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Study · Measured the body's own peptide · 1988

3 results

Spinal cord lesions at different levels affect either the adrenergic or vasoactive intestinal polypeptide-immunoreactive nerves in the human urethra.

Crowe R, Burnstock G, Light JK

The Journal of urology1 Dec 1988Cited by 6 (Europe PMC)

PMID3193505 (opens in a new tab)DOI10.1016/s0022-5347(17)42058-1 (opens in a new tab)PepBankPUB-03193505
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelCase report or seriesOther

    In patients with cervical or thoracic spinal cord lesions, no VIP-immunoreactive nerves were found around striated muscle fibres of the intrinsic external urethral sphincter.

    In plain wordsIn three patients with spinal cord lesions, no nerves holding the body's own VIP were found around the striated muscle of the urethral sphincter.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    No significant changeVIP-immunoreactive nerves around striated muscle of external urethral sphincter
    Study

    n = 3

    Urethral tissue from patients with spinal cord lesions
    Outcome group
    Endogenous peptide levels · Kidney and urinary

    Source sentences

    Summary
    In patients with cervical or thoracic lesions neither adrenergic nor vasoactive intestinal polypeptide-immunoreactive nerves were found around striated muscle fibers of the intrinsic external urethral sphincter.
    1 context sentence
    Summary · context
    The urethras from 1 patient with cervical (C1-2) and 2 patients with thoracic (T10) spinal cord lesions were studied histochemically and immunohistochemically for adrenergic and vasoactive intestinal polypeptide-immunoreactive nerves.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelCase report or seriesOther

    In two patients with thoracic (T10) spinal cord lesions, dense VIP-immunoreactive but not adrenergic nerves were found in urethral smooth muscle, around blood vessels and at the base of the mucosa.

    In plain wordsIn two patients with a thoracic spinal cord lesion, the urethra had many nerves holding the body's own VIP.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableVIP-immunoreactive nerves in urethra of patients with thoracic lesions
    Study

    n = 2

    Urethral tissue from patients with spinal cord lesions
    Outcome group
    Endogenous peptide levels · Kidney and urinary

    Source sentences

    Summary
    Dense vasoactive intestinal polypeptide-immunoreactive but not adrenergic nerves were found in the urethral smooth muscle, around the blood vessels and at the base of the mucosa in the patients with thoracic lesions.
    1 context sentence
    Summary · context
    The urethras from 1 patient with cervical (C1-2) and 2 patients with thoracic (T10) spinal cord lesions were studied histochemically and immunohistochemically for adrenergic and vasoactive intestinal polypeptide-immunoreactive nerves.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelCase report or seriesOther

    In one patient with a cervical (C1-2) spinal cord lesion, adrenergic but not VIP-immunoreactive nerves were found with urethral smooth muscle and around blood vessels.

    In plain wordsIn one patient with a neck-level spinal cord lesion, the urethra had adrenergic nerves but none holding the body's own VIP.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableVIP-immunoreactive nerves in urethra of patient with cervical lesion
    Study

    n = 1

    Urethral tissue from patients with spinal cord lesions
    Outcome group
    Endogenous peptide levels · Kidney and urinary

    Source sentences

    Summary
    In contrast, adrenergic but not vasoactive intestinal polypeptide-immunoreactive nerves were found associated with the smooth muscle of the urethra and around the blood vessels in the patient with a cervical lesion.
    1 context sentence
    Summary · context
    The urethras from 1 patient with cervical (C1-2) and 2 patients with thoracic (T10) spinal cord lesions were studied histochemically and immunohistochemically for adrenergic and vasoactive intestinal polypeptide-immunoreactive nerves.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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