Effects of indomethacin and (+/-)-propranolol on the cardiovascular and renin responses to vasoactive intestinal polypeptide (VIP) infusion in man.

Unwin RJ, Reed T, Thom S, Calam J, Peart WS

British journal of clinical pharmacology1 May 1987Cited by 6 (Europe PMC)

PMID3297124PMCIDPMC1386187DOI10.1111/j.1365-2125.1987.tb03087.xPepBankPUB-03297124

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study13

6 results from studies that gave the peptide. 6 results from people.

01HumanRandomized controlled trialActivity measurement
In healthy men, intravenous VIP infusion produced cutaneous flushing.
In plain wordsIn healthy men, VIP infusion made the skin flush.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseCutaneous flushing
Study
n = 6
Outcome group
Adverse events · Whole body
Studied dose
6 pmol kg-1 min-1 · intravenousAs given in this study (human).
Source sentences
Summary
Intravenous VIP (calculated dose: 6 pmol kg-1 min-1) produced cutaneous flushing, increased HR and PRA, decreased FVR, but did not alter mean arterial BP or AVP levels.
1 context sentence(design, population, supporting numbers)
Summary · context
To examine the relative importance of prostaglandins and reflex sympathetic activation in the haemodynamic and renin responses to VIP infusion in man, we completed two randomised single-blind crossover studies in two groups of six healthy male volunteers (aged 24-35 years).
Report a problemFND-0329712401
02HumanRandomized controlled trialActivity measurement
In healthy men, intravenous VIP infusion increased heart rate.
In plain wordsIn healthy men, VIP infusion raised heart rate.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseHeart rate
Study
n = 6
Outcome group
Heart function · Cardiovascular
Studied dose
6 pmol kg-1 min-1 · intravenousAs given in this study (human).
Source sentences
Summary
Intravenous VIP (calculated dose: 6 pmol kg-1 min-1) produced cutaneous flushing, increased HR and PRA, decreased FVR, but did not alter mean arterial BP or AVP levels.
1 context sentence(design, population, supporting numbers)
Summary · context
To examine the relative importance of prostaglandins and reflex sympathetic activation in the haemodynamic and renin responses to VIP infusion in man, we completed two randomised single-blind crossover studies in two groups of six healthy male volunteers (aged 24-35 years).
Report a problemFND-0329712402
03HumanRandomized controlled trialActivity measurement
In healthy men, intravenous VIP infusion increased plasma renin activity.
In plain wordsIn healthy men, VIP infusion raised renin activity in the blood.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreasePlasma renin activity
Study
n = 6
Outcome group
Hormone levels · Endocrine and hormones
Studied dose
6 pmol kg-1 min-1 · intravenousAs given in this study (human).
Source sentences
Summary
Intravenous VIP (calculated dose: 6 pmol kg-1 min-1) produced cutaneous flushing, increased HR and PRA, decreased FVR, but did not alter mean arterial BP or AVP levels.
1 context sentence(design, population, supporting numbers)
Summary · context
