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Study · Randomized controlled trial · 1988

5 results

Vasopressin but not oxytocin enhances cortical arousal: an integrative hypothesis on behavioral effects of neurohypophyseal hormones.

Fehm-Wolfsdorf G, Bachholz G, Born J, Voigt K, Fehm HL

Psychopharmacology1 Jan 1988Cited by 43 (Europe PMC)

PMID3131794 (opens in a new tab)DOI10.1007/bf00212844 (opens in a new tab)PepBankPUB-03131794
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In male volunteers, intranasal oxytocin did not change learning of a 25-word list, in a comparison with placebo and vasopressin.

    In plain wordsIn men, nasal oxytocin did not change word learning compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeVerbal learning of a 25-noun list
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (Human).

    Source sentences

    Summary
    Neither learning nor long-term recall were affected by peptide treatments.
    2 context sentences
    Summary · context
    At the beginning of the session subjects had to learn a list of 25 unrelated nouns within five trials.
    Summary · context
    In a double-blind between-subject comparison with male volunteers receiving arginine-vasopressin (AVP), oxytocin or placebo intranasally prior to the experimental session, we tried to develop an alternative hypothesis on the basis of behavioral and EEG measures.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In male volunteers, intranasal oxytocin did not change recall of the word list 1 h later, in a comparison with placebo and vasopressin.

    In plain wordsIn men, nasal oxytocin did not change word recall one hour later compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeLong-term recall of the word list at 1 h
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (Human).

    Source sentences

    Summary
    Neither learning nor long-term recall were affected by peptide treatments.
    2 context sentences
    Summary · context
    Recall was assessed 1 h later.
    Summary · context
    In a double-blind between-subject comparison with male volunteers receiving arginine-vasopressin (AVP), oxytocin or placebo intranasally prior to the experimental session, we tried to develop an alternative hypothesis on the basis of behavioral and EEG measures.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In male volunteers, intranasal oxytocin did not enhance stimulus-related cortical arousal; only vasopressin raised vertex potential amplitude versus the other groups.

    In plain wordsIn men, nasal oxytocin did not raise brain arousal signals, unlike vasopressin, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeVertex auditory evoked potential amplitude (cortical arousal)
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (Human).

    Source sentences

    Summary
    Vasopressin-treated subjects, however, displayed significantly higher amplitudes of the vertex potential as compared to the other treatment groups.
    2 context sentences
    Summary · context
    Results indicate that vasopressin induces an enhancement of stimulus-related phasic cortical arousal, and that in this respect oxytocin has no effect.
    Summary · context
    In a double-blind between-subject comparison with male volunteers receiving arginine-vasopressin (AVP), oxytocin or placebo intranasally prior to the experimental session, we tried to develop an alternative hypothesis on the basis of behavioral and EEG measures.
  4. 04HumanRandomized controlled trialSafety outcome

    In male volunteers, no influence of the peptide treatments, oxytocin included, on heart rate was found.

    In plain wordsIn men, nasal oxytocin did not change heart rate compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeHeart rate
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · intranasalAs given in this study (Human).

    Source sentences

    Summary
    No influences on heart rate or blood pressure were found.
    1 context sentence
    Summary · context
    In a double-blind between-subject comparison with male volunteers receiving arginine-vasopressin (AVP), oxytocin or placebo intranasally prior to the experimental session, we tried to develop an alternative hypothesis on the basis of behavioral and EEG measures.
  5. 05HumanRandomized controlled trialSafety outcome

    In male volunteers, no influence of the peptide treatments, oxytocin included, on blood pressure was found.

    In plain wordsIn men, nasal oxytocin did not change blood pressure compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeBlood pressure
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Dose not stated · intranasalAs given in this study (Human).

    Source sentences

    Summary
    No influences on heart rate or blood pressure were found.
    1 context sentence
    Summary · context
    In a double-blind between-subject comparison with male volunteers receiving arginine-vasopressin (AVP), oxytocin or placebo intranasally prior to the experimental session, we tried to develop an alternative hypothesis on the basis of behavioral and EEG measures.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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