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Study · In vitro (cells) · 1988

2 results

Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+.

Maquart FX, Pickart L, Laurent M, Gillery P, Monboisse JC, Borel JP

FEBS letters1 Oct 1988Cited by 118 (Europe PMC)

PMID3169264 (opens in a new tab)DOI10.1016/0014-5793(88)80509-x (opens in a new tab)PepBankPUB-03169264
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In fibroblast cultures, GHK‑Cu stimulated collagen synthesis, starting between 10(-12) and 10(-11) M and maximal at 10(-9) M.

    In plain wordsIn cells, GHK‑Cu raised collagen production by fibroblasts, with the largest effect at one concentration.

    Peptide
    GHK-Cu
    Outcome
    IncreaseCollagen synthesis by fibroblasts
    Study

    n: not reported in source

    Fibroblast cultures
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We report the stimulating effect of GHK-Cu on collagen synthesis by fibroblasts. The stimulation began between 10(-12) and 10(-11) M, maximized at 10(-9) M, and was independent of any change in cell number.
    1 context sentence
    Summary · context
    This peptide appears to play a physiological role in wound healing.
  2. 02LabIn vitro (cells)Efficacy outcome

    In fibroblast cultures, the stimulation of collagen synthesis by GHK‑Cu was independent of any change in cell number.

    In plain wordsIn cells, the rise in collagen production with GHK‑Cu did not depend on a change in the number of cells.

    Peptide
    GHK-Cu
    Outcome
    No significant changeFibroblast cell number
    Study

    n: not reported in source

    Fibroblast cultures
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    and was independent of any change in cell number.
    2 context sentences
    Summary · context
    We report the stimulating effect of GHK-Cu on collagen synthesis by fibroblasts.
    Summary · context
    This peptide appears to play a physiological role in wound healing.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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