To examine the relative importance of prostaglandins and reflex sympathetic activation in the haemodynamic and renin responses to VIP infusion in man, we completed two randomised single-blind crossover studies in two groups of six healthy male volunteers (aged 24-35 years).
Report a problemFND-0329712403
04HumanRandomized controlled trialActivity measurement
In healthy men, intravenous VIP infusion decreased forearm vascular resistance.
In plain wordsIn healthy men, VIP infusion lowered resistance to blood flow in the forearm.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseForearm vascular resistance
Study
n = 6
Outcome group
Vascular function · Cardiovascular
Studied dose
6 pmol kg-1 min-1 · intravenousAs given in this study (human).
Source sentences
Summary
Intravenous VIP (calculated dose: 6 pmol kg-1 min-1) produced cutaneous flushing, increased HR and PRA, decreased FVR, but did not alter mean arterial BP or AVP levels.
1 context sentence(design, population, supporting numbers)
Summary · context
To examine the relative importance of prostaglandins and reflex sympathetic activation in the haemodynamic and renin responses to VIP infusion in man, we completed two randomised single-blind crossover studies in two groups of six healthy male volunteers (aged 24-35 years).
Report a problemFND-0329712404
05HumanRandomized controlled trialActivity measurement
In healthy men, intravenous VIP infusion did not alter mean arterial blood pressure.
In plain wordsIn healthy men, VIP infusion did not change mean blood pressure.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeMean arterial blood pressure
Study
n = 6
Outcome group
Blood pressure · Cardiovascular
Studied dose
6 pmol kg-1 min-1 · intravenousAs given in this study (human).
Source sentences
Summary
Intravenous VIP (calculated dose: 6 pmol kg-1 min-1) produced cutaneous flushing, increased HR and PRA, decreased FVR, but did not alter mean arterial BP or AVP levels.
1 context sentence(design, population, supporting numbers)
Summary · context
To examine the relative importance of prostaglandins and reflex sympathetic activation in the haemodynamic and renin responses to VIP infusion in man, we completed two randomised single-blind crossover studies in two groups of six healthy male volunteers (aged 24-35 years).
Report a problemFND-0329712405
06HumanRandomized controlled trialActivity measurement
In healthy men, intravenous VIP infusion did not alter plasma arginine vasopressin levels.
In plain wordsIn healthy men, VIP infusion did not change blood vasopressin levels.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changePlasma arginine vasopressin
Study
n = 6
Outcome group
Hormone levels · Endocrine and hormones
Studied dose
6 pmol kg-1 min-1 · intravenousAs given in this study (human).
Source sentences
Summary
Intravenous VIP (calculated dose: 6 pmol kg-1 min-1) produced cutaneous flushing, increased HR and PRA, decreased FVR, but did not alter mean arterial BP or AVP levels.
1 context sentence(design, population, supporting numbers)
Summary · context
To examine the relative importance of prostaglandins and reflex sympathetic activation in the haemodynamic and renin responses to VIP infusion in man, we completed two randomised single-blind crossover studies in two groups of six healthy male volunteers (aged 24-35 years).
Report a problemFND-0329712406

