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Study · Animal study (in vivo) · rat · 1988

5 results

Effect of bombesin, dermorphin and salmon calcitonin on gastric acid secretion in rats.

Guglietta A, Irons BJ, Lazarus LH

Methods and findings in experimental and clinical pharmacology1 Aug 1988Cited by 4 (Europe PMC)

PMID3226218 (opens in a new tab)PepBankPUB-03226218
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, central dermorphin administration significantly reduced gastric acid output.

    In plain wordsIn rats, central dermorphin administration significantly reduced gastric acid output.

    Peptide
    Dermorphin
    Outcome
    DecreaseGastric acid output after central administration
    Study

    ratn: not reported in source

    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated · intracerebroventricular · two hoursAs given in this study (rat).

    Source sentences

    Summary
    All three peptides significantly reduced gastric acid output after central administration.
    1 context sentence
    Summary · context
    A comparison of the effect of bombesin, dermorphin and salmon calcitonin on gastric acid secretion was assayed in rats two hours after their intracerebroventricular or subcutaneous administration.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, dermorphin was less potent than bombesin at inhibiting gastric acid output after central administration.

    In plain wordsIn rats, central dermorphin was less potent than bombesin at inhibiting gastric acid output.

    Peptide
    Dermorphin
    Outcome
    DecreaseGastric acid inhibition potency versus bombesin
    Study

    ratn: not reported in source

    Comparator
    Bombesin
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    The order of potency was: bombesin greater than salmon calcitonin greater than dermorphin.
    2 context sentences
    Summary · context
    All three peptides significantly reduced gastric acid output after central administration.
    Summary · context
    A comparison of the effect of bombesin, dermorphin and salmon calcitonin on gastric acid secretion was assayed in rats two hours after their intracerebroventricular or subcutaneous administration.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, dermorphin was less potent than salmon calcitonin at inhibiting gastric acid output after central administration.

    In plain wordsIn rats, central dermorphin was less potent than salmon calcitonin at inhibiting gastric acid output.

    Peptide
    Dermorphin
    Outcome
    DecreaseGastric acid inhibition potency versus salmon calcitonin
    Study

    ratn: not reported in source

    Comparator
    Salmon calcitonin
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    The order of potency was: bombesin greater than salmon calcitonin greater than dermorphin.
    2 context sentences
    Summary · context
    All three peptides significantly reduced gastric acid output after central administration.
    Summary · context
    A comparison of the effect of bombesin, dermorphin and salmon calcitonin on gastric acid secretion was assayed in rats two hours after their intracerebroventricular or subcutaneous administration.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats, subcutaneous dermorphin reduced gastric acid output only at high doses.

    In plain wordsIn rats, subcutaneous dermorphin reduced gastric acid output only at high doses.

    Peptide
    Dermorphin
    Outcome
    DecreaseGastric acid output after subcutaneous administration
    Study

    ratn: not reported in source

    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated · subcutaneous · two hoursAs given in this study (rat).

    Source sentences

    Summary
    After subcutaneous injection salmon calcitonin was very potent in reducing gastric acid output, while dermorphin was active only at high doses; bombesin had a very weak effect on the same parameter.
    1 context sentence
    Summary · context
    A comparison of the effect of bombesin, dermorphin and salmon calcitonin on gastric acid secretion was assayed in rats two hours after their intracerebroventricular or subcutaneous administration.
  5. 05AnimalAnimal study (in vivo)Activity measurement

    In rats, dermorphin's central effect peaked 1-2 h after administration, followed by slow recovery toward control values.

    In plain wordsIn rats, dermorphin's central effect peaked after administration, followed by slow recovery toward control values.

    Peptide
    Dermorphin
    Outcome
    Not applicableTime course of central gastric acid inhibition
    Study

    ratn: not reported in source

    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Measurements

    Time to peak effect
    1 to 2 h
    After central administration

    Source sentences

    Summary
    Time-course studies demonstrated that the effect of these peptides reached a peak 1-2 h after their central administration, followed by a slow recovery toward control values.
    1 context sentence
    Summary · context
    A comparison of the effect of bombesin, dermorphin and salmon calcitonin on gastric acid secretion was assayed in rats two hours after their intracerebroventricular or subcutaneous administration.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 2

    27 Oct 2026, 16:35 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

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