Immunocytochemical analysis of calcitonin gene-related peptide and vasoactive intestinal polypeptide in Merkel cells and cutaneous free nerve endings of cats.

Alvarez FJ, Cervantes C, Villalba R, Blasco I, Martínez-Murillo R, Polak JM, Rodrigo J

Cell and tissue research1 Nov 1988Cited by 34 (Europe PMC)

PMID3264208DOI10.1007/bf00225816PepBankPUB-03264208

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Other
In cats, CGRP and VIP immunoreactivity coexisted in Merkel cells.
In plain wordsIn cats, skin touch-sensing Merkel cells held the body's own VIP together with CGRP.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableCoexistence of CGRP and VIP immunoreactivity in Merkel cells
Study
catn: not reported in source
Merkel cells and cutaneous nerve endings
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
Calcitonin gene-related peptide (CGRP)- and vasoactive intestinal polypeptide (VIP)-immunoreactivity were observed to coexist in Merkel cells of cats.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0326420801
02AnimalEndogenous levelAnimal study (in vivo)Other
In cats, no differences in peptide content were found between Merkel cells of the hard palate epithelium, hairy and glabrous upper lip skin, and vibrissae follicles.
In plain wordsIn cats, no difference was found in the content of the body's own VIP and CGRP in Merkel cells at different body sites.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changePeptide content of Merkel cells by location
Study
catn: not reported in source
Merkel cells and cutaneous nerve endings
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
No differences in peptide content were found between Merkel cells located in epithelia of the hard palate, in hairy and glabrous skin of the upper lip, and in vibrissae follicles.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0326420802
03AnimalEndogenous levelAnimal study (in vivo)Other
In cats, CGRP- and VIP-immunoreactive nerve fibres were found near CGRP/VIP-immunoreactive Merkel cells.
In plain wordsIn cats, nerve fibres holding the body's own VIP lay near Merkel cells that also held it.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableVIP-immunoreactive nerve fibres near Merkel cells
Study
catn: not reported in source
Merkel cells and cutaneous nerve endings
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
CGRP- and VIP-immunoreactive nerve fibres were also found near CGRP/VIP-immunoreactive Merkel cells.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0326420803
04AnimalEndogenous levelAnimal study (in vivo)Other
In cat vibrissae follicles, some CGRP- and VIP-immunoreactive nerve terminals ended abutting on the glassy membrane.
In plain wordsIn cat whisker follicles, some nerve endings holding the body's own VIP ended against the glassy membrane.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableVIP-immunoreactive nerve terminals in vibrissae follicles
Study
catn: not reported in source
Merkel cells and cutaneous nerve endings
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
In the vibrissae follicles some CGRP- and VIP-immunoreactive nerve terminals end abutting on the glassy membrane.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0326420804
05AnimalEndogenous levelAnimal study (in vivo)Other
In cat skin, CGRP- and VIP-immunoreactive nerve fibres end as free nerve endings and not as Merkel cell neurites.
In plain wordsIn cats, nerve fibres holding the body's own VIP ended freely in skin, not as part of Merkel cells.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableType of VIP-immunoreactive nerve endings in skin
Study
catn: not reported in source
Merkel cells and cutaneous nerve endings
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
Electron microscopy of vibrissae follicles revealed that Merkel cell neurites are not immunostained and that immunostained nerve fibres form unmyelinated bundles before ending freely. Thus, CGRP- and VIP-immunoreactive nerve fibres in cat skin do not end as Merkel cell neurites but as different kind…
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0326420805

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

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