The release of luteinizing hormone from pituitaries perifused with thymic extracts.

Zaidi SA, Kendall MD, Gillham B, Jones MT

Thymus1 Jan 1988Cited by 19 (Europe PMC)

PMID3256093PepBankPUB-03256093

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

2 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueEfficacy outcome
In pituitary tissue in vitro, thymosin alpha‑1 did not cause release of luteinizing hormone, unlike facteur thymique serique.
In plain wordsIn lab tests on pituitary tissue, thymosin alpha‑1 did not cause release of luteinizing hormone, unlike another thymic peptide.
Peptide
Thymosin alpha-1
Outcome
No significant changeRelease of luteinizing hormone from pituitary tissue
Study
n: not reported in source
Pituitary tissue in vitro
Comparator
FTS (caused dose-related LH release)
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
In separate experiments in vitro FTS, but not two other thymic peptides, thymopoietin and thymosin alpha 1, caused a dose-related release of LH from pituitary tissue.
Report a problemFND-0325609301
02LabEx vivo tissueActivity measurement
In pituitary tissue in vitro, FTS caused dose-related LH release.
In plain wordsIn lab tests, thymulin caused dose-related release of luteinizing hormone from pituitary tissue.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseLH release
Study
ratn: not reported in source
Rat thymus and anterior pituitary tissue
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
In separate experiments in vitro FTS, but not two other thymic peptides, thymopoietin and thymosin alpha 1, caused a dose-related release of LH from pituitary tissue.
Report a problemFND-0325609303

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

03LabEndogenous levelEx vivo tissueOther
In rat thymus perifusates, endogenous FTS levels were highest in potassium-stimulated fractions with the greatest LH-releasing activity.
In plain wordsIn lab tests, natural thymulin levels were highest in rat thymus fractions with the greatest LH-releasing activity.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseFTS levels in LH-releasing fractions
Study
ratn: not reported in source
Rat thymus and anterior pituitary tissue
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Levels of facteur thymique serique (FTS), as measured by bioassay are highest in K+ stimulated fractions that exhibit the greatest LH releasing activity.
1 context sentence(design, population, supporting numbers)
Summary · context
Medium obtained by the perifusion of fragments of adult male CSE rat thymuses stimulates the release of luteinizing hormone (LH) from the anterior pituitary gland in vitro.
This result measures the body's own Thymulin (serum thymic factor). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0325609302

Studies that did not test the peptide alone4

In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymulin (serum thymic factor).

04LabNot a test of Thymulin (serum thymic factor) aloneEx vivo tissueActivity measurement
In lab tests, adult rat thymus perifusates containing FTS stimulated LH release from anterior pituitary tissue.
In plain wordsIn lab tests, adult rat thymus fluid containing thymulin stimulated luteinizing hormone release from pituitary tissue.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseLH release with adult thymus perifusates
Study
ratn: not reported in source
Rat thymus perifusates and anterior pituitary tissue
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Medium obtained by the perifusion of fragments of adult male CSE rat thymuses stimulates the release of luteinizing hormone (LH) from the anterior pituitary gland in vitro.
1 context sentence(design, population, supporting numbers)
Summary · context
Levels of facteur thymique serique (FTS), as measured by bioassay are highest in K+ stimulated fractions that exhibit the greatest LH releasing activity.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-0325609304
05LabNot a test of Thymulin (serum thymic factor) aloneEx vivo tissueActivity measurement
In lab tests, neonatal rat thymus perifusates produced no significant effect on pituitary LH release.
In plain wordsIn lab tests, neonatal rat thymus fluid produced no significant effect on luteinizing hormone release from pituitary tissue.
Peptide
Thymulin (serum thymic factor)
Outcome
No significant changeLH release with neonatal thymus perifusates
Study
ratn: not reported in source
Rat thymus perifusates and anterior pituitary tissue
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
That ability of thymic perifusates to cause the release of LH was age-related because tissue from neonatal and ageing males failed to release compounds with any significant effect on the pituitary release of LH.
1 context sentence(design, population, supporting numbers)
Summary · context
Levels of facteur thymique serique (FTS), as measured by bioassay are highest in K+ stimulated fractions that exhibit the greatest LH releasing activity.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-0325609305
06LabNot a test of Thymulin (serum thymic factor) aloneEx vivo tissueActivity measurement
In lab tests, ageing male rat thymus perifusates produced no significant effect on pituitary LH release.
In plain wordsIn lab tests, ageing male rat thymus fluid produced no significant effect on luteinizing hormone release from pituitary tissue.
Peptide
Thymulin (serum thymic factor)
Outcome
No significant changeLH release with ageing thymus perifusates
Study
ratn: not reported in source
Rat thymus perifusates and anterior pituitary tissue
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
That ability of thymic perifusates to cause the release of LH was age-related because tissue from neonatal and ageing males failed to release compounds with any significant effect on the pituitary release of LH.
1 context sentence(design, population, supporting numbers)
Summary · context
Levels of facteur thymique serique (FTS), as measured by bioassay are highest in K+ stimulated fractions that exhibit the greatest LH releasing activity.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-0325609306
07LabNot a test of Thymulin (serum thymic factor) aloneEx vivo tissueActivity measurement
In lab tests, thymus perifusates from ageing rats after orchidectomy elicited LH release similar to that with young adult male tissue.
In plain wordsIn lab tests, thymus fluid from ageing rats after testicle removal stimulated luteinizing hormone release similarly to young adult male tissue.
Peptide
Thymulin (serum thymic factor)
Outcome
No significant changeLH release with thymus perifusates after orchidectomy
Study
ratn: not reported in source
Rat thymus perifusates and anterior pituitary tissue
Comparator
Young adult male rat thymus tissue
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
However, when the thymus was enlarged in ageing rats as a result of orchidectomy 1 month before sacrifice LH release was similar to that observed in young male adults.
2 context sentences(design, population, supporting numbers)
Summary · context
Medium obtained by the perifusion of fragments of adult male CSE rat thymuses stimulates the release of luteinizing hormone (LH) from the anterior pituitary gland in vitro.
Summary · context
Levels of facteur thymique serique (FTS), as measured by bioassay are highest in K+ stimulated fractions that exhibit the greatest LH releasing activity.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-0325609307

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Versions 5 to 13Current
28 Oct 2026, 02:02 UTC
The same notice was added 9 times, first on 21 Oct 2026, 15:59 UTC. The status did not change between them.
Study results updated
Version 4
21 Oct 2026, 12:50 UTC
Study data updated · source update from Europe PMC
Version 3
10 Oct 2026, 08:55 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 03:02 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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