Skip to content

Study · Animal study (in vivo) · rat · 1988

4 results

Sleep-promoting effect following intracerebroventricular injection of a phosphorylated analogue of delta sleep-inducing peptide (DSIP-P) in rats.

Nakagaki K, Ebihara S, Usui S, Honda Y, Takahashi Y

Neuroscience letters1 Aug 1988Cited by 3 (Europe PMC)

PMID3185958 (opens in a new tab)DOI10.1016/0304-3940(88)90761-6 (opens in a new tab)PepBankPUB-03185958
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, intracerebroventricular DSIP-P (200 pmol/kg) increased slow-wave sleep by 17.3% in the dark period after injection.

    In plain wordsIn rats, a phosphorylated form of DSIP given into the brain increased deep slow-wave sleep during the dark period.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseSlow-wave sleep in the dark period
    Study

    ratn: not reported in source

    Male rats, 12:12 h light-dark cycle
    Outcome group
    Sleep · Sleep
    Studied dose
    200 pmol/kg · intracerebroventricularAs given in this study (rat).

    Measurements

    SWS increase
    17.3%
    200 pmol/kg

    Source sentences

    Summary
    DSIP-P resulted in increases of slow-wave sleep (SWS) (17.3%, P less than 0.01) and paradoxical sleep (PS) (32.3%, P less than 0.05) during the subsequent dark period without shortening sleep latency in the dose of 200 pmol/kg.
    1 context sentence
    Summary · context
    DSIP-P (20 or 200 pmol/kg) was injected into the third cerebroventricle of male rats immediately before the onset of the dark period of a 12:12 h light-dark cycle.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, intracerebroventricular DSIP-P (200 pmol/kg) increased paradoxical sleep by 32.3% in the dark period after injection.

    In plain wordsIn rats, a phosphorylated form of DSIP given into the brain increased paradoxical (REM-like) sleep during the dark period.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseParadoxical sleep in the dark period
    Study

    ratn: not reported in source

    Male rats, 12:12 h light-dark cycle
    Outcome group
    Sleep · Sleep
    Studied dose
    200 pmol/kg · intracerebroventricularAs given in this study (rat).

    Measurements

    PS increase
    32.3%
    200 pmol/kg

    Source sentences

    Summary
    DSIP-P resulted in increases of slow-wave sleep (SWS) (17.3%, P less than 0.01) and paradoxical sleep (PS) (32.3%, P less than 0.05) during the subsequent dark period without shortening sleep latency in the dose of 200 pmol/kg.
    1 context sentence
    Summary · context
    DSIP-P (20 or 200 pmol/kg) was injected into the third cerebroventricle of male rats immediately before the onset of the dark period of a 12:12 h light-dark cycle.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, DSIP-P (200 pmol/kg) did not shorten sleep latency.

    In plain wordsIn rats, a phosphorylated form of DSIP did not make sleep start sooner.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeSleep latency
    Study

    ratn: not reported in source

    Male rats, 12:12 h light-dark cycle
    Outcome group
    Sleep · Sleep
    Studied dose
    200 pmol/kg · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    DSIP-P resulted in increases of slow-wave sleep (SWS) (17.3%, P less than 0.01) and paradoxical sleep (PS) (32.3%, P less than 0.05) during the subsequent dark period without shortening sleep latency in the dose of 200 pmol/kg.
    1 context sentence
    Summary · context
    DSIP-P (20 or 200 pmol/kg) was injected into the third cerebroventricle of male rats immediately before the onset of the dark period of a 12:12 h light-dark cycle.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, the slow-wave sleep increase after DSIP-P carried over to the next light period and returned to control levels on the second day.

    In plain wordsIn rats, the extra deep sleep after a phosphorylated form of DSIP lasted into the next light period and was gone by the second day.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseSlow-wave sleep in the next light period
    Study

    ratn: not reported in source

    Male rats, 12:12 h light-dark cycle
    Outcome group
    Sleep · Sleep
    Studied dose
    200 pmol/kg · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    The SWS-promoting effect was carried over to the next light period. These changes returned to control levels on the second day.
    1 context sentence
    Summary · context
    DSIP-P (20 or 200 pmol/kg) was injected into the third cerebroventricle of male rats immediately before the onset of the dark period of a 12:12 h light-dark cycle.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.