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Study · In vitro (cells) · 1988

4 results

Production of human B and T cell growth factors is enhanced by thymic hormones.

Kouttab NM, Goldstein AL, Lu M, Lu L, Campbell B, Maizel AL

Immunopharmacology1 Sept 1988Cited by 16 (Europe PMC)

PMID3264553 (opens in a new tab)DOI10.1016/0162-3109(88)90018-5 (opens in a new tab)PepBankPUB-03264553
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In human peripheral blood mononuclear cells, synthetic thymosin alpha‑1 enhanced production of B cell growth factor (BCGF-12kD).

    In plain wordsIn cells, thymosin alpha‑1 raised the production of a B cell growth factor.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseB cell growth factor (BCGF-12kD) production
    Study

    humann: not reported in source

    Human peripheral blood mononuclear cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The results showed that both TF5 and T alpha 1 were capable of enhancing the production of a B cell growth factor (BCGF-12kD) and T cell growth factor (TCGF; IL-2).
    1 context sentence
    Summary · context
    The thymic preparations thymosin fraction 5 (TF5) and synthetic thymosin alpha 1 (T alpha 1) were examined for their ability to enhance growth factor production by human peripheral blood mononuclear cells (PBMC).
  2. 02LabIn vitro (cells)Activity measurement

    In human peripheral blood mononuclear cells, synthetic thymosin alpha‑1 enhanced production of T cell growth factor (IL-2).

    In plain wordsIn cells, thymosin alpha‑1 raised the production of the T cell growth factor IL-2.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseT cell growth factor (IL-2) production
    Study

    humann: not reported in source

    Human peripheral blood mononuclear cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The results showed that both TF5 and T alpha 1 were capable of enhancing the production of a B cell growth factor (BCGF-12kD) and T cell growth factor (TCGF; IL-2).
    1 context sentence
    Summary · context
    The thymic preparations thymosin fraction 5 (TF5) and synthetic thymosin alpha 1 (T alpha 1) were examined for their ability to enhance growth factor production by human peripheral blood mononuclear cells (PBMC).
  3. 03LabIn vitro (cells)Activity measurement

    In human peripheral blood mononuclear cells, thymosin alpha‑1 enhanced growth factor production at 100-200-fold lower concentrations than thymosin fraction 5.

    In plain wordsIn cells, thymosin alpha‑1 worked at much lower concentrations than the thymosin fraction 5 extract.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableConcentration needed for growth factor enhancement versus TF5
    Study

    humann: not reported in source

    Human peripheral blood mononuclear cells
    Comparator
    Thymosin fraction 5 (TF5)
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Measurements

    Concentration ratio
    100 to 200 -fold lower
    T alpha 1 versus TF5

    Source sentences

    Summary
    Enhancement by T alpha 1 could be obtained at 100-200-fold lower concentrations than that seen with TF5.
    1 context sentence
    Summary · context
    The thymic preparations thymosin fraction 5 (TF5) and synthetic thymosin alpha 1 (T alpha 1) were examined for their ability to enhance growth factor production by human peripheral blood mononuclear cells (PBMC).

Studies that did not test the peptide alone1

In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin alpha-1.

  1. 04LabNot a test of Thymosin alpha-1 aloneIn vitro (cells)Activity measurement

    Thymic hormones (TF5 and thymosin alpha‑1 together) had no direct effect on test B and T cells.

    In plain wordsIn cells, the thymic hormone preparations had no direct effect on the test B and T cells.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeDirect effect of thymic hormones on test B and T cells
    Study

    humann: not reported in source

    Human peripheral blood mononuclear cells
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Furthermore, no direct effect of thymic hormones on test B and T cells was observed.
    1 context sentence
    Summary · context
    The thymic preparations thymosin fraction 5 (TF5) and synthetic thymosin alpha 1 (T alpha 1) were examined for their ability to enhance growth factor production by human peripheral blood mononuclear cells (PBMC).

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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