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Study · Measured the body's own peptide · 1988

4 results

Influences of aging and dietary restriction on serum thymosin alpha 1 levels in mice.

Weindruch R, Naylor PH, Goldstein AL, Walford RL

Journal of gerontology1 Mar 1988Cited by 111 (Europe PMC)

PMID3346517 (opens in a new tab)DOI10.1093/geronj/43.2.b40 (opens in a new tab)PepBankPUB-03346517
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In female mice, the body's own serum thymosin alpha‑1 was highest at 3 weeks of age and fell sharply by 2 months of age.

    In plain wordsIn mice, the body's own thymosin alpha‑1 level in blood was highest at 3 weeks and fell sharply by 2 months.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseSerum T alpha 1 level by age
    Study

    mousen: not reported in source

    Female mice from a long-lived strain
    Outcome group
    Aging markers · Aging and longevity

    Measurements

    T alpha 1 level
    ≈ 60 ng/ml
    3 wk
    T alpha 1 level
    ≈ 20 ng/ml
    2 mo, normal or restricted diet

    Source sentences

    Summary
    The average T alpha 1 level was highest (approximately 60 ng/ml) at 3 wk and fell sharply such that 2 mo old mice fed either normal (N, approximately 80% of ad libitum intake) or restricted (R, approximately 50% of ad libitum intake) diets averaged approximately 20 ng/ml.
    1 context sentence
    Summary · context
    Influences of age (3 wk, 2, 7, 19, or 26 mo), long-term dietary restriction (DR) started at 3 wk of age, and acute fasting state on serum thymosin alpha 1 (T alpha 1) levels were measured by radioimmunoassay in female mice from a long-lived strain.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In female mice, age-related declines in serum thymosin alpha‑1 after 2 months were mild and significant only in restricted-diet mice bled 2-4 h after feeding.

    In plain wordsIn mice, later declines in the body's own thymosin alpha‑1 were mild and significant only in diet-restricted mice bled soon after feeding.

    Peptide
    Thymosin alpha-1
    Outcome
    MixedSerum T alpha 1 decline after 2 months of age
    Study

    mousen: not reported in source

    Female mice from a long-lived strain
    Outcome group
    Aging markers · Aging and longevity

    Source sentences

    Summary
    Any age-related declines after 2 mo of age were mild and statistically significant only for R mice bled 2-4 h (but not 24-48 h) post-feeding.
    1 context sentence
    Summary · context
    Influences of age (3 wk, 2, 7, 19, or 26 mo), long-term dietary restriction (DR) started at 3 wk of age, and acute fasting state on serum thymosin alpha 1 (T alpha 1) levels were measured by radioimmunoassay in female mice from a long-lived strain.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In female mice, serum thymosin alpha‑1 was lower with the restricted diet than with the normal diet in one experiment at 19 months but not in another at 26 months.

    In plain wordsIn mice, the body's own thymosin alpha‑1 was lower with a restricted diet in one experiment at 19 months but not at 26 months.

    Peptide
    Thymosin alpha-1
    Outcome
    MixedSerum T alpha 1 in restricted versus normal diet mice
    Study

    mousen: not reported in source

    Female mice from a long-lived strain
    Comparator
    Normal diet (N)
    Outcome group
    Aging markers · Aging and longevity

    Source sentences

    Summary
    T alpha 1 levels were lower in group R than in group N mice in one experiment at 19 mo of age but not in another at 26 mo.
    1 context sentence
    Summary · context
    Influences of age (3 wk, 2, 7, 19, or 26 mo), long-term dietary restriction (DR) started at 3 wk of age, and acute fasting state on serum thymosin alpha 1 (T alpha 1) levels were measured by radioimmunoassay in female mice from a long-lived strain.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  4. 04AnimalEndogenous levelAnimal study (in vivo)Other

    In female mice, the early-life decline in serum thymosin alpha‑1 appeared uninfluenced by dietary restriction.

    In plain wordsIn mice, the early drop in the body's own thymosin alpha‑1 appeared not to depend on dietary restriction.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeEffect of dietary restriction on early-life decline in T alpha 1
    Study

    mousen: not reported in source

    Female mice from a long-lived strain
    Comparator
    Normal diet (N)
    Outcome group
    Aging markers · Aging and longevity

    Source sentences

    Summary
    The decline with age in serum T alpha 1 levels is mainly a very early life event for mice of this hybrid strain and appears uninfluenced by DR.
    1 context sentence
    Summary · context
    Influences of age (3 wk, 2, 7, 19, or 26 mo), long-term dietary restriction (DR) started at 3 wk of age, and acute fasting state on serum thymosin alpha 1 (T alpha 1) levels were measured by radioimmunoassay in female mice from a long-lived strain.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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