Baboon corpus luteum oxytocin: an intragonadal peptide modulator of luteal function.

Khan-Dawood FS, Huang JC, Dawood MY

American journal of obstetrics and gynecology1 Apr 1988Cited by 14 (Europe PMC)

PMID3364500DOI10.1016/0002-9378(88)90089-0PepBankPUB-03364500

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

5 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Efficacy outcome
In dispersed baboon luteal cells from the early luteal phase, oxytocin inhibited basal progesterone production.
In plain wordsIn baboon ovary cells from the early phase, oxytocin lowered progesterone output at rest.
Peptide
Oxytocin
Outcome
DecreaseBasal progesterone production, early luteal phase
Study
Baboon (Papio anubis)n: not reported in source
Dispersed luteal cells, early luteal phase
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
4 to 800 mUAs given in this study (Baboon (Papio anubis)).
Source sentences
Summary
In the early luteal phase oxytocin (4 to 800 mU; 1 mU is equivalent to 2 ng) inhibited basal and human chorionic gonadotropin-stimulated progesterone production by dispersed luteal cells
1 context sentence(design, population, supporting numbers)
Summary · context
Oxytocin concentrations were determined in baboon (Papio anubis) corpora lutea, and the effect of oxytocin on dispersed luteal cell progesterone production was evaluated.
Report a problemFND-0336450007
02LabIn vitro (cells)Efficacy outcome
In dispersed baboon luteal cells from the early luteal phase, oxytocin inhibited human chorionic gonadotropin-stimulated progesterone production.
In plain wordsIn baboon ovary cells from the early phase, oxytocin lowered progesterone output stimulated by hCG.
Peptide
Oxytocin
Outcome
DecreasehCG-stimulated progesterone production, early luteal phase
Study
Baboon (Papio anubis)n: not reported in source
Dispersed luteal cells, early luteal phase
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
4 to 800 mUAs given in this study (Baboon (Papio anubis)).
Source sentences
Summary
In the early luteal phase oxytocin (4 to 800 mU; 1 mU is equivalent to 2 ng) inhibited basal and human chorionic gonadotropin-stimulated progesterone production by dispersed luteal cells
1 context sentence(design, population, supporting numbers)
Summary · context
Oxytocin concentrations were determined in baboon (Papio anubis) corpora lutea, and the effect of oxytocin on dispersed luteal cell progesterone production was evaluated.
Report a problemFND-0336450008
03LabIn vitro (cells)Efficacy outcome
In dispersed baboon luteal cells from the late luteal phase, oxytocin inhibited human chorionic gonadotropin-stimulated progesterone output.
In plain wordsIn baboon ovary cells from the late phase, oxytocin lowered progesterone output stimulated by hCG.
Peptide
Oxytocin
Outcome
DecreasehCG-stimulated progesterone output, late luteal phase
Study
Baboon (Papio anubis)n: not reported in source
Dispersed luteal cells, late luteal phase
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
200 to 800 mUAs given in this study (Baboon (Papio anubis)).
Source sentences
Summary
but in the late luteal phase 200 to 800 mU oxytocin inhibited only human chorionic gonadotropin-stimulated progesterone output.
1 context sentence(design, population, supporting numbers)
Summary · context
Oxytocin concentrations were determined in baboon (Papio anubis) corpora lutea, and the effect of oxytocin on dispersed luteal cell progesterone production was evaluated.
Report a problemFND-0336450009
04LabIn vitro (cells)Efficacy outcome
In dispersed baboon luteal cells from the late luteal phase, oxytocin inhibited only human chorionic gonadotropin-stimulated progesterone output, not basal production.
In plain wordsIn baboon ovary cells from the late phase, oxytocin did not lower progesterone output at rest.
Peptide
Oxytocin
Outcome
No significant changeBasal progesterone production, late luteal phase
Study
Baboon (Papio anubis)n: not reported in source
Dispersed luteal cells, late luteal phase
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
200 to 800 mUAs given in this study (Baboon (Papio anubis)).
Source sentences
Summary
but in the late luteal phase 200 to 800 mU oxytocin inhibited only human chorionic gonadotropin-stimulated progesterone output.
1 context sentence(design, population, supporting numbers)
Summary · context
Oxytocin concentrations were determined in baboon (Papio anubis) corpora lutea, and the effect of oxytocin on dispersed luteal cell progesterone production was evaluated.
Report a problemFND-0336450010
05LabIn vitro (cells)Efficacy outcome
In dispersed baboon luteal cells from the midluteal phase, oxytocin did not affect progesterone production.
In plain wordsIn baboon ovary cells from the middle phase, oxytocin did not change progesterone output.
Peptide
Oxytocin
Outcome
No significant changeProgesterone production, midluteal phase
Study
Baboon (Papio anubis)n: not reported in source
Dispersed luteal cells, midluteal phase
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Oxytocin did not affect luteal cell progesterone production in the midluteal phase.
1 context sentence(design, population, supporting numbers)
Summary · context
Oxytocin concentrations were determined in baboon (Papio anubis) corpora lutea, and the effect of oxytocin on dispersed luteal cell progesterone production was evaluated.
Report a problemFND-0336450011

