femurs, tibias, and kidneys were collected.
Report a problemFND-0337126609
10AnimalAnimal study (in vivo)Safety outcome
In rats, serum creatinine was normal and comparable across all groups, including PTH groups.
In plain wordsIn rats, serum creatinine was normal and similar across PTH and control groups.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeSerum creatinine
Study
ratn: not reported in source
sham-operated or gonadectomized rats
Comparator
corresponding vehicle control
Outcome group
Kidney function · Kidney and urinary
Studied dose
8 micrograms/100 g daily · subcutaneous · 12 daysAs given in this study (rat).
Source sentences
Summary
Serum Ca, creatinine, and alkaline phosphatase levels were normal and comparable in all rats.
2 context sentences(design, population, supporting numbers)
Summary · context
Two weeks after ovariectomy, orchidectomy, or sham operations, 5-week-old rats (eight per group) were given daily sc injections of human PTH (1-34) (8 micrograms/100 g) or vehicle.
Summary · context
After 12 days of treatment, all rats were killed; castration was confirmed, and sera, femurs, tibias, and kidneys were collected.
Report a problemFND-0337126610
11AnimalAnimal study (in vivo)Efficacy outcome
In rats, serum alkaline phosphatase was normal and comparable across all groups, including PTH groups.
In plain wordsIn rats, serum alkaline phosphatase was normal and similar across PTH and control groups.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeSerum alkaline phosphatase
Study
ratn: not reported in source
sham-operated or gonadectomized rats
Comparator
corresponding vehicle control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
8 micrograms/100 g daily · subcutaneous · 12 daysAs given in this study (rat).
Source sentences
Summary
Serum Ca, creatinine, and alkaline phosphatase levels were normal and comparable in all rats.
2 context sentences(design, population, supporting numbers)
Summary · context
Two weeks after ovariectomy, orchidectomy, or sham operations, 5-week-old rats (eight per group) were given daily sc injections of human PTH (1-34) (8 micrograms/100 g) or vehicle.
Summary · context
After 12 days of treatment, all rats were killed; castration was confirmed, and sera, femurs, tibias, and kidneys were collected.
Report a problemFND-0337126611

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.