Neurohypophyseal aging: differential changes in oxytocin and vasopressin release, studied in Fischer 344 and Sprague-Dawley rats.

Zbuzek V, Fuchs AR, Zbuzek VK, Wu WH

Neuroendocrinology1 Dec 1988Cited by 14 (Europe PMC)

PMID3251161DOI10.1159/000125072PepBankPUB-03251161

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Mechanism
In aged (26 months) male F344 rats, plasma oxytocin concentration was unaltered compared with young rats.
In plain wordsIn old rats, the body's own oxytocin in the blood was not different from young rats.
Peptide
Oxytocin
Outcome
No significant changePlasma oxytocin concentration in aged rats
Study
Ratn: not reported in source
Aged (26 months) male Fischer 344 rats
Comparator
Young rats (2-3 months)
Outcome group
Aging markers · Aging and longevity
Source sentences
Summary
using aged (26 months) male Fischer 344 (F344) rats, we showed that in contrast to vasopressin, oxytocin plasma concentration and hypothalamic content were unaltered in comparison with young (2-3 months) rats; however, based on data from our past and current studies, the neurohypophyseal concentrati…
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0325116101
02AnimalEndogenous levelAnimal study (in vivo)Mechanism
In aged (26 months) male F344 rats, hypothalamic oxytocin content was unaltered compared with young rats.
In plain wordsIn old rats, the body's own oxytocin in the hypothalamus was not different from young rats.
Peptide
Oxytocin
Outcome
No significant changeHypothalamic oxytocin content in aged rats
Study
Ratn: not reported in source
Aged (26 months) male Fischer 344 rats
Comparator
Young rats (2-3 months)
Outcome group
Aging markers · Aging and longevity
Source sentences
Summary
using aged (26 months) male Fischer 344 (F344) rats, we showed that in contrast to vasopressin, oxytocin plasma concentration and hypothalamic content were unaltered in comparison with young (2-3 months) rats; however, based on data from our past and current studies, the neurohypophyseal concentrati…
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0325116102
03AnimalEndogenous levelAnimal study (in vivo)Mechanism
In aged rats, the neurohypophyseal concentration of oxytocin was decreased compared with young rats.
In plain wordsIn old rats, the body's own oxytocin in the back of the pituitary was lower than in young rats.
Peptide
Oxytocin
Outcome
DecreaseNeurohypophyseal oxytocin concentration in aged rats
Study
Ratn: not reported in source
Aged (26 months) male Fischer 344 rats
Comparator
Young rats (2-3 months)
Outcome group
Aging markers · Aging and longevity
Source sentences
Summary
based on data from our past and current studies, the neurohypophyseal concentrations of both hormones were found to be decreased in aged rats.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0325116103
04LabEndogenous levelEx vivo tissueMechanism
In isolated neural lobes, basal oxytocin release per gland was increased in aged rats of both strains.
In plain wordsIn lab tests of rat pituitary tissue, old rats released more of the body's own oxytocin at rest than young rats.
Peptide
Oxytocin
Outcome
IncreaseBasal oxytocin release per gland in aged rats
Study
Ratn: not reported in source
Isolated neural lobes, superfusion
Comparator
Young rats (2-3 months)
Outcome group
Aging markers · Aging and longevity
Source sentences
Summary
Expressed per gland, basal release of oxytocin increased in aged rats of both strains
1 context sentence(design, population, supporting numbers)
Summary · context
Superfusion technique was employed to examine oxytocin and vasopressin release from isolated neural lobes of young (2-3 months) and old (26 months) male F344 and young (2-3 months), middle-aged (12 months) and old (30 months) Sprague-Dawley (SD) rats.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0325116104
05LabEndogenous levelEx vivo tissueMechanism
In isolated neural lobes, oxytocin responses to electrical stimulation, 56 mM K+ and initial traumatic release were either unaltered or decreased much less in aged rats than vasopressin responses.
In plain wordsIn lab tests of rat pituitary tissue, old rats' release of the body's own oxytocin on stimulation was little changed, unlike vasopressin release.
Peptide
Oxytocin
Outcome
MixedOxytocin release responses to stimulation in aged rats
Study
Ratn: not reported in source
Isolated neural lobes, superfusion
Comparator
Young rats (2-3 months)
Outcome group
Aging markers · Aging and longevity
Source sentences
Summary
The vasopressin responses to electrical stimulation, 56 mM K+ and initial traumatic release were decreased in aged rats; whereas oxytocin responses were either unaltered or decreased much less.
1 context sentence(design, population, supporting numbers)
Summary · context
Superfusion technique was employed to examine oxytocin and vasopressin release from isolated neural lobes of young (2-3 months) and old (26 months) male F344 and young (2-3 months), middle-aged (12 months) and old (30 months) Sprague-Dawley (SD) rats.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0325116105

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Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:52 UTC
First added · source update from Europe PMC

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