Natural levels measured6

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

06AnimalEndogenous levelAnimal study (in vivo)Mechanism
In baboons, oxytocin concentration in corpora lutea increased significantly from the early luteal phase to a peak in the midluteal phase.
In plain wordsIn baboons, the body's own oxytocin in the ovary's corpus luteum rose from the early phase to a midphase peak.
Peptide
Oxytocin
Outcome
IncreaseOxytocin concentration in corpora lutea across the luteal phase
Study
Baboon (Papio anubis)n: not reported in source
Comparator
Early luteal phase
Outcome group
Endogenous peptide levels · Reproductive and sexual health
Measurements
Oxytocin concentration
2.1 ng/gm
early luteal phase
Oxytocin concentration
18.1 ng/gm wet weight
midluteal phase
Source sentences
Summary
Oxytocin concentrations increased significantly from an early luteal phase value of 2.1 +/- 1.1 ng/gm to a peak concentration of 18.1 +/- 4.3 ng/gm wet weight in midluteal phase corpora lutea.
1 context sentence(design, population, supporting numbers)
Summary · context
Oxytocin concentrations were determined in baboon (Papio anubis) corpora lutea, and the effect of oxytocin on dispersed luteal cell progesterone production was evaluated.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0336450001
07AnimalEndogenous levelAnimal study (in vivo)Mechanism
In baboons, corpora albicantia and ovarian stroma had comparatively low oxytocin concentrations.
In plain wordsIn baboons, ovary tissue other than the corpus luteum held little of the body's own oxytocin.
Peptide
Oxytocin
Outcome
DecreaseOxytocin concentration in corpora albicantia and ovarian stroma
Study
Baboon (Papio anubis)n: not reported in source
Comparator
Corpora lutea
Outcome group
Endogenous peptide levels · Reproductive and sexual health
Source sentences
Summary
Corpora albicantia and ovarian stroma had comparatively low oxytocin concentrations.
1 context sentence(design, population, supporting numbers)
Summary · context
Oxytocin concentrations were determined in baboon (Papio anubis) corpora lutea, and the effect of oxytocin on dispersed luteal cell progesterone production was evaluated.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0336450002
08AnimalEndogenous levelAnimal study (in vivo)Other
Reverse-phase HPLC of baboon corpora lutea extracts gave a peptide peak similar to a standard oxytocin peak.
In plain wordsIn baboons, lab tests of the corpus luteum found a peptide that matched the body's own oxytocin.
Peptide
Oxytocin
Outcome
Not applicableIdentity of luteal peptide by HPLC
Study
Baboon (Papio anubis)n: not reported in source
Outcome group
Endogenous peptide levels · Reproductive and sexual health
Source sentences
Summary
Reverse-phase high-pressure liquid chromatography of corpora lutea extracts gave a peptide peak (retention time, 17.25 min) similar to a standard oxytocin peak.
1 context sentence(design, population, supporting numbers)
Summary · context
Oxytocin concentrations were determined in baboon (Papio anubis) corpora lutea, and the effect of oxytocin on dispersed luteal cell progesterone production was evaluated.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0336450003
09AnimalEndogenous levelAnimal study (in vivo)Mechanism
In baboons, plasma oxytocin was significantly higher in the ovarian vein draining a corpus luteum than in the contralateral side or the femoral vein.
In plain wordsIn baboons, blood leaving the corpus luteum held more of the body's own oxytocin than blood elsewhere.
Peptide
Oxytocin
Outcome
IncreasePlasma oxytocin in ovarian vein draining a corpus luteum
Study
Baboon (Papio anubis)n: not reported in source
Comparator
Contralateral ovarian vein and femoral vein
Outcome group
Endogenous peptide levels · Reproductive and sexual health
Source sentences
Summary
Plasma oxytocin levels, which were significantly higher in the ovarian vein draining a corpus luteum than in the contralateral side or the femoral vein, declined significantly after luteectomy.
1 context sentence(design, population, supporting numbers)
Summary · context
Oxytocin concentrations were determined in baboon (Papio anubis) corpora lutea, and the effect of oxytocin on dispersed luteal cell progesterone production was evaluated.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0336450004
10AnimalEndogenous levelAnimal study (in vivo)Mechanism
In baboons, plasma oxytocin declined significantly after luteectomy.
In plain wordsIn baboons, the body's own oxytocin in the blood fell after the corpus luteum was removed.
Peptide
Oxytocin
Outcome
DecreasePlasma oxytocin after luteectomy
Study
Baboon (Papio anubis)n: not reported in source
Outcome group
Endogenous peptide levels · Reproductive and sexual health
Source sentences
Summary
Plasma oxytocin levels, which were significantly higher in the ovarian vein draining a corpus luteum than in the contralateral side or the femoral vein, declined significantly after luteectomy.
1 context sentence(design, population, supporting numbers)
Summary · context
Oxytocin concentrations were determined in baboon (Papio anubis) corpora lutea, and the effect of oxytocin on dispersed luteal cell progesterone production was evaluated.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0336450005
11AnimalEndogenous levelAnimal study (in vivo)Mechanism
In baboon corpora lutea, oxytocin was localized in luteal cells by immunocytochemistry.
In plain wordsIn baboons, the body's own oxytocin was found inside corpus luteum cells.
Peptide
Oxytocin
Outcome
Not applicableLocalization of oxytocin in luteal cells
Study
Baboon (Papio anubis)n: not reported in source
Outcome group
Endogenous peptide levels · Reproductive and sexual health
Source sentences
Summary
Oxytocin was localized by immunocytochemical methods in luteal cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Oxytocin concentrations were determined in baboon (Papio anubis) corpora lutea, and the effect of oxytocin on dispersed luteal cell progesterone production was evaluated.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0336450006

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:52 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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