In sleep-deprived rats, intraventricular antiserum to DSIP blocked the increase in plasma growth hormone.
In plain wordsIn rats, blocking natural DSIP with an antiserum stopped the growth hormone rise that follows sleep loss.
- Outcome
- DecreaseSleep-deprivation-induced plasma GH increase after DSIP antiserum
- Study
ratn: not reported in source
- Comparator
- Normal rabbit serum
- Outcome group
- Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
These increases were blocked by microinjection into the third cerebral ventricle of highly specific antiserum to DSIP.
2 context sentences(design, population, supporting numbers)
Sleep deprivation by this method caused a significant increase in GH release, as indicated by the increase in plasma GH concentrations (P less than 0.01), and also in the amount of slow-wave sleep (SWS) (P less than 0.001) above initial values after removal of the animals from the rotating wheel.
To examine the role of delta sleep-inducing peptide (DSIP) in sleep-related growth hormone (GH) release, male rats were deprived of sleep for 4 hr by placing them on a slowly rotating wheel.
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).