Studies that did not test the peptide alone7

In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

07HumanNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneRandomized controlled trialMechanism
In healthy men, indomethacin pretreatment reduced the absolute rise in plasma renin activity during VIP infusion.
In plain wordsIn healthy men, indomethacin lowered the absolute rise in renin activity that VIP infusion caused.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseAbsolute rise in plasma renin activity during VIP with indomethacin
Study
n = 6
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
Although indomethacin and propranolol reduced the absolute rise in PRA and HR, respectively, during VIP infusion
1 context sentence(design, population, supporting numbers)
Summary · context
To examine the relative importance of prostaglandins and reflex sympathetic activation in the haemodynamic and renin responses to VIP infusion in man, we completed two randomised single-blind crossover studies in two groups of six healthy male volunteers (aged 24-35 years).
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-0329712407
08HumanNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneRandomized controlled trialMechanism
In healthy men, propranolol pretreatment reduced the absolute rise in heart rate during VIP infusion.
In plain wordsIn healthy men, propranolol lowered the absolute rise in heart rate that VIP infusion caused.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseAbsolute rise in heart rate during VIP with propranolol
Study
n = 6
Outcome group
Receptor activity and mechanism · Cardiovascular
Source sentences
Summary
Although indomethacin and propranolol reduced the absolute rise in PRA and HR, respectively, during VIP infusion
1 context sentence(design, population, supporting numbers)
Summary · context
To examine the relative importance of prostaglandins and reflex sympathetic activation in the haemodynamic and renin responses to VIP infusion in man, we completed two randomised single-blind crossover studies in two groups of six healthy male volunteers (aged 24-35 years).
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-0329712408
09HumanNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneRandomized controlled trialMechanism
In healthy men, the percentage rise in plasma renin activity during VIP infusion with indomethacin was no different from control.
In plain wordsIn healthy men, indomethacin did not change the percentage rise in renin activity that VIP caused, compared with control.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changePercentage rise in plasma renin activity during VIP with indomethacin
Study
n = 6
Comparator
Control
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
Although indomethacin and propranolol reduced the absolute rise in PRA and HR, respectively, during VIP infusion, the percentage changes were no different from control.
1 context sentence(design, population, supporting numbers)
Summary · context
To examine the relative importance of prostaglandins and reflex sympathetic activation in the haemodynamic and renin responses to VIP infusion in man, we completed two randomised single-blind crossover studies in two groups of six healthy male volunteers (aged 24-35 years).
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-0329712409
10HumanNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneRandomized controlled trialMechanism
In healthy men, the percentage rise in heart rate during VIP infusion with propranolol was no different from control.
In plain wordsIn healthy men, propranolol did not change the percentage rise in heart rate that VIP caused, compared with control.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changePercentage rise in heart rate during VIP with propranolol
Study
n = 6
Comparator
Control
Outcome group
Receptor activity and mechanism · Cardiovascular
Source sentences
Summary
Although indomethacin and propranolol reduced the absolute rise in PRA and HR, respectively, during VIP infusion, the percentage changes were no different from control.
1 context sentence(design, population, supporting numbers)
Summary · context
To examine the relative importance of prostaglandins and reflex sympathetic activation in the haemodynamic and renin responses to VIP infusion in man, we completed two randomised single-blind crossover studies in two groups of six healthy male volunteers (aged 24-35 years).
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-0329712410
11HumanNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneRandomized controlled trialMechanism
In healthy men, indomethacin did not alter the flush response to VIP.
In plain wordsIn healthy men, indomethacin did not change the skin flush that VIP caused.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeFlush response to VIP with indomethacin
Study
n = 6
Outcome group
Receptor activity and mechanism · Skin and wound
Source sentences
Summary
Neither drug altered the flush response to VIP and propranolol did not affect the fall in FVR.
1 context sentence(design, population, supporting numbers)
Summary · context
To examine the relative importance of prostaglandins and reflex sympathetic activation in the haemodynamic and renin responses to VIP infusion in man, we completed two randomised single-blind crossover studies in two groups of six healthy male volunteers (aged 24-35 years).
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-0329712411
12HumanNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneRandomized controlled trialMechanism
In healthy men, propranolol did not alter the flush response to VIP.
In plain wordsIn healthy men, propranolol did not change the skin flush that VIP caused.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeFlush response to VIP with propranolol
Study
n = 6
Outcome group
Receptor activity and mechanism · Skin and wound
Source sentences
Summary
Neither drug altered the flush response to VIP and propranolol did not affect the fall in FVR.
1 context sentence(design, population, supporting numbers)
Summary · context
To examine the relative importance of prostaglandins and reflex sympathetic activation in the haemodynamic and renin responses to VIP infusion in man, we completed two randomised single-blind crossover studies in two groups of six healthy male volunteers (aged 24-35 years).
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-0329712412
13HumanNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneRandomized controlled trialMechanism
In healthy men, propranolol did not affect the fall in forearm vascular resistance caused by VIP.
In plain wordsIn healthy men, propranolol did not change the fall in forearm vascular resistance that VIP caused.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeFall in forearm vascular resistance during VIP with propranolol
Study
n = 6
Outcome group
Receptor activity and mechanism · Cardiovascular
Source sentences
Summary
propranolol did not affect the fall in FVR.
1 context sentence(design, population, supporting numbers)
Summary · context
To examine the relative importance of prostaglandins and reflex sympathetic activation in the haemodynamic and renin responses to VIP infusion in man, we completed two randomised single-blind crossover studies in two groups of six healthy male volunteers (aged 24-35 years).
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-0329712413

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 19:08 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

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