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Study · Non-randomized trial · 1987

3 results

Local effect of vasoactive intestinal polypeptide on human sweat-gland function.

Yamashita Y, Ogawa T, Ohnishi N, Imamura R, Sugenoya J

The Japanese journal of physiology1 Jan 1987Cited by 29 (Europe PMC)

PMID3329689 (opens in a new tab)DOI10.2170/jjphysiol.37.929 (opens in a new tab)PepBankPUB-03329689
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In people in a cool environment, intradermal VIP alone did not cause sweat secretion.

    In plain wordsIn people in a cool room, VIP injected into the skin did not make the skin sweat on its own.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    No significant changeSweat secretion with VIP alone, cool environment
    Study

    n: not reported in source

    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · intradermalAs given in this study (human).

    Source sentences

    Summary
    In a cool environment (Ta, 23 degrees C), VIP failed to cause sweat secretion
    1 context sentence
    Summary · context
    VIP, methacholine chloride (MCH), or VIP plus MCH dissolved in 0.1 ml of 0.9% NaCl solution to a specified concentration was injected intradermally at the center of a forearm test area of 15 cm2 and the sweat rate was recorded continuously by capacitance hygrometry.
  2. 02HumanNon-randomized trialEfficacy outcome

    In people in a cool environment, intradermal VIP added to methacholine increased the methacholine-induced sweat rate, most at the concentration that raised local skin temperature most.

    In plain wordsIn people in a cool room, VIP raised the sweating that methacholine caused, compared with methacholine alone.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseMethacholine-induced sweat rate, cool environment
    Study

    n: not reported in source

    Comparator
    Methacholine chloride alone
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    10(-5) g/ml (largest effect) · intradermalAs given in this study (human).

    Source sentences

    Summary
    but increased the rate of MCH-induced sweating, most markedly at a concentration of 10(-5) g/ml, where the rise in local skin temperature was the greatest.
    1 context sentence
    Summary · context
    VIP, methacholine chloride (MCH), or VIP plus MCH dissolved in 0.1 ml of 0.9% NaCl solution to a specified concentration was injected intradermally at the center of a forearm test area of 15 cm2 and the sweat rate was recorded continuously by capacitance hygrometry.
  3. 03HumanNon-randomized trialEfficacy outcome

    In a hot environment on skin anaesthetized by nerve block, the sweat-facilitating effect of VIP was less obvious and less consistent.

    In plain wordsIn a hot room, on numbed skin, the extra sweating from VIP was weaker and less consistent.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    MixedSweat-facilitatory effect of VIP under nerve block, hot environment
    Study

    n: not reported in source

    Comparator
    Methacholine chloride alone
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · intradermalAs given in this study (human).

    Source sentences

    Summary
    On an area anesthetized by nerve block in a hot environment (Ta, 35 degrees C), the effect was less obvious and less consistent
    1 context sentence
    Summary · context
    VIP, methacholine chloride (MCH), or VIP plus MCH dissolved in 0.1 ml of 0.9% NaCl solution to a specified concentration was injected intradermally at the center of a forearm test area of 15 cm2 and the sweat rate was recorded continuously by capacitance hygrometry.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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