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Study · Randomized controlled trial · n = 50 · 1988

4 results

Gallium nitrate for acute treatment of cancer-related hypercalcemia. A randomized, double-blind comparison to calcitonin.

Warrell RP Jr, Israel R, Frisone M, Snyder T, Gaynor JJ, Bockman RS

Annals of internal medicine1 May 1988Cited by 94 (Europe PMC)

PMID3282463 (opens in a new tab)DOI10.7326/0003-4819-108-5-669 (opens in a new tab)PepBankPUB-03282463
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In cancer-related hypercalcemia, salmon calcitonin achieved normocalcemia in 8 of 26 patients versus eighteen of twenty-four with gallium nitrate (P = 0.002).

    In plain wordsIn cancer-related hypercalcemia, salmon calcitonin achieved normocalcemia less often than gallium nitrate.

    Peptide
    Calcitonin-salmon
    Outcome
    DecreaseAchievement of normocalcemia
    Study

    n = 50

    Comparator
    Gallium nitrate
    Outcome group
    Electrolyte balance · Endocrine and hormones
    Studied dose
    8 IU/kg every 6 hours · intramuscular · 5 daysAs given in this study (human).

    Measurements

    Normocalcemia
    8 patients
    calcitonin
    Treated
    26 patients
    calcitonin
    Normocalcemia
    18 patients
    gallium nitrate
    Treated
    24 patients
    gallium nitrate
    Observed difference
    44%
    gallium nitrate minus calcitonin
    95% confidence interval
    19 to 69%
    gallium nitrate minus calcitonin
    P value
    0.002
    gallium nitrate versus calcitonin

    Source sentences

    Summary
    Eighteen of twenty-four patients who received gallium nitrate achieved normocalcemia compared with 8 of 26 patients who received calcitonin for an observed difference of 44% (95% confidence interval, 19% to 69%; P = 0.002).
    2 context sentences
    Summary · context
    Randomized, double-blind comparison of active treatments.
    Summary · context
    Gallium nitrate 200 mg/m2 body surface area for 5 days by continuous intravenous infusion, or salmon calcitonin 8 IU/kg body weight every 6 hours for 5 days by intramuscular injection.
  2. 02HumanRandomized controlled trialOther

    In cancer-related hypercalcemia, mean daily furosemide dose was similar with salmon calcitonin and gallium nitrate.

    In plain wordsIn cancer-related hypercalcemia, daily furosemide dose was similar with salmon calcitonin and gallium nitrate.

    Peptide
    Calcitonin-salmon
    Outcome
    Direction not reportedDaily furosemide dose
    Study

    n = 50

    Comparator
    Gallium nitrate
    Outcome group
    Concomitant Medication · Whole body
    Studied dose
    8 IU/kg every 6 hours · intramuscular · 5 daysAs given in this study (human).

    Source sentences

    Summary
    Mean daily fluid intake and mean daily dose of furosemide were similar in both treatment groups.
    2 context sentences
    Summary · context
    Randomized, double-blind comparison of active treatments.
    Summary · context
    Gallium nitrate 200 mg/m2 body surface area for 5 days by continuous intravenous infusion, or salmon calcitonin 8 IU/kg body weight every 6 hours for 5 days by intramuscular injection.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In cancer-related hypercalcemia, median normocalcemia before further therapy lasted 1 day with calcitonin versus 6 days with gallium nitrate (P less than 0.001).

    In plain wordsIn cancer-related hypercalcemia, normocalcemia before further therapy lasted less time with calcitonin than with gallium nitrate.

    Peptide
    Calcitonin-salmon
    Outcome
    DecreaseNormocalcemia duration before further therapy
    Study

    n: not reported in source

    Comparator
    Gallium nitrate
    Outcome group
    Electrolyte balance · Endocrine and hormones
    Studied dose
    8 IU/kg every 6 hours · intramuscular · 5 daysAs given in this study (human).

    Measurements

    Median normocalcemia duration
    1 day
    calcitonin
    Median normocalcemia duration
    6 days
    gallium nitrate
    P value
    < 0.001
    gallium nitrate versus calcitonin

    Source sentences

    Summary
    Median duration of normocalcemia before other cytotoxic or hypocalcemic therapy was 6 days for patients treated with gallium nitrate compared with 1 day for patients treated with calcitonin (P less than 0.001).
    2 context sentences
    Summary · context
    Randomized, double-blind comparison of active treatments.
    Summary · context
    Gallium nitrate 200 mg/m2 body surface area for 5 days by continuous intravenous infusion, or salmon calcitonin 8 IU/kg body weight every 6 hours for 5 days by intramuscular injection.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In cancer-related hypercalcemia, median unadjusted normocalcemia lasted 2 days with calcitonin versus 11+ days with gallium nitrate (P less than 0.01).

    In plain wordsIn cancer-related hypercalcemia, normocalcemia regardless of intercurrent treatment lasted less time with calcitonin than with gallium nitrate.

    Peptide
    Calcitonin-salmon
    Outcome
    DecreaseNormocalcemia duration regardless of intercurrent treatment
    Study

    n: not reported in source

    Comparator
    Gallium nitrate
    Outcome group
    Electrolyte balance · Endocrine and hormones
    Studied dose
    8 IU/kg every 6 hours · intramuscular · 5 daysAs given in this study (human).

    Measurements

    Median normocalcemia duration
    2 days
    calcitonin
    Median normocalcemia duration
    ≥ 11 days
    gallium nitrate
    P value
    < 0.01
    gallium nitrate versus calcitonin

    Source sentences

    Summary
    Median duration of normocalcemia regardless of intercurrent treatment and without adjustment for serum albumin was 11+ days for patients treated with gallium nitrate and 2 days for patients treated with calcitonin (P less than 0.01).
    2 context sentences
    Summary · context
    Randomized, double-blind comparison of active treatments.
    Summary · context
    Gallium nitrate 200 mg/m2 body surface area for 5 days by continuous intravenous infusion, or salmon calcitonin 8 IU/kg body weight every 6 hours for 5 days by intramuscular injection.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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