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Study · Animal study (in vivo) · rat · 1988

4 results

Effect of human parathyroid hormone (PTH(1-34)) on experimental osteopenia of rats induced by ovariectomy.

Hori M, Uzawa T, Morita K, Noda T, Takahashi H, Inoue J

Bone and mineral1 Jan 1988Cited by 56 (Europe PMC)

PMID3207944 (opens in a new tab)PepBankPUB-03207944
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, PTH dose-dependently prevented the reduction in bone dry weight.

    In plain wordsIn ovariectomized rats, PTH prevented bone dry weight loss compared with untreated ovariectomized rats.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseBone dry weight
    Study

    ratn: not reported in source

    ovariectomized immature female Sprague-Dawley rats
    Comparator
    ovariectomized rats without PTH
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    1.5-6.0 micrograms/kg three times a week · subcutaneous · 25 weeksAs given in this study (rat).

    Source sentences

    Summary
    Human PTH(1-34) prevented the reduction of dry weight, ash weight, calcium content and phosphorus content dose dependently (1.5-6.0 micrograms/kg) in ovariectomized rats.
    2 context sentences
    Summary · context
    The effect of human PTH(1-34) on the development of osteopenia induced by ovariectomy was investigated in immature female Sprague-Dawley rats.
    Summary · context
    After the surgery, human PTH(1-34) was injected subcutaneously three times a week for 25 weeks.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, PTH dose-dependently prevented the reduction in bone ash weight.

    In plain wordsIn ovariectomized rats, PTH prevented bone ash weight loss compared with untreated ovariectomized rats.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseBone ash weight
    Study

    ratn: not reported in source

    ovariectomized immature female Sprague-Dawley rats
    Comparator
    ovariectomized rats without PTH
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    1.5-6.0 micrograms/kg three times a week · subcutaneous · 25 weeksAs given in this study (rat).

    Source sentences

    Summary
    Human PTH(1-34) prevented the reduction of dry weight, ash weight, calcium content and phosphorus content dose dependently (1.5-6.0 micrograms/kg) in ovariectomized rats.
    2 context sentences
    Summary · context
    The effect of human PTH(1-34) on the development of osteopenia induced by ovariectomy was investigated in immature female Sprague-Dawley rats.
    Summary · context
    After the surgery, human PTH(1-34) was injected subcutaneously three times a week for 25 weeks.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, PTH dose-dependently prevented the reduction in bone calcium content.

    In plain wordsIn ovariectomized rats, PTH prevented bone calcium loss compared with untreated ovariectomized rats.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseBone calcium content
    Study

    ratn: not reported in source

    ovariectomized immature female Sprague-Dawley rats
    Comparator
    ovariectomized rats without PTH
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    1.5-6.0 micrograms/kg three times a week · subcutaneous · 25 weeksAs given in this study (rat).

    Source sentences

    Summary
    Human PTH(1-34) prevented the reduction of dry weight, ash weight, calcium content and phosphorus content dose dependently (1.5-6.0 micrograms/kg) in ovariectomized rats.
    2 context sentences
    Summary · context
    The effect of human PTH(1-34) on the development of osteopenia induced by ovariectomy was investigated in immature female Sprague-Dawley rats.
    Summary · context
    After the surgery, human PTH(1-34) was injected subcutaneously three times a week for 25 weeks.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, PTH dose-dependently prevented the reduction in bone phosphorus content.

    In plain wordsIn ovariectomized rats, PTH prevented bone phosphorus loss compared with untreated ovariectomized rats.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseBone phosphorus content
    Study

    ratn: not reported in source

    ovariectomized immature female Sprague-Dawley rats
    Comparator
    ovariectomized rats without PTH
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    1.5-6.0 micrograms/kg three times a week · subcutaneous · 25 weeksAs given in this study (rat).

    Source sentences

    Summary
    Human PTH(1-34) prevented the reduction of dry weight, ash weight, calcium content and phosphorus content dose dependently (1.5-6.0 micrograms/kg) in ovariectomized rats.
    2 context sentences
    Summary · context
    The effect of human PTH(1-34) on the development of osteopenia induced by ovariectomy was investigated in immature female Sprague-Dawley rats.
    Summary · context
    After the surgery, human PTH(1-34) was injected subcutaneously three times a week for 25 weeks.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

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